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Your search keyword '"LeBrasseur, Nathan K."' showing total 6 results
Start Over Author "LeBrasseur, Nathan K." Publisher american diabetes association
6 results on '"LeBrasseur, Nathan K."'

1. Erratum. TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle. Diabetes 2019;68:1552–1564

Author

Koh, Jin-Ho, primary, Johnson, Matthew L., additional, Dasari, Surendra, additional, LeBrasseur, Nathan K., additional, Vuckovic, Ivan, additional, Henderson, Gregory C., additional, Cooper, Shawna A., additional, Manjunatha, Shankarappa, additional, Ruegsegger, Gregory N., additional, Shulman, Gerald I., additional, Lanza, Ian R., additional, and Nair, K. Sreekumaran, additional

Published
2020
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2. TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle

Author

Koh, Jin-Ho, primary, Johnson, Matthew L., additional, Dasari, Surendra, additional, LeBrasseur, Nathan K., additional, Vuckovic, Ivan, additional, Henderson, Gregory C., additional, Cooper, Shawna A., additional, Manjunatha, Shankarappa, additional, Ruegsegger, Gregory N., additional, Shulman, Gerald I., additional, Lanza, Ian R., additional, and Nair, K. Sreekumaran, additional

Published
2019
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3. Why might thiazolidinediones increase exercise capacity in patients with type 2 diabetes?

Author

LeBrasseur, Nathan K. and Ruderman, Neil B.

Subjects
Women -- Health aspects, Exercise -- Health aspects, Thiazolidinediones -- Health aspects, Type 2 diabetes -- Drug therapy, Health, Drug therapy, Health aspects
Abstract

Individuals with type 2 diabetes are insulin resistant and as a group have a lower exercise capacity (V[O.sub.2max]) than age- and weight-matched people without diabetes (1,2). In this issue, Regensteiner [...]

Published
2005

4. TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle.

Author

Jin-Ho Koh, Johnson, Matthew L., Dasari, Surendra, LeBrasseur, Nathan K., Vuckovic, Ivan, Henderson, Gregory C., Cooper, Shawna A., Manjunatha, Shankarappa, Ruegsegger, Gregory N., Shulman, Gerald I., Lanza, Ian R., Nair, K. Sreekumaran, and Koh, Jin-Ho

Subjects
SKELETAL muscle, INSULIN resistance, KREBS cycle, CITRATE synthase, DNA replication
Abstract

Diet-induced insulin resistance (IR) adversely affects human health and life span. We show that muscle-specific overexpression of human mitochondrial transcription factor A (TFAM) attenuates high-fat diet (HFD)-induced fat gain and IR in mice in conjunction with increased energy expenditure and reduced oxidative stress. These TFAM effects on muscle are shown to be exerted by molecular changes that are beyond its direct effect on mitochondrial DNA replication and transcription. TFAM augmented the muscle tricarboxylic acid cycle and citrate synthase facilitating energy expenditure. TFAM enhanced muscle glucose uptake despite increased fatty acid (FA) oxidation in concert with higher β-oxidation capacity to reduce the accumulation of IR-related carnitines and ceramides. TFAM also increased pAMPK expression, explaining enhanced PGC1α and PPARβ, and reversing HFD-induced GLUT4 and pAKT reductions. TFAM-induced mild uncoupling is shown to protect mitochondrial membrane potential against FA-induced uncontrolled depolarization. These coordinated changes conferred protection to TFAM mice against HFD-induced obesity and IR while reducing oxidative stress with potential translational opportunities. [ABSTRACT FROM AUTHOR]

Published
2019
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5. Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

Author

Schafer, Marissa J., primary, White, Thomas A., additional, Evans, Glenda, additional, Tonne, Jason M., additional, Verzosa, Grace C., additional, Stout, Michael B., additional, Mazula, Daniel L., additional, Palmer, Allyson K., additional, Baker, Darren J., additional, Jensen, Michael D., additional, Torbenson, Michael S., additional, Miller, Jordan D., additional, Ikeda, Yasuhiro, additional, Tchkonia, Tamara, additional, van Deursen, Jan M., additional, Kirkland, James L., additional, and LeBrasseur, Nathan K., additional

Published
2016
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