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Your search keyword '"Inzucchi, Silvio E."' showing total 291 results
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291 results on '"Inzucchi, Silvio E."'

2. Randomized Controlled Trial of the Hemodynamic Effects of Empagliflozin in Patients With Type 2 Diabetes at High Cardiovascular Risk: The SIMPLE Trial

Author

Wolsk, Emil, primary, Jürgens, Mikkel, additional, Schou, Morten, additional, Ersbøll, Mads, additional, Hasbak, Philip, additional, Kjær, Andreas, additional, Zerahn, Bo, additional, Brandt, Niels Høgh, additional, Gæde, Peter Haulund, additional, Rossing, Peter, additional, Faber, Jens, additional, Inzucchi, Silvio E., additional, Kistorp, Caroline Michaela, additional, and Gustafsson, Finn, additional

Published
2022
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3. Speaking to patients about diabetes risk: is terminology important?

Author

Tarasova, Valentina D., Caballero, Jaime A., Turner, Paul, and Inzucchi, Silvio E.

Subjects
Physician and patient, Prediabetic state, Endocrinology -- Terminology, Type 2 diabetes -- Risk factors, Patient education, Health
Abstract

It is estimated that 79 million people in the United States (35% of adults [greater than or equal to] 20 years of age and 50% of adults [greater than or [...]

Published
2014

9. Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort

Author

Rasouli, Neda, Younes, Naji, Utzschneider, Kristina M, Inzucchi, Silvio E, Balasubramanyam, Ashok, Cherrington, Andrea L, Ismail-Beigi, Faramarz, Cohen, Robert M, Olson, Darin E, DeFronzo, Ralph A, Herman, William H, Lachin, John M, Kahn, Steven E, and GRADE Research Group

Subjects
Blood Glucose, Male, C-Peptide, Prevention, Diabetes, Infant, nutritional and metabolic diseases, GRADE Research Group, Medical and Health Sciences, Endocrinology & Metabolism, Cross-Sectional Studies, Clinical Research, Diabetes Mellitus, Humans, Insulin, Female, Insulin Resistance, Child, Preschool, Type 2, Metabolic and endocrine
Abstract

Objective: We investigated sex and racial differences in insulin sensitivity, β-cell function and HbA1c, and the associations with selected phenotypic characteristics. Research Design and Methods: This is a cross-sectional analysis of baseline data from 3,108 GRADE participants. All had type 2 diabetes diagnosed Results: The cohort was 56.6±10 years of age (mean±SD), 63.8% male, with BMI 34.2±6.7 kg/m2, HbA1c 7.5±0.5% and type 2 diabetes duration 4.0±2.8 years. Women had higher DI than men but similar insulin sensitivity. DI was the highest in Black/African Americans, followed by American Indians/Alaska Natives, Asians and Whites in descending order. Compared to white, American Indian/Alaska Native had significantly higher HbA1c but Black/African Americans and Asians had lower HbA1c. However, when adjusted for glucose levels, Black/African Americans had higher HbA1c than whites. Insulin sensitivity correlated inversely with BMI, waist to hip ratio, triglyceride to HDL cholesterol ratio (TG/HDL- C) and the presence of metabolic syndrome; whereas DI was associated directly with age and inversely with BMI, HbA1c and TG/HDL-C. Conclusion: In the GRADE cohort, β-cell function differed by sex and race and was associated with the concurrent level of HbA1c. HbA1c also differed among the races, but not sex. Age, BMI and TG/HDL-C were associated with multiple measures of β-cell function and insulin sensitivity.

Published
2020

10. Elevated Hb[A.sub.1c] and fasting plasma glucose in predicting diabetes incidence among older adults: are two better than one?

Author

Lipska, Kasia J., Inzucchi, Silvio E., Van Ness, Peter H., Gill, Thomas M., Kanaya, Alka, Strotmeyer, Elsa S., Koster, Annemarie, Johnson, Karen C., Goodpaster, Bret H., Harris, Tamara, and De Rekeneire, Nathalie

Subjects
United States. National Institute on Aging -- Analysis, Dextrose -- Analysis, Diabetes -- Analysis, Hypoglycemic agents -- Analysis, Glucose -- Analysis, Glucose metabolism -- Analysis, Health, American Diabetes Association, World Health Organization
Abstract

OBJECTIVE--To determine which measures--impaired fasting glucose (IFG), elevated Hb[A.sub.1c], or both--best predict incident diabetes in older adults. RESEARCH DESIGN AND METHODS--From the Health, Aging, and Body Composition study, we selected [...]

Published
2013
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11. Hb[A.sub.1c] and risk of severe hypoglycemia in type 2 diabetes: the diabetes and aging study

Author

Lipska, Kasia J., Warton, E. Margaret, Huang, Elbert S., Moffet, Howard H., Inzucchi, Silvio E., Krumholz, Harlan M., and Karter, Andrew J.

Subjects
Diabetes therapy, Dextrose, Glucose, Glucose metabolism, Type 2 diabetes -- Research, Health, American Diabetes Association, European Association for the Study of Diabetes
Abstract

OBJECTIVE--We examined the association between Hb[A.sub.1c] level and self-reported severe hypoglycemia in patients with type 2 diabetes. RESEARCH DESIGN AND METNODS--Type 2 diabetic patients in a large, integrated healthcare system, [...]

Published
2013
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12. Dapagliflozin and the Incidence of Type 2 Diabetes in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis From DAPA-HF

Author

Inzucchi, Silvio E, primary, Docherty, Kieran F, primary, Køber, Lars, primary, Kosiborod, Mikhail N, primary, Martinez, Felipe A, primary, Ponikowski, Piotr, primary, Sabatine, Marc S, primary, Solomon, Scott D, primary, Verma, Subodh, primary, Bělohlávek, Jan, primary, Böhm, Michael, primary, Chiang, Chern-En, primary, Boer, Rudolf A. de, primary, Diez, Mirta, primary, Dukát, Andre, primary, Ljungman, Charlotta E.A., primary, Bengtsson, Olof, primary, Langkilde, Anna Maria, primary, Sjöstrand, Mikaela, primary, Jhund, Pardeep S, primary, McMurray, John JV, primary, and Committees, DAPA-HF Investigators and, primary

Published
2020
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13. Dapagliflozin and the Incidence of Type 2 Diabetes in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis From DAPA-HF

Author

Inzucchi, Silvio E., primary, Docherty, Kieran F., additional, Køber, Lars, additional, Kosiborod, Mikhail N., additional, Martinez, Felipe A., additional, Ponikowski, Piotr, additional, Sabatine, Marc S., additional, Solomon, Scott D., additional, Verma, Subodh, additional, Bělohlávek, Jan, additional, Böhm, Michael, additional, Chiang, Chern-En, additional, de Boer, Rudolf A., additional, Diez, Mirta, additional, Dukát, Andre, additional, Ljungman, Charlotta E.A., additional, Bengtsson, Olof, additional, Langkilde, Anna Maria, additional, Sjöstrand, Mikaela, additional, Jhund, Pardeep S., additional, and McMurray, John J.V., additional

Published
2020
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14. Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort

Author

Rasouli, Neda, primary, Younes, Naji, primary, Utzschneider, Kristina M., primary, Inzucchi, Silvio E., primary, Balasubramanyam, Ashok, primary, Cherrington, Andrea L., primary, Ismail-Beigi, Faramarz, primary, Cohen, Robert M., primary, Olson, Darin E., primary, DeFronzo, Ralph A., primary, Herman, William H., primary, Lachin, John M., primary, Kahn, Steven E., primary, and Group, the GRADE Research, primary

Published
2020
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15. The Impact of Empagliflozin on Obstructive Sleep Apnea, Cardiovascular, and Renal Outcomes: An Exploratory Analysis of the EMPA-REG OUTCOME Trial

Author

Neeland, Ian J., primary, Eliasson, Bjorn, primary, Kasai, Takatoshi, primary, Marx, Nikolaus, primary, Zinman, Bernard, primary, Inzucchi, Silvio E., primary, Wanner, Christoph, primary, Zwiener, Isabella, primary, Wojeck, Brian S., primary, Yaggi, Henry K, primary, Johansen, Odd Erik, primary, and investigators, the EMPA-REG OUTCOME®, primary

Published
2020
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16. The Impact of Empagliflozin on Obstructive Sleep Apnea and Cardiovascular and Renal Outcomes: An Exploratory Analysis of the EMPA-REG OUTCOME Trial

Author

Neeland, Ian J., primary, Eliasson, Bjorn, additional, Kasai, Takatoshi, additional, Marx, Nikolaus, additional, Zinman, Bernard, additional, Inzucchi, Silvio E., additional, Wanner, Christoph, additional, Zwiener, Isabella, additional, Wojeck, Brian S., additional, Yaggi, Henry K., additional, and Johansen, Odd Erik, additional

Published
2020
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17. Oral agents for type 2 diabetes: an update

Author

Kimmel, Bonnie and Inzucchi, Silvio E.

Subjects
Insulin -- Dosage and administration -- Research -- Complications and side effects, Hypoglycemic agents -- Dosage and administration -- Complications and side effects -- Research, Type 2 diabetes -- Drug therapy -- Research -- Complications and side effects, Health
Abstract

Type 2 diabetes is a multifactorial metabolic disease characterized by abnormalities at multiple organ sites. These defects include insulin resistance and insulin deficiency. (1,2) The former is primarily represented by [...]

Published
2005

18. Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action

Author

Draznin, Boris, Gilden, Janice, Golden, Sherita H., and Inzucchi, Silvio E.

Subjects
Merck & Company Inc. -- Management, Eli Lilly and Co. -- Management, Sanofi S.A. -- Management, Diabetes therapy, Dextrose, Diabetes, Glucose, Glucose metabolism, Hyperglycemia, Evidence-based medicine, Pharmaceutical industry, Company business management, Health, Endocrine Society -- Management, European Association for the Study of Diabetes -- Management
Abstract

Currently patients with diabetes comprise up to 25-30% of the census of adult wards and critical care units in our hospitals. Although evidence suggests that avoidance of hyperglycemia (> 180 [...]

Published
2013
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19. Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care editors' expert forum

Author

Raz, Itamar, Riddle, Matthew C., Rosenstock, Julio, Buse, John B., Inzucchi, Silvio E., Home, Philip D., Del Prato, Stefano, Ferrannini, Ele, Chan, Juliana C.N., Leiter, Lawrence A., LeRoith, Derek, DeFronzo, Ralph, and Cefalu, William T.

Subjects
Merck & Company Inc. -- Management, Johnson & Johnson -- Management, Bristol-Myers Squibb Co. -- Management, Pfizer Inc. -- Management, Novartis AG -- Management, AstraZeneca PLC -- Management, Eli Lilly and Co. -- Management, Sanofi S.A. -- Management, Diabetes therapy, Editors, Type 2 diabetes -- Care and treatment, Hyperglycemia -- Care and treatment, Pharmaceutical industry, Company business management, Health
Abstract

In June 2012, 13 thought leaders convened in a Diabetes Care Editors' Expert Forum to discuss the concept of personalized medicine in the wake of a recently published American Diabetes [...]

Published
2013
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20. The efficacy and safety of imeglimin as add-on therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy

Author

Fouqueray, Pascale, Pirags, Valdis, Inzucchi, Silvio E., Bailey, Clifford J., Schernthaner, Guntram, Diamant, Michaela, and Lebovitz, Harold E.

Subjects
Metformin -- Dosage and administration -- Complications and side effects, Hypoglycemic agents -- Dosage and administration -- Complications and side effects, Type 2 diabetes -- Drug therapy -- Research, Health
Abstract

OBJECTIVE--A 12-week study assessed the efficacy and safety of a new oral antidiabetic agent, imeglimin, as add-on therapy in type 2 diabetes patients inadequately controlled with metformin alone. RESEARCH DESIGN [...]

Published
2013
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21. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Author

Inzucchi, Silvio E., Bergenstal, Richard M., Buse, John B., Diamant, Michaela, Ferrannini, Ele, Nauck, Michael, Peters, Anne L., Tsapas, Apostolos, Wender, Richard, and Matthews, David R.

Subjects
Merck & Company Inc. -- Management, Johnson & Johnson -- Management, Novartis AG -- Management, Amylin Pharmaceuticals Inc. -- Management, Eli Lilly and Co. -- Management, Sanofi S.A. -- Management, Diabetes -- Research, Type 2 diabetes -- Complications and side effects -- Care and treatment, Hyperglycemia -- Complications and side effects -- Care and treatment, Pharmaceutical industry, Company business management, Health, American Diabetes Association -- Management, European Association for the Study of Diabetes -- Management
Abstract

Glycemic management in type 2 diabetes mellitus has become increasingly complex and, to some extent, controversial, with a widening array of pharmacological agents now available, (1-5) mounting concerns about their [...]

Published
2012
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23. Effect of dapagliflozin in DAPA-HF according to background glucose-lowering therapy

Author

Docherty, Kieran F., primary, Jhund, Pardeep S., primary, Bengtsson, Olof, primary, DeMets, David L., primary, Inzucchi, Silvio E., primary, Køber, Lars, primary, Kosiborod, Mikhail N., primary, Langkilde, Anna Maria, primary, Martinez, Felipe A., primary, Sabatine, Marc S., primary, Sjöstrand, Mikaela, primary, Solomon, Scott D., primary, McMurray, John J.V., primary, and Committees, the DAPA-HF Investigators and, primary

Published
2020
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24. 30-OR: Empagliflozin Delays Need for Insulin Initiation in Patients with Type 2 Diabetes and Cardiovascular Disease: Findings from EMPA-REG OUTCOME

Author

VADUGANATHAN, MUTHIAH, primary, SATTAR, NAVEED, additional, FITCHETT, DAVID H., additional, OFSTAD, ANNE PERNILLE, additional, BRUECKMANN, MARTINA, additional, GEORGE, JYOTHIS T., additional, VERMA, SUBODH, additional, MATTHEUS, MICHAELA, additional, WANNER, CHRISTOPH, additional, INZUCCHI, SILVIO E., additional, ZINMAN, BERNARD, additional, and BUTLER, JAVED, additional

Published
2020
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28. 23-OR: EHR-Based Blood Glucose Alerts Improve Inpatient Glycemic Control at a Large Academic Medical Center

Author

BAK, LEIGH B., primary, FANDEL, THOMAS M., additional, BOZZO, JANIS E., additional, DEWITT, MICHELLE L., additional, CHEN, PING, additional, PANDO, RICHARD A., additional, FERRO, LINDA, additional, KAPLAN, RORY, additional, HENDRICKSON, KARRIE C., additional, AMPORT, STEPHANIE B., additional, SUSSMAN, L. SCOTT, additional, and INZUCCHI, SILVIO E., additional

Published
2020
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29. 1112-P: Does Background T2D Therapy Modify the Benefits of Dapagliflozin in Heart Failure? Analysis of the DAPA-HF Trial

Author

DOCHERTY, KIERAN, primary, INZUCCHI, SILVIO E., additional, KOSIBOROD, MIKHAIL N., additional, KOBER, LARS, additional, LANGKILDE, ANNA MARIA, additional, MARTINEZ, FELIPE, additional, BENGTSSON, OLOF, additional, DEMETS, DAVID L., additional, SJÖSTRAND, MIKAELA, additional, SABATINE, MARC S., additional, SOLOMON, SCOTT, additional, JHUND, PARDEEP, additional, and MCMURRAY, JOHN J., additional

Published
2020
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30. 132-LB: Implications of Initial EGFR Response to Empagliflozin Treatment Effects

Author

INZUCCHI, SILVIO E., primary, KRAUS, BETTINA J., additional, WEIR, MATTHEW R., additional, BAKRIS, GEORGE, additional, MATTHEUS, MICHAELA, additional, CHERNEY, DAVID, additional, SATTAR, NAVEED, additional, HEERSPINK, HIDDO L., additional, RITTER, IVANA, additional, EYNATTEN, MAXIMILIAN VON, additional, ZINMAN, BERNARD, additional, WANNER, CHRISTOPH, additional, and KOITKA-WEBER, AUDREY, additional

Published
2020
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31. 271-OR: ADA Presidents’ Select Abstract: Effect of Dapagliflozin on the Incidence of Diabetes: A Prespecified Exploratory Analysis from DAPA-HF

Author

INZUCCHI, SILVIO E., primary, DOCHERTY, KIERAN, additional, KOBER, LARS, additional, KOSIBOROD, MIKHAIL N., additional, MARTINEZ, FELIPE, additional, PONIKOWSKI, PIOTR, additional, SABATINE, MARC S., additional, SOLOMON, SCOTT, additional, BELOHLAVEK, JAN, additional, BÖHM, MICHAEL, additional, CHIANG, CHERN-EN, additional, DE BOER, RUDOLF A., additional, DIEZ, MIRTA, additional, DUKAT, ANDREJ, additional, LJUNGMAN, CHARLOTTA E.A., additional, VERMA, SUBODH, additional, DEMETS, DAVID L., additional, BENGTSSON, OLOF, additional, LANGKILDE, ANNA MARIA, additional, SJÖSTRAND, MIKAELA, additional, JHUND, PARDEEP, additional, and MCMURRAY, JOHN J., additional

Published
2020
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32. 131-LB: Empagliflozin Reduces the Total Burden of All-Cause Hospitalizations (ACH) and Mortality in EMPA-REG Outcome

Author

INZUCCHI, SILVIO E., primary, ZINMAN, BERNARD, additional, WANNER, CHRISTOPH, additional, FITCHETT, DAVID H., additional, ANKER, STEFAN, additional, POCOCK, STUART, additional, KASPERS, STEFAN, additional, GEORGE, JYOTHIS T., additional, JOHANSEN, ODD ERIK, additional, JAMAL, WAHEED, additional, HANTEL, STEFAN, additional, and LUND, SØREN S., additional

Published
2020
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34. Use of metformin in the setting of mild-to-moderate renal insufficiency

Author

Lipska, Kasia J., Bailey, Clifford J., and Inzucchi, Silvio E.

Subjects
United States. Food and Drug Administration, Hypoglycemic agents, Type 2 diabetes -- Development and progression, Health, American Diabetes Association, European Association for the Study of Diabetes
Abstract

A common clinical conundrum faces all U.S. practitioners treating patients with type 2 diabetes. Today's U.S. Food and Drug Administration prescribing guidelines for metformin contraindicate its use in men and [...]

Published
2011
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36. Five-year outcomes in high-risk participants in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study: a post hoc analysis

Author

Bansal, Shanti, Wackers, Frans J.Th., Inzucchi, Silvio E., Chyun, Deborah A., Davey, Janice A., Staib, Lawrence H., and Young, Lawrence H.

Subjects
Ischemia -- Research, Diabetes -- Research, Diabetics -- Research, Health
Abstract

OBJECTIVE--To estimate baseline cardiovascular risk of 1,123 participants in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study and to assess cardiac event rates and the effect of screening on [...]

Published
2011
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37. The 11-β-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy

Author

Rosenstock, Julio, Banarer, Salomon, Fonseca, Vivian A., Inzucchi, Silvio E., Sun, William, Yao, Wenqing, Hollis, Gregory, Flores, Robert, Levy, Richard, Williams, William V., Seckl, Jonathan R., and Huber, Reid

Subjects
Cholesterol -- Research, Medical research, Medicine, Experimental, Diabetes therapy -- Research, Hypoglycemic agents -- Research, Type 2 diabetes -- Research, Diabetics -- Research, Hyperglycemia -- Research, Cortisone -- Research, Incyte Corp.
Abstract

OBJECTIVE--11-β-hydroxysteroid dehydrogenase type 1 (11βHSD1)converts inactive cortisone into active cortisol, thereby amplifying intracellular glucocorticoid action. The efficacy and safety of the 11βHSD1 inhibitor INCB 13739 were assessed when added to [...]

Published
2010
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38. Aspirin for primary prevention of cardiovascular events in people with diabetes: a position statement of the American Diabetes Association, a scientific statement of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation

Author

Pignone, Michael, Alberts, Mark J., Colwell, John A., Cushman, Mary, Inzucchi, Silvio E., Mukherjee, Debabrata, Rosenson, Robert S., Williams, Craig D., Wilson, Peter W., and Kirkman, M. Sue

Subjects
Antiulcer drugs, Aspirin, Coronary heart disease -- Prevention, Stroke (Disease) -- Prevention, Cardiology, Diabetes -- Prevention, Antilipemic agents, Universities and colleges, Diabetics, Health, American Diabetes Association, American Heart Association
Abstract

The burden of cardiovascular disease (CVD) among patients with diabetes is substantial. Individuals with diabetes are at two- to fourfold increased risk of cardiovascular events compared with age-and sex-matched individuals [...]

Published
2010
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39. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control

Author

Moghissi, Etie S., Korytkowski, Mary T., DiNardo, Monica, Einhorn, Daniel, Hellman, Richard, Hirsch, Irl B., Inzucchi, Silvio E., Ismail-Beigi, Faramarz, Kirkman, M. Sue, and Umpierrez, Guillermo E.

Subjects
Medical research, Medicine, Experimental, Medical societies, Type 2 diabetes, Diabetics -- Diseases, Health, Company business management, Management, Diseases
Abstract

People with diabetes are more likely to be hospitalized and to have longer durations of hospital stay than those without diabetes. A recent survey estimated that 22% of all hospital [...]

Published
2009

40. Resolution of asymptomatic myocardial ischemia in patients with type 2 diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study

Author

Wackers, Frans J. Th., Chyun, Deborah A., Young, Lawrence H., Heller, Gary V., Iskandrian, Ami E., Davey, Janice A., Barrett, Eugene J., Taillefer, Raymond, Wittlin, Steven D., Filipchuk, Neil, Ratner, Robert E., and Inzucchi, Silvio E.

Subjects
Type 2 diabetes -- Complications and side effects -- Diagnosis, Myocardial ischemia -- Diagnosis -- Complications and side effects, Health, Diagnosis, Complications and side effects
Abstract

OBJECTIVE--The purpose of this study was to assess whether the prevalence of inducible myocardial ischemia increases over time in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS--Participants enrolled in [...]

Published
2007

41. Cardiac imaging for risk stratification in diabetes

Author

Bax, Jeroen J., Inzucchi, Silvio E., Bonow, Robert O., Schuijf, Joanne D., Freeman, Michael R., and Barrett, Eugene J.

Subjects
Diabetes -- Health aspects -- Care and treatment -- Risk factors -- Forecasts and trends, Cardiovascular diseases -- Risk factors -- Care and treatment -- Health aspects -- Forecasts and trends, Diabetics -- Health aspects -- Diseases -- Forecasts and trends -- Care and treatment, Health, Market trend/market analysis, Diseases, Care and treatment, Risk factors, Health aspects, Forecasts and trends
Abstract

Worldwide, 200 million individuals currently have diabetes, and projections by the World Health Organization and others suggest that its prevalence will exceed 300 million by 2025 and 360 million by [...]

Published
2007

42. Selling root canals: lessons learned from implementing a hospital insulin infusion protocol

Author

Goldberg, Philip A. and Inzucchi, Silvio E.

Subjects
Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Insulin pumps -- Research -- Health aspects, Critically ill -- Health aspects -- Care and treatment -- Research, Health, Care and treatment, Research, Health aspects
Abstract

In Brief Clinical studies have shown that maintaining normal blood glucose (BG) levels improves clinical outcomes in critically ill patients. However, achieving glycemic control in the hospital is difficult because [...]

Published
2005

43. Insulin-sensitizing antihyperglycemic drugs and mortality after acute myocardial infarction: insights from the National Heart Care Project

Author

Inzucchi, Silvio E., Masoudi, Frederick A., Wang, Yongfei, Kosiborod, Mikhail, Foody, Joanne M., Setaro, John F., Havranek, Edward P., and Krumholz, Harlan M.

Subjects
European Association for the Study of Diabetes -- Case studies, Heart attack -- Case studies, Mortality -- Case studies -- United States, Diabetes -- Case studies, Health, Case studies
Abstract

OBJECTIVE--Thiazolidinediones (TZDs) and metformin are insulin-sensitizing antihyperglycemic agents with reported benefits on atherosclerosis. Despite extensive use in patients with diabetes and cardiovascular disease, there is a paucity of outcomes data [...]

Published
2005

44. Clinical results of an updated insulin infusion protocol in critically ill patients

Author

Goldberg, Philip A., Roussel, Maureen G., and Inzucchi, Silvio E.

Subjects
Terminally ill persons -- Care and treatment -- Health aspects, Insulin -- Dosage and administration -- Health aspects, Blood sugar -- Health aspects, Health
Abstract

Strict glycemic control has recently been shown to improve clinical outcomes in critically ill patients. In the February 2004 issue of Diabetes Care, we reported our early experience implementing an [...]

Published
2005

45. Counterpoint: inpatient glucose management: a premature call to arms?

Author

Inzucchi, Silvio E. and Rosenstock, Julio

Subjects
Diabetes -- Care and treatment -- Research, Glycemic index -- Management -- Research, Health, Company business management, Management, Care and treatment, Research
Abstract

Recently, the attention of the diabetes community has shifted to glycemic management in the inpatient setting, where there has been a rising chorus in support of stricter blood glucose control. [...]

Published
2005

46. Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study

Author

Wackers, Frans J.Th., Young, Lawrence H., Inzucchi, Silvio E., Chyun, Deborah A., Davey, Janice A., Barrett, Eugene J., Taillefer, Raymond, Wittlin, Steven D., Heller, Gary V., Filipchuk, Neil, Engel, Samuel, Ratner, Robert E., and Iskandrian, Ami E.

Subjects
American Diabetes Association -- Research, Yale University. School of Medicine -- Research, Diabetes -- Research, Silent myocardial ischemia -- Research, Asymptotes -- Research, Health, Research
Abstract

OBJECTIVE--To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes Association screening guidelines. [...]

Published
2004

47. Implementation of a safe and effective insulin infusion protocol in a medical intensive care unit

Author

Goldberg, Philip A., Siegel, Mark D., Sherwin, Robert S., Halickman, Joshua I., Lee, Michelle, Bailey, Valerie A., Lee, Sandy L., Dziura, James D., and Inzucchi, Silvio E.

Subjects
Intensive care units -- Comparative analysis -- Case studies -- Health aspects, Blood sugar -- Health aspects -- Case studies -- Comparative analysis, Insulin pumps -- Case studies -- Health aspects -- Comparative analysis, Diabetics -- Health aspects -- Case studies -- Comparative analysis, Health, Case studies, Comparative analysis, Health aspects
Abstract

OBJECTIVE--In a recent randomized controlled trial, lowering blood glucose levels to 80-110 mg/dl improved clinical outcomes in critically ill patients. In that study, the insulin infusion protocol (IIP) used to [...]

Published
2004

48. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

Author

Mayerson, Adam B., Hundal, Ripudaman S., Dufour, Sylvie, Lebon, Vincent, Befroy, Douglas, Cline, Gary W., Enocksson, Staffan, Inzucchi, Silvio E., Shulman, Gerald I., and Petersen, Kitt F.

Subjects
Rosiglitazone maleate -- Evaluation -- Physiological aspects, Insulin -- Physiological aspects -- Evaluation, Triglycerides -- Evaluation -- Physiological aspects, Type 2 diabetes -- Physiological aspects, Lipolysis -- Evaluation -- Physiological aspects, Health, Evaluation, Physiological aspects
Abstract

We examined the effect of three months of rosiglitazone treatment (4 mg b.i.d.) on whole-body insulin sensitivity and in vivo peripheral adipocyte insulin sensitivity as assessed by glycerol release in [...]

Published
2002

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