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Your search keyword '"Distefano, Giovanna"' showing total 6 results
Start Over Author "Distefano, Giovanna" Publisher american diabetes association
6 results on '"Distefano, Giovanna"'

1. Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults with Diabetes

Author

V. Ramos, Sofhia, primary, Distefano, Giovanna, primary, Lui, Li-Yung, primary, M. Cawthon, Peggy, primary, Kramer, Philip, primary, J. Sipula, Ian, primary, M. Bello, Fiona, primary, Mau, Theresa, primary, J. Jurczak, Michael, primary, J. Molina, Anthony, primary, E. Kershaw, Erin, primary, J. Marcinek, David, primary, Shankland, Eric, primary, G.S. Toledo, Frederico, primary, B. Newman, Anne, primary, T. Hepple, Russell, primary, B. Kritchevsky, Stephen, primary, H. Goodpaster, Bret, primary, R. Cummings, Steven, primary, and M. Coen, Paul, primary

Published
2024
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2. Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults with Diabetes

Author

Ramos, Sofhia V., primary, Distefano, Giovanna, additional, Lui, Li-Yung, additional, Cawthon, Peggy M., additional, Kramer, Philip, additional, Sipula, Ian J., additional, Bello, Fiona M., additional, Mau, Theresa, additional, Jurczak, Michael J., additional, Molina, Anthony J., additional, Kershaw, Erin E., additional, Marcinek, David J., additional, Shankland, Eric, additional, Toledo, Frederico G.S., additional, Newman, Anne B., additional, Hepple, Russell T., additional, Kritchevsky, Stephen B., additional, Goodpaster, Bret H., additional, Cummings, Steven R., additional, and Coen, Paul M., additional

Published
2024
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4. Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity

Author

Sitnick, Mitch T., Basantani, Mahesh K., Cai, Lingzhi, Schoiswohl, Gabriele, Yazbeck, Cynthia F., Distefano, Giovanna, Ritov, Vladimir, DeLany, James P., Schreiber, Renate, Stolz, Donna B., Gardner, Noah P., Kienesberger, Petra C., Pulinilkunnil, Thomas, Zechner, Rudolf, Goodpaster, Bret H., Coen, Paul, and Kershaw, Erin E.

Subjects
Obesity -- Complications and side effects, Insulin resistance -- Complications and side effects, Triglycerides -- Health aspects, Muscles -- Health aspects, Health
Abstract

Intramyocellular triacylgiycerol (IMTG) accumulation is highly associated with insulin resistance and metabolic complications of obesity (lipotoxicity), whereas comparable IMTG accumulation in endurance-trained athletes is associated with insulin sensitivity (the athlete's paradox). Despite these findings, it remains unclear whether changes in IMTG accumulation and metabolism per se influence muscle-specific and systemic metabolic homeostasis and insulin responsiveness. By mediating the rate-limiting step in triacylglycerol hydrolysis, adipose triglyceride lipase (ATGL) has been proposed to influence the storage/production of deleterious as well as essential lipid metabolites. However, the physiological relevance of ATGL-mediated triacylglycerol hydrolysis in skeletal muscle remains unknown. To determine the contribution of IMTG hydrolysis to tissue-specific and systemic metabolic phenotypes in the context of obesity, we generated mice with targeted deletion or transgenic overexpression of ATGL exclusively in skeletal muscle. Despite dramatic changes in IMTG content on both chow and high-fat diets, modulation of ATGL-mediated IMTG hydrolysis did not significantly influence systemic energy, lipid, or glucose homeostasis, nor did it influence insulin responsiveness or mitochondrial function. These data argue against a role for altered IMTG accumulation and lipolysis in muscle insulin resistance and metabolic complications of obesity., Obesity is a global public health problem and a major risk factor for insulin resistance and type 2 diabetes. These disorders are characterized by excess lipid accumulation in multiple tissues, [...]

Published
2013
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6. Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery

Author

Coen, Paul M., primary, Menshikova, Elizabeth V., additional, Distefano, Giovanna, additional, Zheng, Donghai, additional, Tanner, Charles J., additional, Standley, Robert A., additional, Helbling, Nicole L., additional, Dubis, Gabriel S., additional, Ritov, Vladimir B., additional, Xie, Hui, additional, Desimone, Marisa E., additional, Smith, Steven R., additional, Stefanovic-Racic, Maja, additional, Toledo, Frederico G.S., additional, Houmard, Joseph A., additional, and Goodpaster, Bret H., additional

Published
2015
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