Author: "Bonora" / Publisher: american diabetes association - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Bonora"' showing total 319 results

Start Over Author "Bonora" Publisher american diabetes association

319 results on '"Bonora"'

1. Hyperglycemia, Reduced Hematopoietic Stem Cells, and Outcome of COVID-19

Author: Bonora, Benedetta Maria, primary, Fogar, Paola, additional, Zuin, Jenny, additional, Falaguasta, Daniele, additional, Cappellari, Roberta, additional, Cattelan, Annamaria, additional, Marinello, Serena, additional, Ferrari, Anna, additional, Avogaro, Angelo, additional, Plebani, Mario, additional, Basso, Daniela, additional, and Fadini, Gian Paolo, additional
Published: 2022
Full Text: View/download PDF

2. Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study

Author: Rossing, Peter, primary, Burgess, Ellen, additional, Agarwal, Rajiv, additional, Anker, Stefan D., additional, Filippatos, Gerasimos, additional, Pitt, Bertram, additional, Ruilope, Luis M., additional, Gillard, Pieter, additional, MacIsaac, Richard J., additional, Wainstein, Julio, additional, Joseph, Amer, additional, Brinker, Meike, additional, Roessig, Lothar, additional, Scott, Charlie, additional, Bakris, George L., additional, Vallejos, Augusto, additional, MacIsaac, Richard, additional, Schernthaner, Guntram, additional, Canziani, Maria Eugenia F., additional, Temelkova-Kurktschiev, Theodora, additional, Tobe, Sheldon, additional, González, Fernando, additional, Liu, Zhi-Hong, additional, Ángelo, Andrés, additional, Bonfanti, Cadena, additional, Francisco Jaramillo, Carlos, additional, Prazny, Martin, additional, Rossing, Peter, additional, Strand, Jorma, additional, Marre, Michel, additional, Schmieder, Roland, additional, Wanner, Christoph, additional, Sarafidis, Pantelis A., additional, Chan, Juliana, additional, Rosivall, László, additional, Eustace, Joseph, additional, Grossman, Ehud, additional, Yagil, Yoram, additional, Remuzzi, Giuseppe, additional, Koya, Daisuke, additional, Wada, Takashi, additional, Madero Rovalo, Magdalena, additional, Gansevoort, Ron, additional, Kooy, Adriaan, additional, Finnes, Trine, additional, De Leon, Froilan, additional, Gumprecht, Janusz, additional, Teixeira e Costa, Fernando, additional, Dreval, Alexander, additional, Vathsala, Anantharaman, additional, Amod, Aslam, additional, Gon Kim, Sin, additional, Wan Lee, Byung, additional, Pascual Santos, Julio, additional, Tengmark, Bengt-Olov, additional, Burnier, Michel, additional, Lee, Chien-Te, additional, Yamwong, Sukit, additional, Sari, Ramazan, additional, McCafferty, Kieran, additional, Mankovsky, Borys, additional, Adler, Sharon, additional, Fried, Linda, additional, Toto, Robert, additional, Williams, Mark, additional, Quang Khanh, Tran, additional, Aizenberg, Diego, additional, Bartolacci, Inés, additional, Besada, Diego, additional, Bittar, Julio, additional, Chahin, Mariano, additional, Elbert, Alicia, additional, Gelersztein, Elizabeth, additional, Liberman, Alberto, additional, Maffei, Laura, additional, Pérez Manghi, Federico, additional, Sanabria, Hugo, additional, Viñes, Gloria, additional, Wassermann, Alfredo, additional, Abhayaratna, Walter, additional, Acharya, Shamasunder, additional, Ekinci, Elif, additional, Lee, Darren, additional, Mann Mah, Peak, additional, Nelson, Craig, additional, Packham, David, additional, Pape, Alexia, additional, Roger, Simon, additional, Stephenson, Hugo, additional, Suranyi, Michael, additional, Wittert, Gary, additional, Vale, Elizabeth, additional, Clodi, Martin, additional, Ebenbichler, Christoph, additional, Fliesser-Görzer, Evelyn, additional, Hanusch, Ursula, additional, Krebs, Michael, additional, Lhotta, Karl, additional, Ludvik, Bernhard, additional, Mayer, Gert, additional, Neudorfer, Peter, additional, Paulweber, Bernhard, additional, Prager, Rudolf, additional, Preiß, Wolfgang, additional, Prischl, Friedrich, additional, Schernthaner, Gerit-Holger, additional, Sourij, Harald, additional, Wiesholzer, Martin, additional, Doubel, Peter, additional, Engelen, Wendy, additional, Hougardy, Jean-Michel, additional, Krzesinski, Jean-Marie, additional, Maes, Bart, additional, Speeckaert, Marijn, additional, Stas, Koen, additional, van Gaal, Luc, additional, Vanbelleghem, Hilde, additional, Antunes, Daniela, additional, Botelho, Roberto, additional, Brito, Claudia, additional, Canani, Luis, additional, Eugenia Canziani, Maria, additional, Cerqueira, Maria, additional, de Paula, Rogerio, additional, Eliaschewitz, Freddy, additional, Eduardo Figueiredo, Carlos, additional, Forti, Adriana, additional, Hissa, Miguel, additional, Leite Jr, Maurilo, additional, Lima, Emerson, additional, Noronha, Irene, additional, Paolino, Bruno, additional, Paschoalin, Nathalia, additional, Paschoalin, Raphael, additional, Pecoits Filho, Roberto, additional, Pereira, Marcio, additional, Portes, Evandro, additional, Precoma, Dalton, additional, Rea, Rosangela, additional, Riella, Miguel, additional, Eduardo Salles, Joao, additional, Vasconcellos, Eduardo, additional, Vencio, Sergio, additional, Apostolova, Emiliya, additional, Boshnyashka, Radostina, additional, Farah, Ghassan, additional, Georgiev, Dimitar, additional, Gushterova, Valentina, additional, Klyuchkova, Neli, additional, Lucheva, Mariya, additional, Manova, Petya, additional, Minkova, Dotska, additional, Nonchev, Boyan, additional, Pichmanova, Mariyana, additional, Prakova, Zhulieta, additional, Rangelov, Rangel, additional, Rashkov, Rosen, additional, Stanchev, Pavel, additional, Stoyanovska-Elencheva, Bilyana, additional, Tagarev, Zhivko, additional, Temelkova-Kurktschieva, Theodora, additional, Vasileva, Svetla, additional, Yoncheva-Mihaylova, Mariana, additional, Barre, Paul, additional, Carlson, Brian, additional, Conway, James, additional, Cournoyer, Serge, additional, Dumas, Richard, additional, Fikry, Sameh, additional, Goluch, Richard, additional, Hamet, Pavel, additional, Hart, Randolph, additional, Henein, Sam, additional, Liutkus, Joanne, additional, Madore, Francois, additional, Martinho, Valdemar, additional, Mazza, Giuseppe, additional, McFarlane, Philip, additional, O'Keefe, Dennis, additional, Peterson, Sean, additional, Schwartz, Daniel, additional, Shu, Daniel, additional, Steele, Andrew, additional, Tellier, Guy, additional, Tennankore, Karthik, additional, Tsoukas, George, additional, Tytus, Richard, additional, Vitou, Louise, additional, Walsh, Michael, additional, Weisnagel, Stanley, additional, Wilderman, Igor, additional, Yale, Jean-Francois, additional, Cobos, Jorge, additional, Godoy, Juan, additional, Lobos, Sergio, additional, Carlos Palma, Juan, additional, Carlos Prieto, Juan, additional, Reyes, Eliana, additional, Romero, Carmen, additional, Saavedra, Victor, additional, Vega, Mario, additional, Bu, Ruifang, additional, Cai, Hanqing, additional, Chen, Nan, additional, Chen, Qinkai, additional, Chen, Dejun, additional, Cheng, Jinluo, additional, Dong, Youping, additional, Dong, Junwu, additional, Guan, Tianjun, additional, Hao, Chuanming, additional, Huang, Wen, additional, Jiang, Fangfang, additional, Lei, Minxiang, additional, Li, Ling, additional, Li, Zhonghe, additional, Li, Xuemei, additional, Li, Jingmei, additional, Li, Yan, additional, Liang, Xinling, additional, Liang, Bo, additional, Liu, Fang, additional, Liu, Yinghong, additional, Liu, Yuantao, additional, Liu, Zhihong, additional, Long, Gang, additional, Lu, Guoyuan, additional, Lu, Weiping, additional, Lu, Yibing, additional, Luo, Ping, additional, Ma, Jianhua, additional, Mo, Zhaohui, additional, Niu, Jianying, additional, Peng, Ai, additional, Shen, Jiansong, additional, Shen, Feixia, additional, Shi, Bingyin, additional, Su, Qing, additional, Sun, Zhuxing, additional, Tang, Shuifu, additional, Tong, Nanwei, additional, Wang, Hao, additional, Wang, Xinjun, additional, Wang, Lihua, additional, Wang, Guixia, additional, Wang, Jianqin, additional, Wang, Yangang, additional, Wang, Li, additional, Wei, Jiali, additional, Wu, Tianfeng, additional, Wu, Chaoqing, additional, Xing, Changying, additional, Xiong, Fei, additional, Xu, Xudong, additional, Xu, Ning, additional, Yan, Tiekun, additional, Yang, Jinkui, additional, Yin, Aiping, additional, Zeng, Longyi, additional, Zhang, Hao, additional, Zhang, Yanlin, additional, Zhang, Ying, additional, Zhao, Wenjing, additional, Zhao, Zhiquan, additional, Zheng, Hongguang, additional, Zhong, Ling, additional, Zhu, Dalong, additional, Zhuang, Yongze, additional, Arango, Clara, additional, Barrera, Sandra, additional, Beltrán López, Nelly, additional, Benitez, Diego, additional, Blanco, Guillermo, additional, Cadena, Andrés, additional, Coronel, Julian, additional, Cure, Carlos, additional, Durán, Carlos, additional, González, Alexander, additional, Guzmán, Gustavo, additional, Hernández, Eric, additional, Ibarra, Jaime, additional, Jaramillo, Carlos, additional, Jaramillo, Nicolás, additional, Kattah, William, additional, Molina, Dora, additional, Sánchez, Gregorio, additional, Terront, Mónica, additional, Trujillo, Freddy, additional, Urina, Miguel, additional, Vargas, Ruben, additional, Villegas, Iván, additional, Yupanqui, Hernán, additional, Alferi, Dino, additional, Brada, Michal, additional, Brezina, Jiri, additional, Bucek, Petr, additional, Edelsberger, Tomas, additional, Gulakova, Drahomira, additional, Hasalova Zapletalova, Jitka, additional, Hola, Olga, additional, Hornova, Lucie, additional, Houdova, Jana, additional, Hrmova, Helena, additional, Karasek, David, additional, Kopecka, Sarka, additional, Kovar, Richard, additional, Krcova, Eva, additional, Kuchar, Jiri, additional, Kutejova, Vlasta, additional, Lubanda, Hana, additional, Matyasek, Ivo, additional, Mokrejsova, Magdalena, additional, Okenka, Libor, additional, Pumprla, Jiri, additional, Tomanek, Pavel, additional, Bech, Jesper, additional, Faber, Jens, additional, Gislason, Gunnar, additional, Hangaard, Jørgen, additional, Jaroslaw Pacyk, Grzegorz, additional, Juhl, Claus, additional, Krarup, Thure, additional, Lindhardt, Morten, additional, Madsbad, Sten, additional, Nielsen, Joan, additional, Pedersen-Bjergaard, Ulrik, additional, Poulsen, Per, additional, Rasmussen, Ole, additional, Schousboe, Karoline, additional, Honkasalo, Mikko, additional, Humaloja, Kari, additional, Kananen, Kristiina, additional, Kantola, Ilkka, additional, Koistinen, Arvo, additional, Korsoff, Pirkko, additional, Lahtela, Jorma, additional, Nieminen, Sakari, additional, Nieminen, Tuomo, additional, Sadeharju, Karita, additional, Sulosaari, Sakari, additional, Cariou, Bertrand, additional, Chantrel, François, additional, Clavel, Sylvaine, additional, Combe, Christian, additional, Fauvel, Jean-Pierre, additional, Gallouj, Karim, additional, Gouet, Didier, additional, Guerci, Bruno, additional, Guerrot, Dominique, additional, Hourmant, Maryvonne, additional, Klein, Alexandre, additional, Mariat, Christophe, additional, Mesbah, Rafik, additional, Le Meur, Yannick, additional, Monier, Arnaud, additional, Moranne, Olivier, additional, Serusclat, Pierre, additional, Vendrely, Benoit, additional, Verges, Bruno, additional, Zaoui, Philippe, additional, Axthelm, Christoph, additional, Bergmann, Andreas, additional, Birkenfeld, Andreas L., additional, Braun, Hermann, additional, Busch, Klaus, additional, Contzen, Christel, additional, Degenhardt, Stefan, additional, Derwahl, Karl, additional, Giebel, Thomas, additional, Hagenow, Andreas, additional, Haller, Hermann, additional, Hasslacher, Christoph, additional, Horacek, Thomas, additional, Jungmair, Wolfgang, additional, Kloos, Christof, additional, Koch, Thorsten, additional, Krüger, Thilo, additional, Mühlfeld, Anja, additional, Müller, Joachim, additional, Pfützner, Andreas, additional, Pistrosch, Frank, additional, Rose, Ludger, additional, Rump, Lars, additional, Schettler, Volker, additional, Schiefke, Ingolf, additional, Schlichthaar, Heike, additional, Schröppel, Bernd, additional, Schürholz, Thomas, additional, Sigal, Helena, additional, Stemler, Lutz, additional, Strack, Georg, additional, Täschner, Heidrun, additional, Toursarkissian, Nicole, additional, Tschöpe, Diethelm, additional, Ulmer, Achim, additional, van der Giet, Markus, additional, Winkelmann, Bernhard R., additional, Boletis, Ioannis, additional, Hatziagelaki, Erifili, additional, Ioannidis, Ioannis, additional, Kounadi, Theodora, additional, Makriniotou, Ioanna, additional, Papadopoulou, Dorothea, additional, Papagianni, Aikaterini, additional, Passadakis, Ploumis, additional, Stefanidis, Ioannis, additional, Pang Ip, Tai, additional, Lee, Paul, additional, Yan Andrea Luk, On, additional, Wang, Angela, additional, Yeung, Vincent, additional, Bajcsi, Dora, additional, Danos, Peter, additional, Harcsa, Eleonora, additional, Kazup, Szilvia, additional, Keltai, Katalin, additional, Kirschner, Robert, additional, Kiss, Julianna, additional, Kovacs, Laszlo, additional, Lamboy, Beata, additional, Literati-Nagy, Botond, additional, Mileder, Margit, additional, Nagy, Laszlo, additional, Noori, Ebrahim, additional, Nyirati, Gabor, additional, Petro, Gizella, additional, Schneider, Karoly, additional, Szocs, Albert, additional, Vasas, Szilard, additional, Wudi, Krisztina, additional, Zilahi, Zsolt, additional, Zsom, Marianna, additional, Eustace, Joe, additional, Holian, John, additional, Reddan, Donal, additional, O'Meara, Yvonne, additional, Abramof Ness, Rosane, additional, Adawi, Faiad, additional, Armaly, Zaher, additional, Atar, Shaul, additional, Ben Chetrit, Sydney, additional, Berar Yanay, Noa, additional, Chernin, Gil, additional, Darawsha, Mahmud, additional, Efrati, Shai, additional, Elias, Mazen, additional, Farber, Evgeny, additional, Glandt, Mariela, additional, Halabi, Majdi, additional, Khazim, Khaled, additional, Liberty, Idit, additional, Mosenzon, Ofri, additional, Nimer, Assy, additional, Schwartz, Doron, additional, Zukermann, Robert, additional, Ilieva Parvanova, Aneliya, additional, Avogaro, Angelo, additional, Giorgio Battaglia, Giovanni, additional, Tiziano Bevilacqua, Maurizio, additional, Bonora, Enzo, additional, Antonio Bossi, Carlo, additional, Calabrò, Paolo, additional, Luigi Cavalot, Franco, additional, Cimino, Roberto, additional, Gennaro Cozzolino, Mario, additional, David, Salvatore, additional, Emdin, Michele, additional, Fiaccadori, Enrico, additional, Fiorina, Paolo, additional, Bruno Giorda, Carlo, additional, Cristina Gregorini, Maria, additional, La Manna, Gaetano, additional, Carlo Maggi, Davide, additional, Manti, Roberta, additional, Meregalli, Giancarla, additional, Pani, Antonello, additional, Perico, Norberto, additional, Piatti, PierMarco, additional, Pisani, Antonio, additional, Ettore Pontiroli, Antonio, additional, Ponzani, Paola, additional, Santorelli, Gennaro, additional, Santoro, Domenico, additional, Scanziani, Renzo, additional, Teatini, Ugo, additional, Tonolo, Giancarlo, additional, Trevisan, Roberto, additional, Maria Veronelli, Anna, additional, Luciano Viviani, Giorgio, additional, Araki, Hideo, additional, Ebisui, Osamu, additional, Fujita, Naruhiro, additional, Furuya, Ryuichi, additional, Hamamoto, Yoshiyuki, additional, Hatazaki, Masahiro, additional, Hayashi, Terumasa, additional, Higashi, Takayuki, additional, Hirohata, Yoshihide, additional, Horinouchi, Shuji, additional, Inagaki, Masayuki, additional, Ishii, Masao, additional, Ishiko, Tamayo, additional, Jinnouchi, Hideaki, additional, Kanai, Hidetoshi, additional, Kanda, Daisuke, additional, Kanehara, Hideo, additional, Kashima, Masayuki, additional, Kato, Kiyoe, additional, Katsuki, Takeshi, additional, Kawamitsu, Katsunori, additional, Kawasaki, Satsuki, additional, Kikuchi, Fumi, additional, Kikuchi, Hidetoshi, additional, Kobayashi, Kunihisa, additional, Koide, Junko, additional, Kubota, Miyuki, additional, Kusano, Yoshiro, additional, Maeda, Hajime, additional, Matsubayashi, Sunao, additional, Matsumoto, Kazunari, additional, Matsuo, Yasuto, additional, Matsuoka, Naoki, additional, Miyaoka, Hiroaki, additional, Murao, Satoshi, additional, Nakayama, Mikihiro, additional, Nakazawa, Jun, additional, Nomiyama, Takashi, additional, Noritake, Masayuki, additional, Ogiwara, Takayuki, additional, Ohashi, Hiroshi, additional, Okamoto, Hideki, additional, Osonoi, Takeshi, additional, Sasaki, Nobuhiro, additional, Sekigami, Taiji, additional, Shibasaki, Taro, additional, Shibata, Hirotaka, additional, Shinoda, Junji, additional, Sobajima, Hiroshi, additional, Sugitatsu, Kazuya, additional, Sugiura, Toshiyuki, additional, Sugiyama, Toru, additional, Suzuki, Daisuke, additional, Suzuki, Hiroyuki, additional, Suzuki, Masaaki, additional, Takeda, Asami, additional, Tanaka, Asami, additional, Tanaka, Seiichi, additional, Tsunematsu, Izumi, additional, Ujihara, Makoto, additional, Yamada, Daishiro, additional, Yamada, Masayo, additional, Yamagata, Kazuo, additional, Yamakawa, Ken, additional, Yamakawa, Fumiko, additional, Yamasaki, Yoshimitsu, additional, Yambe, Yuko, additional, Yanagida, Taihei, additional, Yanai, Hidekatsu, additional, Yasuda, Tetsuyuki, additional, Kriauciuniene, Dovile, additional, Lasiene, Jurate, additional, Navickas, Antanas, additional, Radzeviciene, Lina, additional, Urbanaviciene, Egle, additional, Urbonas, Gediminas, additional, Velaviciene, Audrone, additional, Abd Ghani, Rohana, additional, Azizah Aziz, Nor, additional, Yuan Lee, Li, additional, Loong Loh, Chek, additional, Mohd Ali, Norhaliza, additional, Mohd Noor, Nurain, additional, Nur Fatnoon, Nik, additional, Ahmad, Nik, additional, Ratnasingam, Jeyakantha, additional, Hasnul Halimi Bin, Wan, additional, Hasan, Wan, additional, Mohd Izani, Wan, additional, Mohamed, Wan, additional, Avila Pardo, Sandro, additional, Bastidas Adrian, Miriam, additional, Chew Wong, Alfredo, additional, Escobedo de la Peña, Jorge, additional, Fanghänel Salmón, Guillermo, additional, González Gálvez, Guillermo, additional, Gutiérrez Ochoa, Ramiro, additional, Irizar Santana, Saúl, additional, Méndez Machado, Gustavo, additional, Nevarez Ruiz, Luis, additional, Ramos Ibarra, Denisse, additional, Ramos López, Gabriel, additional, Sauque Reyna, Leobardo, additional, Solache Ortiz, Gustavo, additional, Valdez Ortiz, Rafael, additional, Villagordoa Mesa, Juan, additional, Bakker, R.C., additional, Barendregt, J.N.M., additional, Boonstra, A.H., additional, Bos, Willem, additional, Brouwer, C.B., additional, van Buren, M., additional, Krekels, Marielle, additional, van Leendert, Ruud J.M., additional, Lieverse, Louis A.G., additional, Luik, P.T., additional, Lars Penne, E., additional, Smak Gregoor, Peter, additional, Vogt, Liffert, additional, Baker, John, additional, Crawford, Veronica, additional, Cutfield, Rick, additional, Dunn, Peter, additional, Krebs, Jeremy, additional, Nirmalaraj, Kingsley, additional, Scott, Russell, additional, Smuts, Nine, additional, Eriksen, Erik, additional, Høivik, Hans, additional, Karlsson, Thomas, additional, Scott Munk, Peter, additional, Radtke, Maria, additional, Risberg, Knut, additional, Rocke, Jan, additional, Solnør, Leidulv, additional, Stenehjem, Aud-Eldrid, additional, Tafjord, Anne-Beathe, additional, Pamugas, Glenda, additional, Panelo, Araceli, additional, Perez, Ronald, additional, Tanque, Maribel, additional, Tirador, Louie, additional, Villa, Michael, additional, Butrymowicz, Patrycja, additional, Ciechanowski, Kazimierz, additional, Cieslik, Grazyna, additional, Franek, Edward, additional, Hoffmann, Michal, additional, Krzykowska, Jolanta, additional, Kurnatowska, Ilona, additional, Landa, Katarzyna, additional, Madrzejewski, Adam, additional, Madziarska, Katarzyna, additional, Mazur, Stanislaw, additional, Napora, Piotr, additional, Nowicki, Michal, additional, Ocicka-Kozakiewicz, Anna, additional, Rewerska, Barbara, additional, Rusicka, Teresa, additional, Ruxer, Jan, additional, Skokowska, Ewa, additional, Stankiewicz, Andrzej, additional, Stompor, Tomasz, additional, Tiuryn-Petrulewicz, Agnieszka, additional, Wasilewska, Katarzyna, additional, Wierusz-Wysocka, Bogna, additional, Wnetrzak-Michalska, Renata, additional, Almeida, Edgar, additional, Ballesteros, Rosa, additional, Barreto, Carlos, additional, Beirao, Idalina, additional, Birne, Rita, additional, Esteves, Cesar, additional, Guia, Jose, additional, Heitor, Susana, additional, Marques, Olinda, additional, Melo, Pedro, additional, Nolasco, Fernando, additional, Pereira, Amalia, additional, Roque, Cristina, additional, Rosario, Francisco, additional, Silva, Gil, additional, Silva, Ana, additional, Vila Lobos, Ana, additional, Cortes-Maisonet, Gregorio, additional, Roman-Miranda, Amaury, additional, Albota, Adrian, additional, Bala, Cornelia, additional, Barbonta, Hortensia, additional, Caceaune, Elena, additional, Catrinoui, Doina, additional, Constantin, Ciprian, additional, Dumitrescu, Adriana, additional, Mindrescu, Nicoleta, additional, Mistode, Cristina, additional, Negrisanu, Gabriela, additional, Onaca, Adriana, additional, Paveliu, Silvia, additional, Pintilei, Ella, additional, Pop, Lavinia, additional, Popa, Amorin, additional, Popescu, Alexandrina, additional, Radulian, Gabriela, additional, Szilagyi, Iosif, additional, Turcu, Liana, additional, Vacaru, Georgeta, additional, Vlad, Adrian, additional, Antsiferov, Mikhail, additional, Arkhipov, Mikhail, additional, Babkin, Andrey, additional, Barbarash, Olga, additional, Baranov, Vitaliy, additional, Chernyavskaya, Elena, additional, Demko, Arkadiy, additional, Edin, Anton, additional, Ermakova, Polina, additional, Fadeev, Valentin, additional, Galyavich, Albert, additional, Gaysina, Leyla, additional, Gordeev, Ivan, additional, Ipatko, Irina, additional, Kalashnikova, Marina, additional, Khalimov, Yuriy, additional, Klimontov, Vadim, additional, Kobalava, Zhanna, additional, Kosmacheva, Elena, additional, Koziolova, Natalya, additional, Kvitkova Sergey Levashov, Lyudmila, additional, Libis, Roman, additional, Marasaev, Vyacheslav, additional, Malykh, Natalia, additional, Martynenko, Vladimir, additional, Malyutina, Sofya, additional, Merai, Imad, additional, Mkrtumyan, Ashot, additional, Nechaeva, Galina, additional, Petunina, Nina, additional, Palyutin, Shamil, additional, Pimenov, Leonid, additional, Rechkova, Elena, additional, Rodionova, Tatyana, additional, Rymar, Oksana, additional, Sardinov, Ruslan, additional, Semenova, Olga, additional, Sherenkov, Alexander, additional, Solovev, Oleg, additional, Smolyarchuk, Elena, additional, Strongin, Leonid, additional, Ukhanova, Olga, additional, Verlan, Nadezhda, additional, Vorokhobina, Natalya, additional, Yakhontov, Davyd, additional, Yakushin, Sergey, additional, Zakharova, Elena, additional, Zalevskaya, Alsu, additional, Zanozina, Olga, additional, Zhdanova, Elena, additional, Zhukova, Larisa, additional, Zykova, Tatyana, additional, Fang Sum, Chee, additional, Muhummad Suhail, Sufi, additional, San Tan, Ru, additional, Wong, Edmund, additional, Babikova, Jana, additional, Buganova, Ingrid, additional, Dzupina, Andrej, additional, Ochodnicka, Zuzana, additional, Sosovec, Dalibor, additional, Spodniakova, Denisa, additional, Ahmed, Fayzal, additional, Bhana, Sindeep, additional, Distiller, Larry, additional, Jansen van Rensburg, Dirkie, additional, Joshi, Mukesh, additional, Joshi, Shaifali, additional, Lakha, Deepak, additional, Mitha, Essack, additional, Podgorski, Gracjan, additional, Ranjith, Naresh, additional, Rayner, Brian, additional, Rheeder, Paul, additional, Sarvan, Mohamed, additional, Seeber, Mary, additional, Siebert, Heidi, additional, Tayob, Mohammed, additional, Trokis, Julien, additional, Urbach, Dorothea, additional, van Zyl, Louis, additional, Choi, Bum-Soon, additional, Gi Choi, Moon, additional, Chung, ChoonHee, additional, Hwang, YouCheol, additional, Kim, ChongHwa, additional, Kim, InJoo, additional, Kim, JaeHyeon, additional, Kim, SinGon, additional, Kim, SungGyun, additional, Hee Kim, Tae, additional, Lee, WooJe, additional, Lee, ByungWan, additional, Wook Lee, Kang, additional, Oh, Kook-Hwan, additional, Eun Oh, Ji, additional, Kyu Oh, Yun, additional, Oh, Dong-Jin, additional, Park, Junbeom, additional, Joon Shin, Seok, additional, Sung, Su-Ah, additional, Myung Yu, Jae, additional, Agraz, Irene, additional, Javier Ampudia, Francisco, additional, Bouarich, Hanane, additional, Calero, Francesca, additional, Castro, Cristina, additional, Cigarrán Guldris, Secundino, additional, Cruzado Garrit, Josep, additional, de Álvaro, Fernando, additional, Galcerán, Josep, additional, González Albarrán, Olga, additional, Hernández Jaras, Julio, additional, Ibernón, Meritxell, additional, Martínez Deben, Francisco, additional, Dolores Martínez Esteban, Ma, additional, María Pascual Izuel, José, additional, Martins, Judith, additional, Mediavilla, Juan, additional, Michán, Alfredo, additional, Poch, Esteban, additional, Polaina Rusillo, Manuel, additional, Sánchez Juan, Carlos, additional, Santamaría Olmo, Rafael, additional, Julián, José, additional, de la Morena, Segura, additional, Soto, Alfonso, additional, Troya, Maribel, additional, Bruchfeld, Annette, additional, Curiac, Dan, additional, Eliasson, Ken, additional, Frank, Malin, additional, Guron, Gregor, additional, Hellberg, Olof, additional, Hellgren, Margareta, additional, Larnefeldt, Hans, additional, Lindholm, Carl-Johan, additional, Löndahl, Magnus, additional, Rein-Hedin, Erik, additional, Soveri, Inga, additional, Spaak, Jonas, additional, Ackermann, Daniel, additional, Bilz, Stefan, additional, Forster, Christian, additional, Kalbermatter, Stefan, additional, Kistler, Andreas, additional, Pechére-Bertschi, Antoinette, additional, Schultes, Bernd, additional, Chang, Chiz-Tzung, additional, Hung, Cheng-Chieh, additional, Jiang, Ju-Ying, additional, Lin, Shuei-Liong, additional, Tarng, Der-Cherng, additional, Tu, Shih-Te, additional, Wu, Mai-Szu, additional, Wu, Ming-Ju, additional, Deerochanawong, Chaicharn, additional, Kitiyakara, Chagriya, additional, Ophascharoensuk, Vuddhidej, additional, Pongchaiyakul, Chatlert, additional, Satirapoj, Bancha, additional, Eren, Necmi, additional, Gul, Ibrahim, additional, Gulel, Okan, additional, Kocyigit, Ismail, additional, Kumbasar, Abdulbaki, additional, Sahin, Idris, additional, Sayin, Burak, additional, Tavli, Talat, additional, Ustundag, Sedat, additional, Yenicerioglu, Yavuz, additional, Bondarets, Iryna, additional, Botsyurko, Volodymyr, additional, Chernikova, Viktoriia, additional, Donets, Oleksandra, additional, Fushtey, Ivan, additional, Grachova, Mariia, additional, Isayeva, Anna, additional, Kogut, Dmytro, additional, Komisarenko, Julia, additional, Kravchun, Nonna, additional, Malyar, Kateryna, additional, Martynyuk, Liliya, additional, Maslyanko, Vitaliy, additional, Myshanych, Halyna, additional, Pererva, Larysa, additional, Pertseva, Nataliia, additional, Serhiyenko, Oleksandr, additional, Smirnov, Ivan, additional, Sokolova, Liubov, additional, Stryzhak, Vasyl, additional, Vlasenko, Maryna, additional, AbouSaleh, Ahmad, additional, Barratt, Jonathan, additional, Dang, Cuong, additional, Kahal, Hassan, additional, Kirk, Adam, additional, Kilvert, Anne, additional, Phi Kon, Sui, additional, Patel, Dipesh, additional, Rice, Sam, additional, Vijayaraman, Arutchelvam, additional, Wong, Yuk-ki, additional, Gibson, Martin, additional, Wahba, Mona, additional, Zaidi, Reza, additional, Acosta, Idalia, additional, Adams, Atoya, additional, Ajani, Dilawar, additional, Ali, Slamat, additional, Alicic, Radica, additional, Al-Karadsheh, Amer, additional, Alla, Sreedhara, additional, Allison, D., additional, Andrawis, Nabil, additional, Arif, Ahmed, additional, Awad, Ahmed, additional, Azizad, Masoud, additional, Bahrami, Michael, additional, Bansal, Shweta, additional, Barag, Steven, additional, Barakzoy, Ahmad, additional, Barney, Mark, additional, Barzilay, Joshua, additional, Bashir, Khalid, additional, Bautista, Jose, additional, Beddhu, Srinivasan, additional, Belo, Diogo, additional, Benjamin, Sabrina, additional, Berenji, Ramin, additional, Bhargava, Anuj, additional, Birriel, Jose, additional, Brietzke, Stephen, additional, Brosius, Frank, additional, Brusco, Osvaldo, additional, Burgner, Anna, additional, Busch, Robert, additional, Canadas, Rafael, additional, Caramori, Maria, additional, Cardona, Jose, additional, Case, Christopher, additional, Cruz, Humberto, additional, Dandillaya, Ramprasad, additional, Dawoud, Dalia, additional, Din, Zia, additional, Dixon, Bradley, additional, Doshi, Ankur, additional, Drakakis, James, additional, El Shahawy, Mahfouz, additional, El-Meanawy, Ashraf, additional, El-Shahawy, Mohammed, additional, Evans, John, additional, Fadda, George, additional, Farooq, Umar, additional, Fernando, Roland, additional, Fink, Raymond, additional, First, Brian, additional, Fitz-Patrick, David, additional, Flack, John, additional, Fluck, Patrick, additional, Fogelfeld, Leon, additional, Fonseca, Vivian, additional, Frias, Juan, additional, Galphin, Claude, additional, Garcia-Mayol, Luis, additional, Goldstein, Gary, additional, Gonzalez, Edgar, additional, Gonzalez-Abreu, Francisco, additional, Gore, Ashwini, additional, Grant, David, additional, Habwe, Violet, additional, Hamilton, Maxine, additional, Hammoud, Jamal, additional, Handelsman, Stuart, additional, Hartman, Israel, additional, Heigerick, Glenn, additional, Henry, Andrew, additional, Hernandez, German, additional, Hernandez-Cassis, Carlos, additional, Herrera, Carlos, additional, Hertel, Joachim, additional, Huang, Wenyu, additional, Iglesias, Rogelio, additional, Iranmanesh, Ali, additional, Jackson, Timothy, additional, Jain, Mahendra, additional, Jamerson, Kenneth, additional, Johnson, Karen, additional, Judd, Eric, additional, Kaplan, Joshua, additional, Kayali, Zeid, additional, Khan, Bobby, additional, Khan, Muhammad, additional, Kharait, Sourabh, additional, Sue Kirkman, M., additional, Kopyt, Nelson, additional, Kotzker, Wayne, additional, Kovesdy, Csaba, additional, Kreit, Camil, additional, Krishna, Arvind, additional, Kronfli, Saeed, additional, Lee, Keung, additional, LeJeune, Derek, additional, Lemus, Brenda, additional, Leon-Forero, Carlos, additional, Linfert, Douglas, additional, Lora, Henry, additional, Lurie, Alexander, additional, Maddukuri, Geetha, additional, Magno, Alexander, additional, Maletz, Louis, additional, Mandayam, Sreedhar, additional, Markell, Mariana, additional, Mayfield, Ronald, additional, Mbogua, Caroline, additional, McMullen, Dierdre, additional, Meisner, Carl, additional, Minton, Stephen, additional, Mocherla, Bharat, additional, Mohandas, Rajesh, additional, Montero, Manuel, additional, Moustafa, Moustafa, additional, Nadkarni, Salil, additional, Nakhle, Samer, additional, Navarro, Jesus, additional, Neyra, Nilda, additional, Nica, Romanita, additional, Nicol, Philip, additional, Norwood, Paul, additional, Numrungroad, Visal, additional, O'Donovan, Richard, additional, Odugbesan, A., additional, Paoli-Bruno, Jorge, additional, Parikh, Samir, additional, Patel, Rakesh, additional, Peixoto, Aldo, additional, Pergola, Pablo, additional, Perlman, Alan, additional, Pettis, Karlton, additional, Pisoni, Roberto, additional, Ponduchi, Mirela, additional, Posada, Jorge, additional, Prabhakar, Sharma, additional, Radhakrishnan, Jai, additional, Rahman, Mahboob, additional, Raina, Rupesh, additional, Rastogi, Anjay, additional, Reisin, Efrain, additional, Rendell, Marc, additional, Robertson, David, additional, Rocco, Michael, additional, Romeu, Hugo, additional, Rosas, Sylvia, additional, Rosenfeld, Jack, additional, Ross, Dennis, additional, Rothman, Jeffrey, additional, Rudolph, Lance, additional, Ruhullah, Yusuf, additional, Ruoff, Gary, additional, Ryu, Jeffrey, additional, Sahani, Mandeep, additional, Sam, Ramin, additional, Samuels, Garfield, additional, Sanchez, William, additional, Santos, Vladimir, additional, Satko, Scott, additional, Saxena, Sanjeev, additional, Scott, David, additional, Seco, Gilberto, additional, Seek, Melvin, additional, Serota, Harvey, additional, Shafi, Tariq, additional, Shahid, Nauman, additional, Shanik, Michael, additional, Sharma, Santosh, additional, Sinha, Arjun, additional, Smelser, James, additional, Smith, Mark, additional, Soe, Kyaw, additional, Solomon, Richard, additional, Soroka, Eugene, additional, Soufer, Joseph, additional, Spinowitz, Bruce, additional, Spry, Leslie, additional, Suarez, Rosa, additional, Subramanian, Bala, additional, Szerlip, Harold, additional, Tamirisa, Aparna, additional, Thomson, Stephen, additional, Tran, Tuan-Huy, additional, Treger, Richard, additional, Trullenque, Gretel, additional, Turk, Thomas, additional, Umpierrez, Guillermo, additional, Urbach, Daniel, additional, Valdes, Martin, additional, Valika, Shujauddin, additional, Vega, Damaris, additional, Weissman, Peter, additional, Whaley-Connell, Adam, additional, Winston, Jonathan, additional, Wise, Jonathan, additional, Wynne, Alan, additional, Zeig, Steven, additional, Chu, Phuong, additional, Van Hoang, Lam, additional, Khanh, Tran, additional, Thi Phi Nga, Nguyen, additional, Nguyen Son, Pham, additional, and Phuong Tran, Lan, additional
Published: 2022
Full Text: View/download PDF

3. 680-P: Once-Weekly Dulaglutide 3 mg and 4.5 mg Gastrointestinal Tolerability: Post-hoc Analysis of Incidence and Prevalence in Award-11

Author: Juan P. Frias, Enzo Bonora, Heike Jung, Manige Konig, Sohini Raha, David A. Cox, Joanna Van, and Jennifer Peleshok
Subjects: medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Internal medicine, Incidence (epidemiology), Post-hoc analysis, Internal Medicine, Medicine, Once weekly, Dulaglutide, business, Gastrointestinal tolerability, medicine.drug
Published: 2021

4. 651-P: Higher Doses of Dulaglutide Induce Weight Loss in Patients with Type 2 Diabetes (T2D) Regardless of Baseline BMI: Post-hoc Analysis of AWARD-11

Author: Enzo Bonora, Anita Kwan, Juan P. Frias, David A. Cox, Angelyn Bethel, Sohini Raha, and Raleigh E. Malik
Subjects: medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, medicine.disease, Weight loss, Internal medicine, Post-hoc analysis, Internal Medicine, medicine, In patient, Dulaglutide, medicine.symptom, business, Baseline (configuration management), medicine.drug
Published: 2021

5. Efficacy and Safety of Dulaglutide 3.0 mg and 4.5 mg Versus Dulaglutide 1.5 mg in Metformin-Treated Patients With Type 2 Diabetes in a Randomized Controlled Trial (AWARD-11)

Author: Frias, Juan P., primary, Bonora, Enzo, primary, Ruiz, Luis Nevarez, primary, Li, Ying G., primary, Yu, Zhuoxin, primary, Milicevic, Zvonko, primary, Malik, Raleigh, primary, Bethel, M. Angelyn, primary, and Cox, David A., primary
Published: 2021
Full Text: View/download PDF

6. 680-P: Once-Weekly Dulaglutide 3 mg and 4.5 mg Gastrointestinal Tolerability: Post-hoc Analysis of Incidence and Prevalence in Award-11

Author: VAN, JOANNA, primary, FRIAS, JUAN P., additional, BONORA, ENZO, additional, RAHA, SOHINI, additional, JUNG, HEIKE, additional, COX, DAVID, additional, KONIG, MANIGE, additional, and PELESHOK, JENNIFER, additional
Published: 2021
Full Text: View/download PDF

7. 651-P: Higher Doses of Dulaglutide Induce Weight Loss in Patients with Type 2 Diabetes (T2D) Regardless of Baseline BMI: Post-hoc Analysis of AWARD-11

Author: BONORA, ENZO, primary, FRIAS, JUAN P., additional, MALIK, RALEIGH, additional, KWAN, ANITA, additional, RAHA, SOHINI, additional, BETHEL, ANGELYN, additional, and COX, DAVID, additional
Published: 2021
Full Text: View/download PDF

8. 357-OR: Efficacy and Safety of Dulaglutide 3mg and 4.5mg vs. Dulaglutide 1.5mg: 52-Week Results from AWARD-11

Author: Zhuoxin Yu, Zvonko Milicevic, Enzo Bonora, Grace Li, Juan P. Frias, David A. Cox, Angelyn Bethel, Luis Nevárez Ruiz, and Raleigh E. Malik
Subjects: 0301 basic medicine, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Once weekly, 030209 endocrinology & metabolism, Mean age, Rescue medication, Body weight, 03 medical and health sciences, Safety profile, 030104 developmental biology, 0302 clinical medicine, Internal medicine, Internal Medicine, Dose escalation, medicine, Dulaglutide, In patient, business, medicine.drug
Abstract: Dulaglutide (DU) is approved at 2 doses (0.75 and 1.5 mg) for treatment of T2D. In this phase 3 study, once weekly DU 3 mg and 4.5 mg were compared to DU 1.5 mg for efficacy and safety through 52 weeks (wks) (primary endpoint at 36 wks) in patients with inadequately controlled T2D on metformin therapy. Patients were randomized (1:1:1) to once weekly DU 1.5 mg (n=612), DU 3 mg (n=616), and DU 4.5 mg (n=614). All patients were initiated on once weekly DU 0.75 mg for 4 wks, followed by step-wise dose escalation every 4 wks to the randomized dose of 1.5 mg, 3 mg, or 4.5 mg. Efficacy measures were analyzed based on data on-treatment without initiation of rescue medication. Mean age was 57.1 yrs, mean baseline (BL) A1C was 8.6%, and mean BL body weight (BW) was 95.7 kg. DU 1.5 mg, 3 mg and 4.5 mg showed significance (p In conclusion, escalation from DU 1.5 mg to DU 3 mg or 4.5 mg provided clinically relevant, dose-related improvements in glycemic control and body weight with an acceptable safety profile. Disclosure J.P. Frias: Consultant; Self; Eli Lilly and Company, Gilead Sciences, Inc., LifeScan, Inc., Novo Nordisk A/S, Sanofi. Research Support; Self; Allergan plc., AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Bristol-Myers Squibb, Eli Lilly and Company, Intercept Pharmaceuticals, Inc., Madrigal Pharmaceuticals, Inc., Merck & Co., Inc., Novo Nordisk A/S, Pfizer Inc., Sanofi. Speaker’s Bureau; Self; Merck & Co., Inc., Sanofi. E. Bonora: Advisory Panel; Self; Lilly Diabetes, Novartis AG, Sanofi. Speaker’s Bureau; Self; Abbott, Lilly Diabetes, Novo Nordisk A/S, Sanofi. L.A. Nevarez Ruiz: None. G. Li: Employee; Self; Eli Lilly and Company. Z. Yu: None. Z. Milicevic: Employee; Self; Eli Lilly and Company. R. Malik: Employee; Self; Eli Lilly and Company. Stock/Shareholder; Self; Eli Lilly and Company. A. Bethel: Employee; Self; Eli Lilly and Company. D. Cox: Employee; Self; Eli Lilly and Company.
Published: 2020

9. 1468-P: Assessment of Strategies for Identifying Undiagnosed Diabetes Cases in the General Population

Author: Enzo Bonora and Marco Dauriz
Subjects: medicine.medical_specialty, education.field_of_study, business.industry, Endocrinology, Diabetes and Metabolism, Population, Pharmacy, medicine.disease, Northern italy, Poor adherence, Diabetes mellitus, Internal medicine, Internal Medicine, Medicine, Christian ministry, Undiagnosed diabetes, business, education, Public awareness
Abstract: The rising tide of diabetes (DM) calls for strategies applicable at large scale to anticipate diagnosis at the earliest disease stages. However, no conclusive evidence exists on the most effective DM screening program. We tested whether random capillary blood glucose (RCBG), a validated DM risk questionnaire (FINDRISC), or both, may be applied as universal screening strategy in a 4-year (2015-18) multi-center study involving all individuals presenting to the information desks during the World Diabetes Day and similar initiatives in two metropolitan areas of Northern Italy. In case of high FINDRISC scores (>14 points) and/or RCGB levels suggestive for DM (≥200 mg/dL within 2h after last meal/sugar drink;≥150 mg/dL within 2-5h; ≥125 mg/dL, >5h), people were invited to the Diabetes Center (DC) for laboratory confirmation by fasting plasma glucose and A1c. The FINDRISC was also advertised on newspapers and flyers in squares, hospitals and pharmacies of both cities. Overall, 62,827 flyers were distributed and ∼400.000 inhabitants were exposed to the advertisements. Eventually, 154 individuals reporting high FINDRISC scores presented for a laboratory check and diagnosis was confirmed in 18 (11.7%). Among 8,563 individuals undergoing RCBG, 341 (4%) had glucose levels suggestive for DM; 86 had a laboratory check and DM was confirmed in 36 (41.9%). In addition to RCBG, 3,351 subjects also completed the FINDRISC and 480 (14.3%) reported high scores. Of them, 397 (82.7%) presented to the DC and 40 (10.1%) had diagnosis confirmed. In 30 individuals, both FINDRISC and RCBG were suggestive for DM and diagnosis was confirmed in 17/27 subjects eventually presented to the DC (63.0%). These data suggest that RCBG outperforms FINDRISC to identify unknown DM. The simultaneous presence of FINDRISC and RCBG suggestive for DM appears even more effective. Poor adherence to laboratory check in high-risk cases calls for initiatives to raise public awareness on the deleterious concequences of untreated DM. Disclosure M. Dauriz: None. E. Bonora: Advisory Panel; Self; Lilly Diabetes, Novartis AG, Sanofi. Speaker’s Bureau; Self; Abbott, Lilly Diabetes, Novo Nordisk A/S, Sanofi. Funding Italian Ministry of Health (RF-2011-02350193)
Published: 2020

10. variability as an independent correlate of nephropathy, but not retinopathy, in patients with type 2 diabetes: the Renal Insufficiency and Cardiovascular Events (RIACE) Italian Multicenter Study

Author: Penno, Giuseppe, Solini, Anna, Bonora, Enzo, Fondelli, Cecilia, Orsi, Emanuela, Zerbini, Gianpaolo, Morano, Susanna, Cavalot, Franco, Lamacchia, Olga, Laviola, Luigi, Nicolucci, Antonio, and Pugliese, Giuseppe
Subjects: Diabetic retinopathy -- Complications and side effects -- Research -- Care and treatment, Chronic kidney failure -- Complications and side effects -- Research -- Care and treatment, Type 2 diabetes -- Complications and side effects -- Research -- Care and treatment, Health
Abstract: OBJECTIVE--To examine the association of hemoglobin (Hb) [A.sub.1c] variability with microvascular complications in the large cohort of subjects with type 2 diabetes from the Renal Insufficiency And Cardiovascular Events (RIACE) [...]
Published: 2013
Full Text: View/download PDF

11. Comparison of two creatinine-based estimating equations in predicting all-cause and cardiovascular mortality in patients with type 2 diabetes

Author: Targher, Giovanni, Zoppini, Giacomo, Mantovani, William, Chonchol, Michel, Negri, Carlo, Stoico, Vincenzo, Mantovani, Alessandro, De Santi, Francesca, and Bonora, Enzo
Subjects: Chronic kidney failure -- Prognosis -- Research -- Patient outcomes -- Analysis, Mortality -- Analysis, Diabetes -- Research, Type 2 diabetes -- Prognosis -- Research -- Patient outcomes -- Analysis, Health
Abstract: OBJECTIVE--To compare the performance of two glomerular filtration rate (GFR)-estimating equations in predicting the risk of all-cause and cardiovascular mortality in type 2 diabetic patients. RESEARCH DESIGN AND METHODS--We followed [...]
Published: 2012
Full Text: View/download PDF

12. Aortic and mitral annular calcifications are predictive of all-cause and cardiovascular mortality in patients with type 2 diabetes

Author: Rossi, Andrea, Targher, Giovanni, Zoppini, Giacomo, Cicoira, Mariantonietta, Bonapace, Stefano, Negri, Carlo, Stoico, Vincenzo, Faggiano, Pompilio, Vassanelli, Corrado, and Bonora, Enzo
Subjects: Cholesterol, Mortality, Diabetes -- Research, Type 2 diabetes -- Research -- Patient outcomes, Health
Abstract: OBJECTIVE--To examine the association of aortic valve sclerosis (AVS) and mitral annulus calcification (MAC) with all-cause and cardiovascular mortality in type 2 diabetic individuals. RESEARCH DESIGN AND METHODS--We retrospectively analyzed [...]
Published: 2012
Full Text: View/download PDF

13. Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study)

Author: Bacchi, Elisabetta, Negri, Carlo, Zanolin, Maria Elisabetta, Milanese, Chiara, Faccioli, Niccolo, Trombetta, Maddalena, Zoppini, Giacomo, Cevese, Antonio, Bonadonna, Riccardo C., Schena, Federico, Bonora, Enzo, Lanza, Massimo, and Moghetti, Paolo
Subjects: Cholesterol -- Physiological aspects, Medical research -- Physiological aspects, Medicine, Experimental -- Physiological aspects, Dextrose -- Physiological aspects, Diabetes -- Research -- Physiological aspects, Glucose -- Physiological aspects, Weight training -- Physiological aspects, Type 2 diabetes -- Research -- Physiological aspects, Health
Abstract: OBJECTIVE--TO assess differences between the effects of aerobic and resistance training on [HbA.sub.1c] (primary outcome) and several metabolic risk factors in subjects with type 2 diabetes, and to identify predictors [...]
Published: 2012
Full Text: View/download PDF

14. Diverging association of reduced glomerular filtration rate and albuminuria with coronary and noncoronary events in patients with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study

Author: Solini, Anna, Penno, Giuseppe, Bonora, Enzo, Fondelli, Cecilia, Orsi, Emanuela, Arosio, Maura, Trevisan, Roberto, Vedovato, Monica, Cignarelli, Mauro, Andreozzi, Francesco, Nicolucci, Antonio, and Pugliese, Giuseppe
Subjects: Cardiovascular diseases -- Risk factors -- Research, Glomerular filtration rate -- Usage, Albuminuria -- Physiological aspects -- Research, Type 2 diabetes -- Development and progression -- Care and treatment -- Research, Health
Abstract: OBJECTIVE--Although a reduced estimated glomerular filtration rate (eGFR) was shown to be a powerful independent predictor of cardiovascular disease (CVD), other studies suggested that it confers a much lower risk [...]
Published: 2012
Full Text: View/download PDF

15. Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function

Author: Zoppini, Giacomo, Targher, Giovanni, Chonchol, Michel, Ortalda, Vittorio, Abaterusso, Cataldo, Pichiri, Isabella, Negri, Carlo, and Bonora, Enzo
Subjects: Uric acid, Chronic kidney failure -- Research, Diabetes -- Research, Type 2 diabetes -- Research, Diabetics, Health
Abstract: OBJECTIVE--Recent studies have suggested an association between hyperuricemia and adverse renal outcomes in nondiabetic populations. Data on the relationship between hyperuricemia and the risk of incident chronic kidney disease (CKD) [...]
Published: 2012
Full Text: View/download PDF

16. The Toll of Lockdown Against COVID-19 on Diabetes Outpatient Care: Analysis From an Outbreak Area in Northeast Italy

Author: Bonora, Benedetta Maria, primary, Morieri, Mario Luca, additional, Avogaro, Angelo, additional, and Fadini, Gian Paolo, additional
Published: 2020
Full Text: View/download PDF

17. 357-OR: Efficacy and Safety of Dulaglutide 3mg and 4.5mg vs. Dulaglutide 1.5mg: 52-Week Results from AWARD-11

Author: FRIAS, JUAN P., primary, BONORA, ENZO, additional, NEVAREZ RUIZ, LUIS A., additional, LI, GRACE, additional, YU, ZHUOXIN, additional, MILICEVIC, ZVONKO, additional, MALIK, RALEIGH, additional, BETHEL, ANGELYN, additional, and COX, DAVID, additional
Published: 2020
Full Text: View/download PDF

18. The pros and cons of diagnosing diabetes with A1C

Author: Bonora, Enzo and Tuomilehto, Jaakko
Subjects: Diabetes -- Diagnosis -- Research, Glycosylated hemoglobin -- Physiological aspects -- Research, Practice guidelines (Medicine) -- Usage, Health
Abstract: An International Expert Committee was convened in 2008 by the American Diabetes Association (ADA), the European Association for the Study of Diabetes, and the International Diabetes Federation to consider the [...]
Published: 2011
Full Text: View/download PDF

19. Variants of GCKR affect both β-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study 2

Author: Bonetti, Sara, Trombetta, Maddalena, Boselli, Maria Linda, Turrini, Fabiola, Malerba, Giovanni, Trabetti, Elisabetta, Pignatti, Pier Franco, Bonora, Enzo, and Bonadonna, Riccardo C.
Subjects: Isoenzymes -- Analysis -- Research -- Genetic aspects, Genomics -- Analysis -- Genetic aspects -- Research, Dextrose -- Analysis -- Research -- Genetic aspects, Chronic kidney failure -- Analysis -- Genetic aspects -- Research -- Care and treatment, Diabetes -- Research, Pancreatic beta cells -- Analysis -- Research, Glucose -- Analysis -- Research -- Genetic aspects, Type 2 diabetes -- Analysis -- Genetic aspects -- Research -- Care and treatment, Blood proteins -- Analysis -- Genetic aspects -- Research, Health
Abstract: OBJECTIVE--In genome-wide association studies, performed mostly in nondiabetic individuals, genetic variability of glucokinase regulatory protein (GCKR) affects type 2 diabetes-related phenotypes, kidney function, and risk of chronic kidney disease (CKD). [...]
Published: 2011
Full Text: View/download PDF

20. Epidemiology/Genetics

Author: Enzo Bonora, D. Travia, Corinna Brangani, Riccardo C. Bonadonna, Maria Linda Boselli, Marco Dauriz, Vincenzo Stoico, Isabella Pichiri, Maddalena Trombetta, Lorenza Santi, Vittorio Cacciatori, and Carlo Negri
Subjects: medicine.medical_specialty, Beta-cell dysfunction, business.industry, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Newly diagnosed, medicine.disease, Gastroenterology, Insulin resistance, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, business
Published: 2017

21. Elevated serum uric acid concentrations independently predict cardiovascular mortality in type 2 diabetic patients

Author: Zoppini, Giacomo, Targher, Giovanni, Negri, Carlo, Stoico, Vincenzo, Perrone, Fabrizia, Muggeo, Michele, and Bonora, Enzo
Subjects: Uric acid -- Research, Diabetes -- Research, Type 2 diabetes -- Research -- Risk factors -- Patient outcomes -- Prognosis, Diabetics -- Patient outcomes -- Prognosis, Health, Diseases, Research, Risk factors, Prognosis, Patient outcomes
Abstract: OBJECTIVE--There is limited information on whether increased serum uric acid levels are independently associated with cardiovascular mortality in type 2 diabetes. We assessed the predictive role of serum uric acid [...]
Published: 2009

22. 442-P: Excess Burden of Adverse In-Hospital Outcomes in Patients with Diabetes Hospitalized for Stroke

Author: Elisabetta Rinaldi, Chiara Bovo, Enzo Bonora, Stefano Tardivo, Tiziano Lucianer, Lorenza Santi, Marco Dauriz, Anna Altomari, and Elena Tregnaghi
Subjects: medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Mortality rate, medicine.disease, University hospital, Hospital outcomes, Quartile, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, In patient, Major complication, business, Stroke
Abstract: Cerebrovascular accidents (CVA) represent a major complication in diabetes (DM). Real-life evidence as to whether modern management of CVA and DM have softened this relationship is currently limited. We assessed the prevalence of DM, previously known or newly-diagnosed, in all patients (N=542, males 51.5%) admitted for CVA at the Stroke Unit (SU) of Verona University Hospital from 1/1/2015 to 12/31/2016. DM was ascertained by previous diagnosis, glucose-lowering therapy at admission/discharge or admittance plasma glucose (PG) ≥11.1 mmol/L. Prevalence of DM was 21.03% (78.1% known-DM; 21.9% new-DM). In-hospital death rate was 10.5%. Compared to non-DM, patients with DM showed an increased risk of death (15.8 vs. 9.1%; OR 1.87 95% CI, 1.03-3.41) and complications (48.2 vs. 33.3%; 1.87, 1.22-2.86) with similar duration of hospitalization (mean±SEM, 9.14±1.06 vs. 8.80±0.39 days, p=0.72). All deaths occurred in the SU. The “survivors” with DM transferred to non-intensive ward had an out-of-SU hospital stay twice as longer than non-DM (2.32±1.02 vs. 0.98±0.19 days, p=0.038). After multivariable adjustment, DM remained predictor of complications (adj-OR 1.87, 1.22-2.86) but not mortality (1.79, 0.92-3.46). Patients in the highest PG quartile (≥6.55 mmol/L) displayed the highest risk of death (7.89, 2.73-22.79; PG In conclusion, these data highlight that DM frequently occurs in patients admitted for CVA and adds an excess burden of adverse clinical outcomes that urgently calls for strategies to anticipate DM diagnosis in high-risk individuals. Disclosure M. Dauriz: None. E. Tregnaghi: None. L. Santi: None. T. Lucianer: None. A. Altomari: None. E. Rinaldi: None. S. Tardivo: None. C. Bovo: None. E. Bonora: None.
Published: 2019

23. 1502-P: Novel Subgroups of Type 2 Diabetes at Diagnosis in a Southern European Cohort

Author: Maria Linda Boselli, Chiara Zusi, Maddalena Trombetta, Marco Dauriz, Enzo Bonora, and Riccardo C. Bonadonna
Subjects: medicine.medical_specialty, Diabetes risk, business.industry, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Beta-cell Function, Type 2 diabetes, medicine.disease, Insulin resistance, Internal medicine, Diabetes mellitus, Cohort, Internal Medicine, medicine, Christian ministry, business
Abstract: In 739 GADA-negative patients of the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) we investigated whether the 4 (severe insulin deficient: SIDD; severe insulin resistant: SIRD; mild obese: MOD; mild age related: MARD) novel subgroups (1) of type 2 diabetes (T2D) were identifiable at diagnosis. Data-driven 4-means cluster analysis of 4 variables [age, BMI, HOMA2 beta cell function (BCF) and insulin resistance] was run as in (1). Two clusters were consistent with SIDD and MARD; the others were labeled obese insulin resistant (OIRD), likely encompassing MOD and SIRD, and early onset diabetes (EOD) (Table). Among 8 diabetes risk alleles tested in (1), HHEX/IDE (rs1111875) and TSPAN8 (rs7961581) had highest prevalence in OIRD (p References 1. PMID 29503172 Disclosure R.C. Bonadonna: Advisory Panel; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Merck Sharp & Dohme Corp., Sanofi-Aventis. Speaker's Bureau; Self; Eli Lilly and Company, Sanofi-Aventis. M. Trombetta: None. C. Zusi: None. M. Dauriz: None. M. Boselli: None. E. Bonora: None. Funding Italian Ministry of Education, Universities and Research; Italian Scientific Research Programs of Relevant National Interest (2015373Z39_004)
Published: 2019

24. Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in Caucasian subjects from the general population: the Bruneck Study

Author: Bonora, Enzo, Kiechl, Stefan, Willeit, Johann, Oberhollenzer, Friedrich, Egger, Georg, Meigs, James B., Bonadonna, Riccardo C., and Muggeo, Michele
Subjects: Insulin resistance -- Risk factors, Cardiovascular diseases -- Risk factors, Health, Risk factors
Abstract: OBJECTIVE--The purpose of this study was to evaluate whether insulin resistance is associated to cardiovascular disease (CVD) and to understand whether this association can be explained by traditional and novel [...]
Published: 2007

25. Population-based incidence rates and risk factors for type 2 diabetes in white individuals: the Bruneck Study

Author: Bonora, Enzo, Kiechl, Stefan, Willeit, Johann, Oberhollenzer, Friedrich, Egger, Georg, Meigs, James B., Bonadonna Riccardo C., and Muggeo, Michele
Subjects: Diabetes -- Care and treatment, Diabetes -- Research, Type 2 diabetes -- Care and treatment, Type 2 diabetes -- Research, Health
Abstract: Incidence rates and risk factors for type 2 diabetes in low-risk populations are not well documented. We investigated these in white individuals who were aged 40-79 years and from the population of Bruneck, Italy. Of an age- and sex-stratified random sample of 1,000 individuals who were identified in 1990, 919 underwent an oral glucose tolerance test (OGTT) and an assessment of physiological risk factors for diabetes, including insulin resistance (homeostasis model assessment, HOMA-IR), and postchallenge insulin response (Sluiter's Index). Diabetes at baseline by fasting or 2-h OGTT plasma glucose (World Health Organization criteria, n = 82) was excluded, leaving 837 individuals who were followed for 10 years. Incident cases of diabetes were ascertained by confirmed diabetes treatment or a fasting glucose [greater than or equal to] 7.0 mmol/l. At follow-up, 64 individuals had developed diabetes, corresponding to a population-standardized incidence rate of 7.6 per 1,000 person-years. Sex- and age-adjusted incidence rates were elevated 11-fold in individuals with impaired fasting glucose at baseline, 4-fold in those with impaired glucose tolerance, 3-fold in overweight individuals, 10-fold in obese individuals, and ~2-fold in individuals with dyslipidemia or hypertension. Incidence rates increased with increasing HOMA-IR and decreasing Sluiter's Index. As compared with normal insulin sensitivity and normal insulin response, individuals with low insulin sensitivity and low insulin response had a sevenfold higher risk of diabetes. Baseline impaired fasting glucose, BMI, HOMA-IR, and Sluiter's Index were the only independent predictors of incident diabetes in multivariate analyses. We conclude that ~1% of European white individuals aged 40-79 years develop type 2 diabetes annually and that 'subdiabetic' hyperglycemia, obesity, insulin resistance, and impaired insulin response to glucose are independent predictors of diabetes., Type 2 diabetes, by far the most common form of diabetes, is increasing at an alarming rate all over the world. Current projections estimate that the absolute number of cases [...]
Published: 2004

26. Mortality from site-specific malignancies in type 2 diabetic patients from Verona. (Epidemiology/Health Services/Psychosocial Research: Original Article)

Author: Verlato, Giuseppe, Zoppini, Giacomo, Bonora, Enzo, and Muggeo, Michele
Subjects: Mortality -- Italy, Cancer -- Patient outcomes -- Complications and side effects -- Health aspects, Diabetics -- Health aspects -- Patient outcomes, Type 2 diabetes -- Complications and side effects -- Patient outcomes -- Health aspects, Health, Complications and side effects, Patient outcomes, Health aspects
Abstract: OBJECTIVE -- The aim of the present work was to compare mortality from site-specific malignancies in type 2 diabetic patients with those in the general population. RESEARCH DESIGN AND METHODS [...]
Published: 2003

27. Carotid atherosclerosis and coronary heart disease in the metabolic syndrome: prospective data from the Bruneck Study. (Pathophysiology/Complications: Original Article)

Author: Bonora, Enzo, Kiechl, Stefan, Willeit, Johann, Oberhollenzer, Friedrich, Egger, Georg, Bonadonna, Riccardo C., and Muggeo, Michele
Subjects: Coronary heart disease -- Care and treatment -- Complications and side effects, Metabolic syndrome X -- Complications and side effects -- Care and treatment, Carotid artery diseases -- Care and treatment -- Complications and side effects, Atherosclerosis -- Care and treatment -- Complications and side effects, Health, Care and treatment, Complications and side effects
Abstract: OBJECTIVE--The present study aimed at prospectively evaluating carotid atherosclerosis and coronary heart disease (CHD) in subjects with the metabolic syndrome. RESEARCH DESIGN AND METHODS--Within a prospective population-based survey examining 888 [...]
Published: 2003

28. Altered homeostatic adaptation of first- and second-phase β-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess β-cell function. (Pathophysiology)

Author: Bonadonna, Riccardo C., Stumvoll, Michael, Fritsche, Andreas, Muggeo, Michele, Haring, Hans, Bonora, Enzo, and van Haeften, Timon W.
Subjects: Diabetes -- Research, Pancreatic beta cells -- Physiological aspects -- Statistics -- Reports, Type 2 diabetes -- Physiological aspects -- Statistics -- Reports, Health, Statistics, Physiological aspects, Reports
Abstract: We adapted a minimal model to assess β-cell function during a hyperglycemic glucose clamp and to uncover peculiar aspects of the relationship among β-cell function, plasma glucose, and insulin sensitivity (IS) in offspring of Caucasian patients with type 2 diabetes (OfT2D). We pooled two data sets of OfT2D (n = 69) and control subjects (n = 45) with normal glucose regulation. Plasma C-peptide was measured during a hyperglycemic clamp (~10 mmol/l) to quantify model-based first-phase secretion and glucose sensitivity of second-phase secretion (β). IS was quantified during the hyperglycemic clamp. In the pooled data, first-phase secretion was linearly and negatively related to fasting plasma glucose, but not IS; OfT2D lay on a distinct line shifted to the left of the control subjects. In contrast, β was negatively related to IS, and OfT2D lay on a distinct line shifted more and more to the left of the control subjects, as IS was worse. Thus, in OfT2D lower β-cell adaptive responses exist between ambient glycemia and first-phase insulin secretion and between IS and second-phase secretion. Under conditions leading to decreased insulin sensitivity, these disturbed relationships may lead to progression to diabetes in OfT2D., Type 2 diabetes is characterized by defects in both insulin secretion and insulin action (1). Both factors are important in the pathogenesis of the disease and both are influenced by [...]
Published: 2003

29. HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the verona diabetes complications study. (Epidemiology/Health Services/Psychosocial Research)

Author: Bonora, Enzo, Formentini, Gianni, Calcaterra, Francesco, Lombardi, Simonetta, Marini, Franco, Zenari, Luciano, Saggiani, Francesca, Poli, Maurizio, Perbellini, Sandro, Raffaelli, Andrea, Cacciatori, Vittorio, Santi, Lorenza, Targher, Giovanni, Bonadonna, Riccardo, and Muggeo, Michele
Subjects: Cardiovascular research -- Health aspects, Diabetes -- Research, Insulin resistance -- Health aspects -- Risk factors, Cardiovascular diseases -- Risk factors, Health, Risk factors, Health aspects
Abstract: OBJECTIVE -- To evaluate whether homeostasis model assessment--estimated insulin resistance (HOMA-IR) is an independent predictor of cardiovascular disease (CVD) in type 2 diabetes. RESEARCH DESIGN AND METHODS -- Conventional CVD [...]
Published: 2002

30. Nonalcoholic Fatty Liver Disease Is Associated With Ventricular Arrhythmias in Patients With Type 2 Diabetes Referred for Clinically Indicated 24-Hour Holter Monitoring

Author: Giovanni Targher, Isabella Pichiri, Stefano Bonapace, Giacomo Zoppini, Matteo Pernigo, Giovanni Morani, Antonio Rigamonti, Riccardo Rigolon, Filippo Valbusa, Bruna Bolzan, Alessandro Mantovani, Corinna Bergamini, Francesco Violi, Enzo Bonora, Lorenzo Bertolini, and Lorenzo Franceschini
Subjects: Male, Tachycardia, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Ventricular tachycardia, Ventricular Function, Left, Body Mass Index, 0302 clinical medicine, Heart Rate, Non-alcoholic Fatty Liver Disease, Risk Factors, Nonalcoholic fatty liver disease, Prevalence, medicine.diagnostic_test, NAFLD, arrhyhmias, type 2 diabetes, 24-h Holter, Alanine Transaminase, Atrial fibrillation, gamma-Glutamyltransferase, Middle Aged, Cholesterol, Cardiology, Female, 030211 gastroenterology & hepatology, type 2 diabetes, medicine.symptom, medicine.medical_specialty, QT interval, 03 medical and health sciences, NAFLD, Internal medicine, Diabetes mellitus, 24-h Holter, Internal Medicine, medicine, Humans, Aspartate Aminotransferases, Triglycerides, Aged, Retrospective Studies, Advanced and Specialized Nursing, business.industry, medicine.disease, arrhyhmias, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Electrocardiography, Ambulatory, Tachycardia, Ventricular, business, Electrocardiography
Abstract: OBJECTIVE Recent studies have suggested that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of heart rate–corrected QT interval prolongation and atrial fibrillation in patients with type 2 diabetes. Currently, no data exist regarding the relationship between NAFLD and ventricular arrhythmias in this patient population. RESEARCH DESIGN AND METHODS We retrospectively analyzed the data of 330 outpatients with type 2 diabetes without preexisting atrial fibrillation, end-stage renal disease, or known liver diseases who had undergone 24-h Holter monitoring for clinical reasons between 2013 and 2015. Ventricular arrhythmias were defined as the presence of nonsustained ventricular tachycardia (VT), >30 premature ventricular complexes (PVCs) per hour, or both. NAFLD was diagnosed by ultrasonography. RESULTS Compared with patients without NAFLD, those with NAFLD (n = 238, 72%) had a significantly higher prevalence of >30 PVCs/h (19.3% vs. 6.5%, P < 0.005), nonsustained VT (14.7% vs. 4.3%, P < 0.005), or both (27.3% vs. 9.8%, P < 0.001). NAFLD was associated with a 3.5-fold increased risk of ventricular arrhythmias (unadjusted odds ratio [OR] 3.47 [95% CI 1.65–7.30], P < 0.001). This association remained significant even after adjusting for age, sex, BMI, smoking, hypertension, ischemic heart disease, valvular heart disease, chronic kidney disease, chronic obstructive pulmonary disease, serum γ-glutamyltransferase levels, medication use, and left ventricular ejection fraction (adjusted OR 3.01 [95% CI 1.26–7.17], P = 0.013). CONCLUSIONS This is the first observational study to show that NAFLD is independently associated with an increased risk of prevalent ventricular arrhythmias in patients with type 2 diabetes.
Published: 2016

31. Plasma Glucose Levels Throughout the Day and Hb[A.sub.1c] Interrelationships in Type 2 Diabetes: Implications for treatment and monitoring of metabolic control. (Clinical Care/Education/Nutrition)

Author: Bonora, Enzo, Calcaterra, Francesco, Lombardi, Simonetta, Bonfante, Nicoletta, Formentini, Gianni, Bonadonna, Riccardo C., and Muggeo, Michele
Subjects: Metabolic regulation -- Physiological aspects, Diabetes -- Research, Type 2 diabetes -- Physiological aspects, Health, Physiological aspects
Abstract: OBJECTIVE -- To evaluate the extent of plasma glucose excursions with meals, the relations between plasma glucose levels at different times of the day, and the relations between the latter [...]
Published: 2001

32. Relation between soluble adhesion molecules and insulin sensitivity in type 2 diabetic individuals: Role of adipose tissue

Author: Targher, Giovanni, Bonadonna, Riccardo C., Alberiche, Maria, Zenere, Marina B., Muggeo, Michele, and Bonora, Enzo
Subjects: Diabetes -- Research, Insulin resistance -- Physiological aspects, Type 2 diabetes -- Physiological aspects, Health, Physiological aspects
Abstract: OBJECTIVE -- The purpose of this study was to explore the relation between insulin resistance and plasma levels of soluble adhesion molecules and to examine the effects of acute hyperinsulinemia [...]
Published: 2001

33. Current Impact of Diabetes on In-Hospital Survival and Complication Outcomes in Acute Coronary Syndrome (ACS)

Author: Lucia Drezza, Anna Altomari, Flavio Ribichini, Marco Dauriz, Elisabetta Rinaldi, Enzo Bonora, Lorenza Santi, Stefano Tardivo, and Chiara Bovo
Subjects: medicine.medical_specialty, Acute coronary syndrome, Rehabilitation, business.industry, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Mortality rate, Cardiorespiratory fitness, medicine.disease, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Coronary care unit, In patient, business, Complication
Abstract: Prevalence of diabetes is increasing worldwide and outcomes after ACS are thought to improve. We assessed the prevalence of DM, previously known (known-DM) or newly-diagnosed (new-DM), in all patients (n=1,017, males 66.6%) admitted for ACS at the Intensive Coronary Care Unit of the Verona University Hospital from 1/1/2015 to 12/31/2016. DM was ascertained according to previous diagnosis, glucose-lowering therapy at admission/discharge or random plasma glucose ≥11.1 mmol/L. The association of DM with in-hospital death, infectious/cardiorespiratory complications, duration and costs of hospitalization was tested in all patients and separately in known-DM and new-DM. The prevalence of DM was 27.2% (74.1% known-DM; 25.9% new-DM). In-hospital death rate was 4.72%. Compared to nondiabetic patients, those with DM showed an increased risk of death (7.6 vs. 3.6%; OR 2.17 95% CI, 1.20-3.90) and complications (34.4 vs. 23.9%; OR 1.67, 1.23-2.28), a longer hospital stay (median[IQR], 11 [7-17] vs. 8 [6-13] days), higher hospitalization costs (mean±SD, € 10,033±7,626 vs. 8,513±6,363) and more need of rehabilitation at discharge (10.8 vs. 5.9%); P Disclosure M. Dauriz: None. L. Drezza: None. L. Santi: None. A. Altomari: None. E. Rinaldi: None. S. Tardivo: None. C. Bovo: None. F. Ribichini: None. E. Bonora: None.
Published: 2018

34. Effects of Aerobic and Resistance Training on Circulating Micro-RNA Expression Profile in Subjects with Type 2 Diabetes

Author: Marco Dauriz, Debora Olioso, Paolo Moghetti, Enzo Bonora, Carlo Negri, and Elisabetta Bacchi
Subjects: medicine.medical_specialty, Fatty acid metabolism, business.industry, Endocrinology, Diabetes and Metabolism, Physical exercise, Type 2 diabetes, medicine.disease, chemistry.chemical_compound, Endocrinology, Downregulation and upregulation, chemistry, Internal medicine, microRNA, Internal Medicine, medicine, business, Gene, PI3K/AKT/mTOR pathway, Glycemic
Abstract: Structured exercise programs are of great benefit in order to obtain a proper glycemic control in subjects with type diabetes (T2D). However, whether the metabolic effects of aerobic (AER) and resistance (RES) exercise exert specific changes in the expression profile of circulating miRNAs (c-miRNAs) is still largely unknown. We studied 24 individuals with T2D from the RAED2 Trial (NCT01182948), randomly assigned to AER or RES training protocols (NAER=12; NRES=12). Firstly, the baseline and post-training levels of 179 c-miRNAs were measured by RT-PCR in 6 individuals (NAER=3; NRES=3). Nineteen c-miRNAs exhibited at least 20% fold-change variation from baseline and were thereafter measured in the whole group. Compared to baseline, the expression levels of miR-423-3p, miR-451a and miR-766-3p resulted significantly upregulated after exercise, irrespective of exercise type (type I error rate threshold: 0.0026; 0.05/19 miRNAs). Bioinformatic analysis by miRSystem and Diana Tools revealed that these c-miRNAs targeted genes involved in pathways relevant to fatty acids biosynthesis and metabolic regulation, including LKB1, PI3K, mTOR and IRS signaling pathways. Interestingly, miR-451a and miR-423-3p changes were positively correlated with fat loss after training (rho=0.45 and 0.43, respectively; p In conclusion, physical exercise in individuals with T2D is associated with specific changes of c-miRNAs profile, predominantly clustered along pathways with regulatory significance for fatty acid metabolism. Further investigations are warranted to confirm our findings and to unravel their mechanistic significance. Disclosure D. Olioso: None. M. Dauriz: None. E. Bacchi: None. C. Negri: None. E. Bonora: None. P. Moghetti: None.
Published: 2018

35. 1502-P: Novel Subgroups of Type 2 Diabetes at Diagnosis in a Southern European Cohort

Author: BONADONNA, RICCARDO C., primary, TROMBETTA, MADDALENA, additional, ZUSI, CHIARA, additional, DAURIZ, MARCO, additional, BOSELLI, MARIA LINDA, additional, and BONORA, ENZO, additional
Published: 2019
Full Text: View/download PDF

36. 442-P: Excess Burden of Adverse In-Hospital Outcomes in Patients with Diabetes Hospitalized for Stroke

Author: DAURIZ, MARCO, primary, TREGNAGHI, ELENA, additional, SANTI, LORENZA, additional, LUCIANER, TIZIANO, additional, ALTOMARI, ANNA, additional, RINALDI, ELISABETTA, additional, TARDIVO, STEFANO, additional, BOVO, CHIARA, additional, and BONORA, ENZO, additional
Published: 2019
Full Text: View/download PDF

37. Prevalence of insulin resistance in metabolic disorders: the Bruneck study

Author: Bonora, Enzo, Kiechl, Stefan, Willeit, Johann, Oberhollenzer, Friederich, Egger, Georg, Targher, Giovanni, Alberiche, Maria, Bonadonna, Riccardo C., and Muggeo, Michele
Subjects: Hyperuricemia -- Physiological aspects, Dyslipidemias -- Physiological aspects, Insulin resistance -- Demographic aspects -- Physiological aspects, Hypertension -- Physiological aspects, Health, Physiological aspects, Demographic aspects
Abstract: The prevalence of insulin resistance in the most common metabolic disorders is still an undefined issue. We assessed the prevalence rates of insulin resistance in subjects with impaired glucose tolerance [...]
Published: 1998

38. Prevalence of Cardiovascular Autonomic Neuropathy in a Cohort of Patients With Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS)

Author: Carlo Negri, Lorenza Santi, Vittorio Cacciatori, Riccardo C. Bonadonna, Isabella Pichiri, Corinna Brangani, Marialuisa Gemma, F. Bellavere, Corinna Bergamini, Giacomo Zoppini, Daniele Raimondo, Enzo Bonora, Vincenzo Stoico, Marco Dauriz, Karl Thomaseth, Maddalena Trombetta, and Giovanni Targher
Subjects: Male, Research design, medicine.medical_specialty, Multivariate analysis, Endocrinology, Diabetes and Metabolism, Blood Pressure, Type 2 diabetes, Logistic regression, autonomic neuropathy, cardiovascular reflex tests, diabetes complications, Diabetic Neuropathies, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Triglycerides, Aged, Glycated Hemoglobin, Neurologic Examination, Advanced and Specialized Nursing, business.industry, fungi, Cholesterol, HDL, food and beverages, Middle Aged, medicine.disease, cardiac autonomic neuropathy, Surgery, Early Diagnosis, Hemoglobin A, Autonomic Nervous System Diseases, Diabetes Mellitus, Type 2, Cohort, Female, Epidemiologic Methods, Complication, business, Diabetic Angiopathies
Abstract: OBJECTIVE Cardiovascular autonomic diabetic neuropathy (CAN) is a serious complication of diabetes. No reliable data on the prevalence of CAN among patients with newly diagnosed type 2 diabetes are available. Therefore, the aim of this study was to estimate the prevalence of CAN among patients with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS A cohort of 557 patients with newly diagnosed type 2 diabetes with cardiovascular autonomic test results available was selected. Early and confirmed neuropathy were assessed using a standardized methodology and their prevalences determined. A multivariate logistic regression analysis was modeled to study the factors associated with CAN. RESULTS In the entire cohort, the prevalence of confirmed CAN was 1.8%, whereas that of early CAN was 15.3%. Prevalence did not differ between men and women. In the multivariate analyses BMI results were independently and significantly associated with CAN after adjusting for age, sex, hemoglobin A1c, pulse pressure, triglyceride-to-HDL cholesterol ratio, kidney function parameters, and antihypertensive treatment. CONCLUSIONS CAN could be detected very early in type 2 diabetes. This study may suggest the importance of performing standardized cardiovascular autonomic tests after diagnosis of type 2 diabetes.
Published: 2015

39. Epidemiology/Genetics

Author: Stefano Del Prato, Roberto Miccoli, Lorenza Santi, Riccardo C. Bonadonna, Maria Linda Boselli, Cristina Bianchi, Enzo Bonora, Marco Dauriz, Isabella Pichiri, Maddalena Trombetta, and Corinna Brangani
Subjects: American diabetes association, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, medicine.disease, Insulin resistance, Framingham Heart Study, Internal medicine, Epidemiology, Internal Medicine, Medicine, Genetic risk, business, Cardiovascular mortality, Genetic association
Published: 2015

40. Efficacy and Safety of Dulaglutide 3.0 mg and 4.5 mg Versus Dulaglutide 1.5 mg in Metformin-Treated Patients With Type 2 Diabetes in a Randomized Controlled Trial (AWARD-11).

Author: Frias, Juan P., Bonora, Enzo, Nevarez Ruiz, Luis, Li, Ying G., Yu, Zhuoxin, Milicevic, Zvonko, Malik, Raleigh, Bethel, M. Angelyn, and Cox, David A.
Subjects: *DRUG efficacy, *TYPE 2 diabetes, *RANDOMIZED controlled trials, *TERMINATION of treatment, *BODY weight, *RESEARCH, *COMBINATION drug therapy, *IMMUNOGLOBULINS, *RESEARCH methodology, *HYPOGLYCEMIC agents, *MEDICAL cooperation, *EVALUATION research, *TREATMENT effectiveness, *COMPARATIVE studies, *BLIND experiment, *METFORMIN, *GLUCAGON-like peptides, *STATISTICAL sampling, *RECOMBINANT proteins
Abstract: Objective: To compare efficacy and safety of dulaglutide at doses of 3.0 and 4.5 mg versus 1.5 mg in patients with type 2 diabetes inadequately controlled with metformin.Research Design and Methods: Patients were randomly assigned to once-weekly dulaglutide 1.5 mg, 3.0 mg, or 4.5 mg for 52 weeks. The primary objective was determining superiority of dulaglutide 3.0 mg and/or 4.5 mg over 1.5 mg in HbA1c reduction at 36 weeks. Secondary superiority objectives included change in body weight. Two estimands addressed efficacy objectives: treatment regimen (regardless of treatment discontinuation or rescue medication) and efficacy (on treatment without rescue medication) in all randomly assigned patients.Results: Mean baseline HbA1c and BMI in randomly assigned patients (N = 1,842) was 8.6% (70 mmol/mol) and 34.2 kg/m2, respectively. At 36 weeks, dulaglutide 4.5 mg provided superior HbA1c reductions compared with 1.5 mg (treatment-regimen estimand: -1.77 vs. -1.54% [-19.4 vs. -16.8 mmol/mol], estimated treatment difference [ETD] -0.24% (-2.6 mmol/mol), P < 0.001; efficacy estimand: -1.87 vs. -1.53% [-20.4 vs. -16.7 mmol/mol], ETD -0.34% (-3.7 mmol/mol), P < 0.001). Dulaglutide 3.0 mg was superior to 1.5 mg for reducing HbA1c, using the efficacy estimand (ETD -0.17% [-1.9 mmol/mol]; P = 0.003) but not the treatment-regimen estimand (ETD -0.10% [-1.1 mmol/mol]; P = 0.096). Dulaglutide 4.5 mg was superior to 1.5 mg for weight loss at 36 weeks for both estimands (treatment regimen: -4.6 vs. -3.0 kg, ETD -1.6 kg, P < 0.001; efficacy: -4.7 vs. -3.1 kg, ETD -1.6 kg, P < 0.001). Common adverse events through 36 weeks included nausea (1.5 mg, 13.4%; 3 mg, 15.6%; 4.5 mg, 16.4%) and vomiting (1.5 mg, 5.6%; 3 mg, 8.3%; 4.5 mg, 9.3%).Conclusions: In patients with type 2 diabetes inadequately controlled by metformin, escalation from dulaglutide 1.5 mg to 3.0 mg or 4.5 mg provided clinically relevant, dose-related reductions in HbA1c and body weight with a similar safety profile. [ABSTRACT FROM AUTHOR]
Published: 2021
Full Text: View/download PDF

41. The Toll of Lockdown Against COVID-19 on Diabetes Outpatient Care: Analysis From an Outbreak Area in Northeast Italy.

Author: Bonora, Benedetta Maria, Morieri, Mario Luca, Avogaro, Angelo, and Fadini, Gian Paolo
Subjects: *COVID-19, *STAY-at-home orders, *OUTPATIENT medical care, *MEDICAL care, *DIABETES
Abstract: The article offers information on spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from China, Italy became the second most affected country. Topics include the most residents with symptomatic coronavirus disease 2019 (COVID-19) were admitted to the Padua Hospital, and estimating equation to compare clinical characteristics of patients seen during lockdown with characteristics of those attending the clinic in the same period of 2018–2019.
Published: 2021
Full Text: View/download PDF

42. High-normal [HbA.sub.1c] is a strong predictor of type 2 diabetes in the general population

Author: Bonora, Enzo, Kiechl, Stefan, Mayr, Agnes, Zoppini, Giacomo, Targher, Giovanni, Bonadonna, Riccardo C., and Willeit, Johann
Subjects: Glycosylated hemoglobin, Diabetes -- Research, Type 2 diabetes -- Research, Health, American Diabetes Association
Abstract: OBJECTIVE--Glycosylated hemoglobin ([HbA.sub.1c]) recently has been recommended for the diagnosis of diabetes by the American Diabetes Association, but its value in the prediction of type 2 diabetes is poorly understood. [...]
Published: 2011
Full Text: View/download PDF

43. In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension

Author: Bonora, Enzo, Bonadonna, Riccardo C., Del Prato, Stefano, Gulli, Giovanni, Solini, Anna, Matsuda, Masafumi, and DeFronzo, Ralph A.
Subjects: Obesity -- Physiological aspects -- Complications and side effects, Insulin resistance -- Causes of -- Complications and side effects, Glucose metabolism -- Physiological aspects, Type 2 diabetes -- Complications and side effects, Hypertension -- Complications and side effects, Health, Physiological aspects, Complications and side effects, Causes of
Abstract: This study examined whether the presence of hypertension, an insulin-resistant condition, exacerbates the defect in insulin action observed in obesity and type II diabetes mellitus. Glucose metabolism in the basal [...]
Published: 1993

44. Supervised walking groups to increase physical activity in type 2 diabetic patients

Author: Negri, Carlo, Bacchi, Elisabetta, Morgante, Susanna, Soave, Diego, Marques, Alessandra, Menghini, Elisabetta, Muggeo, Michele, Bonora, Enzo, and Moghetti, Paolo
Subjects: Diabetes -- Research, Hypoglycemic agents, Diabetics -- Care and treatment, Type 2 diabetes -- Care and treatment, Walking, Health
Abstract: OBJECTIVE--To evaluate the impact of an exercise program organized into supervised walking groups in subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS--Fifty-nine diabetic subjects were randomized to a control [...]
Published: 2010
Full Text: View/download PDF

45. Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobese and obese nondiabetic women

Author: Bonora, Enzo, Del Prato, Stefano, Bonadonna, Riccardo C., Gulli, Giovanni, Solini, Ann, Shank, Myron L., Ghiatas, Abraham A., Lancaster, Jack L., Kilcoyne, Raphael F., Alyassin, Abdalmajeid M., and DeFronzo, Ralph A.
Subjects: Women -- Physiological aspects, Obesity -- Physiological aspects, Adipose tissues -- Physiological aspects, Glucose metabolism -- Physiological aspects, Health, Physiological aspects
Abstract: In this study, total body fat content and fat topography were related to glucose metabolism in the basal and insulin-stimulated states in 18 nonobese and 18 obese premenopausal nondiabetic women. [...]
Published: 1992

46. Detection of mutations in insulin receptor gene by denaturing gradient gel electrophoresis

Author: Barbetti, Fabrizio, Gejman, Pablo V., Taylor, Simeon I., Raben, Nina, Cama, Alessandro, Bonora, Enzo, Pizzo, Paolo, Moghetti, Paolo, Muggeo, Michele, and Roth, Jesse
Subjects: Insulin -- Receptors, Gel electrophoresis -- Usage -- Research, Mutation (Biology) -- Research -- Usage, Health, Usage, Research
Abstract: Denauring gradient gel electrophoresis (DGGE) has been used to screen for mutations in the insulin receptor gene. Each of the 22 exons was amplified by the polymerase chain reaction (PCR). For each exon, one of the two PCR primers contained a guanine-cytosine (GC) clamp at its 5' end. The DNA was analyzed by electrophoresis through a polyacrylamide gel containing a gradient of denaturants. Two geometries for the gels were compared; the gradient of denaturants was oriented either parallel or perpendicular to the electric field. The sensitivity of the technique was evaluated by determining whether DGGE succeeded in detecting known mutations and polymorphisms in the insulin receptor gene. With parallel gels, 12 of 16 sequence variants were detected. The use of perpendicular gels increased the sensitivity of detection so that all 16 sequence variants were successfully detected when DNA was analyzed by a combination of perpendicular and parallel gels. Furthermore, DGGE was used to investigate a patient with leprechaunism whose insulin receptor genes had not previously been studied. Two mutant alleles were identified in this patient. The allele inherited from the father had a mutation substituting alanine for Val-28; in the allele inherited from the mother, arginine was substituted for Gly-366. Diabetes 41:408-15,1992, Mutations in the insulin receptor gene have been identified as the cause of disease in patients with several genetic syndromes associated with insulin resistance. The mutations can be classified according [...]
Published: 1992

47. Current Impact of Diabetes on In-Hospital Survival and Complication Outcomes in Acute Coronary Syndrome (ACS)

Author: DAURIZ, MARCO, primary, DREZZA, LUCIA, additional, SANTI, LORENZA, additional, ALTOMARI, ANNA, additional, RINALDI, ELISABETTA, additional, TARDIVO, STEFANO, additional, BOVO, CHIARA, additional, RIBICHINI, FLAVIO, additional, and BONORA, ENZO, additional
Published: 2018
Full Text: View/download PDF

48. Effects of Aerobic and Resistance Training on Circulating Micro-RNA Expression Profile in Subjects with Type 2 Diabetes

Author: OLIOSO, DEBORA, primary, DAURIZ, MARCO, additional, BACCHI, ELISABETTA, additional, NEGRI, CARLO, additional, BONORA, ENZO, additional, and MOGHETTI, PAOLO, additional
Published: 2018
Full Text: View/download PDF

49. Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis

Author: Mantovani, Alessandro, primary, Byrne, Christopher D., additional, Bonora, Enzo, additional, and Targher, Giovanni, additional
Published: 2018
Full Text: View/download PDF

50. HbA1c Variability as an Independent Correlate of Nephropathy, but Not Retinopathy, in Patients With Type 2 Diabetes

Author: Raffaella Buzzetti, Emanuela Orsi, Giuseppe Pugliese, Enzo BONORA, Monia Garofolo, Francesco Giorgino, Susanna Morano, Laura Pucci, Francesco Andreozzi, Marco Giorgio Baroni, Salvatore De Cosmo, Luigi Laviola, and Anna Solini
Subjects: Male, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Renal function, Type 2 diabetes, urologic and male genital diseases, Nephropathy, Interquartile range, Internal medicine, Diabetes mellitus, Prevalence, Internal Medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Renal Insufficiency, Chronic, Pathophysiology/Complications, Original Research, Aged, Glycated Hemoglobin, Advanced and Specialized Nursing, Diabetic Retinopathy, business.industry, nutritional and metabolic diseases, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Endocrinology, Diabetes Mellitus, Type 2, Italy, Female, Microalbuminuria, medicine.symptom, business, Diabetic Angiopathies, Kidney disease
Abstract: OBJECTIVE To examine the association of hemoglobin (Hb) A1c variability with microvascular complications in the large cohort of subjects with type 2 diabetes from the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study. RESEARCH DESIGN AND METHODS Serial (3–5) HbA1c values collected in a 2-year period before enrollment were available from 8,260 subjects from 9 centers (of 15,773 patients from 19 centers). HbA1c variability was measured as the intraindividual SD of 4.52 ± 0.76 values. Diabetic retinopathy (DR) was assessed by dilated funduscopy. Chronic kidney disease (CKD) was defined based on albuminuria, as measured by immunonephelometry or immunoturbidimetry, and estimated glomerular filtration rate (eGFR) was calculated from serum creatinine. RESULTS Median and interquartile range of average HbA1c (HbA1c-MEAN) and HbA1c-SD were 7.57% (6.86–8.38) and 0.46% (0.29–0.74), respectively. The highest prevalence of microalbuminuria, macroalbuminuria, reduced eGFR, albuminuric CKD phenotypes, and advanced DR was observed when both HbA1c parameters were above the median and the lowest when both were below the median. Logistic regression analyses showed that HbA1c-SD adds to HbA1c-MEAN as an independent correlate of microalbuminuria and stages 1–2 CKD and is an independent predictor of macroalbuminuria, reduced eGFR, and stages 3–5 albuminuric CKD, whereas HbA1c-MEAN is not. The opposite was found for DR, whereas neither HbA1c-MEAN nor HbA1c-SD affected nonalbuminuric CKD. CONCLUSIONS In patients with type 2 diabetes, HbA1c variability affects (albuminuric) CKD more than average HbA1c, whereas only the latter parameter affects DR, thus suggesting a variable effect of these measures on microvascular complications.
Published: 2013

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

319 results on '"Bonora"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources