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Your search keyword '"Angiotensin -- Physiological aspects"' showing total 5 results
Start Over Descriptor "Angiotensin -- Physiological aspects" Publisher american diabetes association
5 results on '"Angiotensin -- Physiological aspects"'

1. Valsartan improves β-cell function and insulin sensitivity in subjects with impaired glucose metabolism: a randomized controlled trial

Author

Van Der Zijl, Nynke J., Moors, Chantalle C.M., Goossens, Gijs H., Hermans, Marc M.H., Blaak, Ellen E., and Diamant, Michaela

Subjects
Diabetes therapy -- Physiological aspects, Dextrose -- Physiological aspects, Pancreatic beta cells -- Physiological aspects, Hypoglycemic agents -- Research -- Physiological aspects, Clinical trials -- Physiological aspects, Glucose -- Physiological aspects, Glucose metabolism -- Physiological aspects, Antihypertensive drugs -- Research -- Physiological aspects, Type 2 diabetes -- Research -- Physiological aspects, Angiotensin -- Physiological aspects, Health
Abstract

OBJECTIVE--Recently, the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research Trial demonstrated that treatment with the angiotensin receptor blocker (ARB) valsartan for 5 years resulted in a relative reduction [...]

Published
2011
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2. S100B-RAGE-mediated augmentation of Angiotensin II-induced activation of JAK2 in vascular smooth muscle cells is dependent on PLD2

Author

Shaw, Sean S., Schmidt, Ann Marie, Banes, Amy K., Wang, Xiaodan, Stern, David M., and Marrero, Mario B.

Subjects
Diabetes -- Development and progression -- Physiological aspects, Angiotensin -- Physiological aspects, Health, Physiological aspects, Development and progression
Abstract

Angiotensin II (Ang II), a vasoactive peptide that is also considered a growth factor, has been implicated in both normal and diabetic cellular proliferation. We recently found that activation of janus kinase 2 (JAK2) is essential for the Ang II-induced proliferation of vascular smooth muscle cells (VSMCs) and that high glucose augments Ang II-induced proliferation of VSMCs by increasing signal transduction through activation of JAK2. Here, we demonstrate that S100B, a ligand for the receptor of advanced glycation end products (RAGEs), augmented both Ang II-induced tyrosine phosphorylation of JAK2 and cell proliferation in VSMCs in a receptor-dependent manner. We also found that S100B-RAGE interaction triggered intracellular generation of reactive oxygen species (ROS), VSMC proliferation, and JAK2 tyrosine phosphorylation via activation of phospholipase D (PLD)2. These results provide direct evidence for linkages between PLD2, ROS production, and S100B-RAGE-induced enhancement of Ang II-induced cell proliferation and activation of JAK2 in VSMCs. Diabetes 52:2381-2388, 2003, Nonenzymatic glycoxidation, which ultimately leads to the formation of advanced glycation end products (AGEs), occurs when free amino groups are exposed to aldoses, such as high levels of glucose, and [...]

Published
2003

3. Angiotensin II induces expression of the Tie2 receptor ligand, angiopoietin-2, in bovine retinal endothelial cells

Author

Otani, Atsushi, Takagi, Hitoshi, Oh, Hideyasu, Koyama, Shinji, and Honda, Yoshihito

Subjects
Renin-angiotensin system -- Physiological aspects -- Development and progression, Diabetes -- Development and progression, Angiotensin -- Physiological aspects, Health, Physiological aspects, Development and progression
Abstract

Recent studies have shown that angiopoietins (Angs) and their receptor, Tie2, play a role in vascular integrity and neovascularization. The renin-angiotensin system has been hypothesized to contribute to the development [...]

Published
2001

4. Pressor and subpressor doses of angiotensin II increase insulin sensitivity in NIDDM: dissociation of metabolic and blood pressure effects

Author

Morris, Andrew D., Petrie, John R., Ueda, Shinichiro, Connell, John M.C., Elliott, Henry L., Small, Michael, and Donnelly, Richard

Subjects
Insulin -- Physiological aspects, Type 2 diabetes -- Physiological aspects, Angiotensin -- Physiological aspects, Health, Physiological aspects
Abstract

There is evidence that the renin-angiotensin system may be involved in the metabolic as well as the cardiovascular features of diabetes and that pressor doses of angiotensin II (ANG II) [...]

Published
1994

5. Altered regulation of renin secretion by insulinlike growth factors and angiotensin II in diabetic rats

Author

Jost-Vu, Elke, Horton, Richard, and Antonipillai, Indra

Subjects
Renin -- Physiological aspects, Diabetes -- Physiological aspects, Insulin-like growth factors -- Physiological aspects, Angiotensin -- Physiological aspects, Health, Physiological aspects
Abstract

The etiology of the low renin state in DM is not clear. To assess the role of certain growth and regulatory factors in this process, we studied the effects of [...]

Published
1992

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