1. The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review.
- Author
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Gökmen MR, Cosyns JP, Arlt VM, Stiborová M, Phillips DH, Schmeiser HH, Simmonds MS, Cook HT, Vanherweghem JL, Nortier JL, and Lord GM
- Subjects
- Balkan Nephropathy chemically induced, Balkan Nephropathy diagnosis, Balkan Nephropathy epidemiology, Balkan Nephropathy therapy, Humans, Kidney Diseases diagnosis, Kidney Diseases epidemiology, Kidney Diseases physiopathology, Kidney Diseases therapy, Risk Factors, Urologic Neoplasms chemically induced, Urologic Neoplasms diagnosis, Urologic Neoplasms epidemiology, Urologic Neoplasms physiopathology, Urologic Neoplasms therapy, Aristolochic Acids adverse effects, Kidney Diseases chemically induced, Plant Preparations adverse effects
- Abstract
It has been 20 years since the first description of a rapidly progressive renal disease that is associated with the consumption of Chinese herbs containing aristolochic acid (AA) and is now termed aristolochic acid nephropathy (AAN). Recent data have shown that AA is also the primary causative agent in Balkan endemic nephropathy and associated urothelial cancer. Aristolochic acid nephropathy is associated with a high long-term risk for renal failure and urothelial cancer, and the potential worldwide population exposure is enormous. This evidence-based review of the diagnostic approach to and management of AAN draws on the authors' experience with the largest and longest-studied combined cohort of patients with this condition. It is hoped that a better understanding of the importance of this underrecognized and severe condition will improve epidemiologic, preventive, and therapeutic strategies to reduce the global burden of this disease.
- Published
- 2013
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