1. THE RELATIONSHIP BETWEEN SERUM ACE LEVEL AND HYPERTENSION DRUGS IN PATIENTS WITH SARS-COV-2
- Author
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Īsil Ozkocak, Ali Mücahit Ünal, Ayşegül Karalezli, Esra Yakisik Cakir, Ayse Kaya Kalem, Imran Hasanoglu, and H. Canan Hasanoglu
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,biology ,medicine.diagnostic_test ,medicine.drug_class ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Complete blood count ,Angiotensin-converting enzyme ,macromolecular substances ,Calcium channel blocker ,Chest Infections ,Critical Care and Intensive Care Medicine ,medicine.disease ,Procalcitonin ,Coronary artery disease ,Internal medicine ,medicine ,biology.protein ,Outpatient clinic ,Cardiology and Cardiovascular Medicine ,business ,Beta blocker - Abstract
TOPIC: Chest Infections TYPE: Original Investigations PURPOSE: Angiotensin converting enzyme inhibitors (ACEi) can increase ACE2 in human tissues and increase the adhesion of Sars-CoV-2. In our study, we aimed to investigate the relationship between serum ACE level with antihypertensive drugs (especially ACEi) and clinical severity. METHODS: A total of 200 symptomatic Sars-CoV-2 patients who were hospitalized or diagnosed in an outpatient clinic were included in the study. The patients were divided into 4 groups as mild, moderate, severe and very severe. There were 43 patients in the mild, 54 patients in the moderate, 53 patients in the severe, and 50 patients in the very severe patient group. Later, 200 patients were divided into 2 groups as mild-moderate (n:97) and severe-very severe patient group (n:103). Serum ACE, complete blood count, C-reactive protein (CRP), procalcitonin and biochemical analysis were evaluated. The demographic data, comorbidities, medications and symptoms of the patients were recorded. RESULTS: The mean age of mild, moderate, severe and very severe patients was 50.4±21.51, 57.13±14.81, 64.34±13.02, 74.88±11.18 respectively (p
- Published
- 2021