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Your search keyword '"Vincenzo Pavone"' showing total 15 results
Start Over Author "Vincenzo Pavone" Publisher american chemical society (acs)
15 results on '"Vincenzo Pavone"'

1. Highly Selective Indole Oxidation Catalyzed by a Mn-Containing Artificial Mini-Enzyme

Author

Angela Lombardi, Daniele D'Alonzo, Linda Leone, Flavia Nastri, Vincenzo Pavone, Ornella Maglio, Leone, L., D'Alonzo, D., Maglio, O., Pavone, V., Nastri, F., and Lombardi, A.

Subjects
chemistry.chemical_classification, Indole test, peroxygenase catalyst, General Chemistry, Highly selective, Combinatorial chemistry, Catalysis, Enzyme, indole, chemistry, oxidation reaction, artificial metalloenzyme, metalloporphyrin
Abstract

Indole oxidation represents a real challenge for selectivity because it typically leads to complex mixtures of products even when highly selective enzymes are used. Here, we describe the catalytic potential of an artificial enzyme, Mn-Mimochrome VI*a (Mn-MC6*a), in promoting indole oxidation. This mini-enzyme contains a manganese-deuteroporphyrin active site within a scaffold of two synthetic small peptides covalently linked to porphyrin. Mn-MC6*a promotes the selective oxidation of indole at its C3 position, leading to a 3-oxindole derivative (2-TFE-3-oxindole) with unprecedented product selectivity (86% at pH 8.5) compared to native or artificial heme-enzymes. We also suggest a possible reaction mechanism based on the effect of pH, cosolvent, and indole substitution on the reaction outcome. These studies demonstrate that Mn-MC6*a is an excellent artificial peroxygenase for the production of 3-oxindole-containing compounds as key building blocks for the synthesis of fine chemicals.

Published
2021

2. Bioactive peptides: x-ray and NMR conformational study of [Aib5,6-D-Ala8]cyclolinopeptide A

Author

Ettore Benedetti, Benedetto Di Blasio, Michele Saviano, Filomena Rossi, Giancarlo Zanotti, Carlo Pedone, Teodorico Tancredi, and Vincenzo Pavone

Subjects
chemistry.chemical_classification, Stereochemistry, Hydrogen bond, X-ray, Peptide, General Chemistry, Crystal structure, Nuclear magnetic resonance spectroscopy, Ring (chemistry), Biochemistry, Catalysis, Colloid and Surface Chemistry, chemistry, Cyclolinopeptide A, Orthorhombic crystal system
Abstract

The conformational analysis of [Aib 5,6 -D-Ala 8 ]cyclolinopeptide A, in the solid state and solution, has been carried out by X-ray diffraction and NMR spectroscopy. The structure of the orthorhombic form, obtained from methanol-water mixture [a=29.92 (3) A b=19.85 (3) A, c=9.90 (1) A, space group P2 1 2 1 2 1 Z=4], shows the presence of five in N-H...O=C hydrogen bonds, with formation of one C 17 ring structure, one α-turn (C 13 ), one γ-turn (C 7 ), and two β-turns (C 10 , one of type III and one of type I)

Published
1992

3. Crystal structure of two retro-inverso sweeteners

Author

Benedetto Di Blasio, Vincenzo Pavone, Murray Goodman, Carlo Pedone, William D. Fuller, Dale F. Mierke, and Ettore Benedetti

Subjects
Crystallography, Colloid and Surface Chemistry, Chemistry, General Chemistry, Retro inverso, Crystal structure, Biochemistry, Catalysis
Published
1990

4. Structural versatility of peptides from C.alpha.,.alpha.-dialkylated glycines. An infrared absorption and 1H nuclear magnetic resonance study of homopeptides from 1-aminocyclohexane-1-carboxylic acid1

Author

Claudio Toniolo, Carlo Pedone, Alfonso Bavoso, B. Di Blasio, Gian Maria Bonora, Vincenzo Pavone, Marco Crisma, and Ettore Benedetti

Subjects
Inorganic Chemistry, chemistry.chemical_classification, Nuclear magnetic resonance, Structure modification, Condensation polymer, Polymers and Plastics, Chemistry, Stereochemistry, Organic Chemistry, Materials Chemistry, Alpha (ethology), Infrared spectroscopy, Peptide
Published
1988

5. A long, regular polypeptide 310-helix

Author

Ettore Benedetti, Carlo Pedone, Gian Maria Bonora, B. Di Blasio, Claudio Toniolo, Alfonso Bavoso, and Vincenzo Pavone

Subjects
Polymers and Plastics, Proton, Organic Chemistry, Analytical chemistry, Infrared spectroscopy, Oligomer, Inorganic Chemistry, chemistry.chemical_compound, Crystallography, chemistry, 310 helix, Materials Chemistry, Chemical solution, Thermal stability
Published
1986

6. Solid-State and Solution Conformation of N-tert-Butyloxycarbonyl-L-prolylglycine

Author

Gian Maria Bonora, Manlio Palumbo, Claudio Toniolo, Ettore Benedetti, Vincenzo Pavone, E., Benedetti, Pavone, Vincenzo, C., Toniolo, G. M., Bonora, and M., Palumbo

Subjects
Models, Molecular, Circular dichroism, Proline, Spectrophotometry, Infrared, Polymers and Plastics, Protein Conformation, Glycine, Molecular Conformation, Infrared spectroscopy, Inorganic Chemistry, Protein structure, X-Ray Diffraction, Spectrophotometry, Materials Chemistry, medicine, medicine.diagnostic_test, Chemistry, Circular Dichroism, Organic Chemistry, Peptide Conformation, Folding (chemistry), Crystallography, X-ray crystallography, Thermodynamics, Polar, Peptides
Abstract

The occurrence of the oxy analogue in the trans-II 4 leads to 1 intramolecularly hydrogen-bonded nonhelical peptide conformation, recently proposed for t-BOC-L-Pro-Gly-OH in the solid state on the basis of infrared absorption evidence, has been disproved by x-ray diffraction analysis. This type of folding is also absent in polar solvents. However, in solvents of low polarity the presence of this folded form cannot be excluded.

Published
1977

7. Folded and extended structures of homooligopeptides from .alpha.,.alpha.-dialkylated .alpha.-amino acids. An infrared absorption and proton nuclear magnetic resonance study

Author

Ian N. Lingham, Carlo Pedone, Claudio Toniolo, Benedetto Di Blasio, Ettore Benedetti, Gian Maria Bonora, Vincenzo Pavone, and Paul M. Hardy

Subjects
chemistry.chemical_classification, Colloid and Surface Chemistry, chemistry, Stereochemistry, Proton NMR, Alpha (ethology), Infrared spectroscopy, General Chemistry, Biochemistry, Catalysis, Amino acid
Published
1984

8. Linear oligopeptides. 81. Solid-state and solution conformation of homooligo(.alpha.-aminoisobutyric acids) from tripeptide to pentapeptide: evidence for a 310 helix

Author

Gian Maria Bonora, Claudio Toniolo, B. Di Blasio, Ettore Benedetti, Carlo Pedone, Alfonso Bavoso, Vincenzo Pavone, and Marco Crisma

Subjects
Oligopeptide, Colloid and Surface Chemistry, 310 helix, Chemistry, Stereochemistry, Solid-state, Alpha (ethology), General Chemistry, Tripeptide, Biochemistry, Pentapeptide repeat, Catalysis, Aminoisobutyric acid
Published
1982

9. Bioactive peptides: solid-state and solution conformation of cyclolinopeptide A

Author

Carlo Pedone, Teodorico Tancredi, Benedetto Di Blasio, Piero Andrea Temussi, Giancarlo Zanotti, Filomena Rossi, Vincenzo Pavone, and Ettore Benedetti

Subjects
Colloid and Surface Chemistry, Computational chemistry, Chemistry, Stereochemistry, Cyclolinopeptide A, Solid-state, General Chemistry, Biochemistry, Catalysis
Published
1989

11. Conformation of pleionomers of .alpha.-aminoisobutyric acid

Author

Carlo Pedone, Benedetto Di Blasio, Vincenzo Barone, Gian Maria Bonora, Vincenzo Pavone, Patrizio Grimaldi, Ettore Benedetti, Claudio Toniolo, Alfonso Bavoso, and Francesco Lelj

Subjects
Inorganic Chemistry, chemistry.chemical_compound, Alpha-aminoisobutyric acid, Polymers and Plastics, Biochemistry, Stereochemistry, Chemistry, Organic Chemistry, Materials Chemistry, Oligomer
Published
1985

13. Structural versatility of peptides from C.alpha.,.alpha.-dialkylated glycines. A conformational energy computation and x-ray diffraction study of homopeptides from 1-aminocyclohexane-1-carboxylic acid1

Author

Ettore Benedetti, Vincenzo Barone, B. Di Blasio, Antonello Santini, Carlo Pedone, Claudio Toniolo, Francesco Lelj, Vincenzo Pavone, Marco Crisma, and Gian Maria Bonora

Subjects
chemistry.chemical_classification, Condensation polymer, Polymers and Plastics, Stereochemistry, Chemistry, Organic Chemistry, Alpha (ethology), Peptide, Crystal structure, Inorganic Chemistry, Crystallography, X-ray crystallography, Materials Chemistry, Molecule, Conformational energy
Published
1988

14. Structural versatility of peptides from C.alpha.,.alpha.-dialkylated glycines. A conformational energy computation and x-ray diffraction study of homopeptides from 1-aminocyclohexane-1-carboxylic acid [Erratum to document cited in CA109(7)55221x]

Author

Gian Maria Bonora, Ettore Benedetti, Marco Crisma, B. Di Blasio, Francesco Lelj, Vincenzo Barone, Antonello Santini, Carlo Pedone, Claudio Toniolo, and Vincenzo Pavone

Subjects
Inorganic Chemistry, chemistry.chemical_classification, Crystallography, Polymers and Plastics, chemistry, Stereochemistry, Carboxylic acid, Organic Chemistry, X-ray crystallography, Materials Chemistry, Alpha (ethology), Conformational energy
Published
1989

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