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Your search keyword '"Thorwirth, Sven"' showing total 14 results
Start Over Author "Thorwirth, Sven" Publisher american chemical society (acs)
14 results on '"Thorwirth, Sven"'

3. Spontaneous and Selective Formation of HSNO, a Crucial Intermediate Linking H

Author

Massachusetts Institute of Technology. Department of Chemistry, Nava, Matthew Jordan, Womack, Caroline C., Cummins, Christopher C, Martin-Drumel, Marie-Aline, Lopez, Christopher A., Crabtree, Kyle N., Nguyen, Thanh L., Thorwirth, Sven, Stanton, John F., McCarthy, Michael C., Massachusetts Institute of Technology. Department of Chemistry, Nava, Matthew Jordan, Womack, Caroline C., Cummins, Christopher C, Martin-Drumel, Marie-Aline, Lopez, Christopher A., Crabtree, Kyle N., Nguyen, Thanh L., Thorwirth, Sven, Stanton, John F., and McCarthy, Michael C.

Abstract

Thionitrous acid (HSNO), a potential key intermediate in biological signaling pathways, has been proposed to link NO and H[superscript 2]S biochemistries, but its existence and stability in vivo remain controversial. We establish that HSNO is spontaneously formed in high concentration when NO and H[subscript 2]S gases are mixed at room temperature in the presence of metallic surfaces. Our measurements reveal that HSNO is formed by the reaction H[superscript 2]S + N[subscript 2]O[subscript 3] → HSNO + HNO[subscript 2], where N[superscript 2]O[superscript 3] is a product of NO disproportionation. These studies also suggest that further reaction of HSNO with H[subscript 2]S may form HNO and HSSH. The length of the S–N bond has been derived to high precision and is found to be unusually long: 1.84 Å, the longest S–N bond reported to date for an R-SNO compound. The present structural and, particularly, reactivity investigations of this elusive molecule provide a firm foundation to better understand its potential physiological chemistry and propensity to undergo S–N bond cleavage in vivo.

Published
2018

4. Spontaneous and Selective Formation of HSNO, a Crucial Intermediate Linking H₂S and Nitroso Chemistries

Author

Massachusetts Institute of Technology. Department of Chemistry, Nava, Matthew Jordan, Womack, Caroline C., Cummins, Christopher C, Martin-Drumel, Marie-Aline, Lopez, Christopher A., Crabtree, Kyle N., Nguyen, Thanh L., Thorwirth, Sven, Stanton, John F., McCarthy, Michael C., Massachusetts Institute of Technology. Department of Chemistry, Nava, Matthew Jordan, Womack, Caroline C., Cummins, Christopher C, Martin-Drumel, Marie-Aline, Lopez, Christopher A., Crabtree, Kyle N., Nguyen, Thanh L., Thorwirth, Sven, Stanton, John F., and McCarthy, Michael C.

Abstract

Thionitrous acid (HSNO), a potential key intermediate in biological signaling pathways, has been proposed to link NO and H₂S biochemistries, but its existence and stability in vivo remain controversial. We establish that HSNO is spontaneously formed in high concentration when NO and H₂S gases are mixed at room temperature in the presence of metallic surfaces. Our measurements reveal that HSNO is formed by the reaction H₂S + N₂O₃ → HSNO + HNO₂, where N₂O₃ is a product of NO disproportionation. These studies also suggest that further reaction of HSNO with H₂S may form HNO and HSSH. The length of the S-N bond has been derived to high precision and is found to be unusually long: 1.84 Å, the longest S-N bond reported to date for an R-SNO compound. The present structural and, particularly, reactivity investigations of this elusive molecule provide a firm foundation to better understand its potential physiological chemistry and propensity to undergo S-N bond cleavage in vivo., United States. National Aeronautics and Space Administration (Grant NNX13AE59G)

Published
2018

12. High-Resolution Spectroscopy of C3 around 3 μm

Author

Krieg, Jürgen, primary, Lutter, Volker, additional, Endres, Christian P., additional, Keppeler, Imke H., additional, Jensen, Per, additional, Harding, Michael E., additional, Vázquez, Juana, additional, Schlemmer, Stephan, additional, Giesen, Thomas F., additional, and Thorwirth, Sven, additional

Published
2013
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