103 results on '"Portoghese, Philip S."'
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2. FBNTI, a DOR-Selective Antagonist That Allosterically Activates MOR within a MOR–DOR Heteromer
3. Combined Glia Inhibition and Opioid Receptor Agonism Afford Highly Potent Analgesics without Tolerance
4. Heteromer Induction: An Approach to Unique Pharmacology?
5. Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)
6. Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects
7. Bivalent Ligands That Target μ Opioid (MOP) and Cannabinoid1 (CB1) Receptors Are Potent Analgesics Devoid of Tolerance
8. An Immunocytochemical-Derived Correlate for Evaluating the Bridging of Heteromeric Mu-Delta Opioid Protomers by Bivalent Ligands
9. Reduced Antinociception of Opioids in Rats and Mice by Vaccination with Immunogens Containing Oxycodone and Hydrocodone Haptens
10. Clinically Employed Opioid Analgesics Produce Antinociception via μ-δ Opioid Receptor Heteromers in Rhesus Monkeys
11. The δ Opioid Receptor Agonist SNC80 Selectively Activates Heteromeric μ–δ Opioid Receptors
12. Opioid Activity of Spinally Selective Analogues of N-Naphthoyl-β-naltrexamine in HEK-293 Cells and Mice
13. My Farewell to the Journal of Medicinal Chemistry
14. A κ Opioid Pharmacophore Becomes a Spinally Selective κ-δ Agonist When Modified with a Basic Extender Arm
15. Modulation of Cell Surface Expression of Nonactivated Cholecystokinin Receptors Using Bivalent Ligand-Induced Internalization
16. Standard Opioid Agonists Activate Heteromeric Opioid Receptors: Evidence for Morphine and [d-Ala2-MePhe4-Glyol5]Enkephalin as Selective μ−δ Agonists
17. Synthesis and in Vitro Characterization of Radioiodinatable Benzodiazepines Selective for Type 1 and Type 2 Cholecystokinin Receptors
18. Revision of Purity Criteria for Tested Compounds
19. Induced Association of μ Opioid (MOP) and Type 2 Cholecystokinin (CCK2) Receptors by Novel Bivalent Ligands
20. o-Naphthalenedicarboxaldehyde Derivative of 7‘-Aminonaltrindole as a Selective δ-Opioid Receptor Affinity Label
21. The State of the Journal at Its 50th Publication Volume
22. Specific Cross-Linking of Lys233 and Cys235 in the Mu Opioid Receptor by a Reporter Affinity Label
23. A Bivalent Ligand (KDAN-18) Containing δ-Antagonist and κ-Agonist Pharmacophores Bridges δ2 and κ1 Opioid Receptor Phenotypes
24. A Bivalent Ligand (KDN-21) Reveals Spinal δ and κ Opioid Receptors Are Organized as Heterodimers That Give Rise to δ1 and κ2 Phenotypes. Selective Targeting of δ−κ Heterodimers
25. Naphthalene Dicarboxaldehyde as an Electrophilic Fluorogenic Moiety for Affinity Labeling: Application to Opioid Receptor Affinity Labels with Greatly Improved Fluorogenic Properties
26. 2000 Alfred Burger Award Address in Medicinal Chemistry. From Models to Molecules: Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes.
27. Transformation of a κ-Opioid Receptor Antagonist to a κ-Agonist by Transfer of a Guanidinium Group from the 5‘- to 6‘-Position of Naltrindole
28. From Models to Molecules: Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes
29. Covalently Induced Activation of the δ Opioid Receptor by a Fluorogenic Affinity Label, 7‘-(Phthalaldehydecarboxamido)naltrindole (PNTI)
30. Investigation of the Selectivity of Oxymorphone- and Naltrexone-Derived Ligands via Site-Directed Mutagenesis of Opioid Receptors: Exploring the ‘Address' Recognition Locus
31. Web Submission of Letters To Replace Communications
32. Potent and Selective Indolomorphinan Antagonists of the Kappa-Opioid Receptor
33. Reporter Affinity Labels: An o-Phthalaldehyde Derivative of β-Naltrexamine as a Fluorogenic Ligand for Opioid Receptors
34. Binding of Norbinaltorphimine (norBNI) Congeners to Wild-Type and Mutant Mu and Kappa Opioid Receptors: Molecular Recognition Loci for the Pharmacophore and Address Components of Kappa Antagonists
35. Isosteric Replacement of Acidic with Neutral Residues in Extracellular Loop-2 of the κ-Opioid Receptor Does Not Affect Dynorphin A(1−13) Affinity and Function
36. Investigation of Phenolic Bioisosterism in Opiates: 3-Sulfonamido Analogues of Naltrexone and Oxymorphone
37. Molecular Docking Reveals a Novel Binding Site Model for Fentanyl at the μ-Opioid Receptor
38. A Flexible Policy Concerning Purity Criteria for Published Target Compounds
39. Mutational Evidence for a Common κ Antagonist Binding Pocket in the Wild-Type κ and Mutant μ[K303E] Opioid Receptors
40. Conformational Analysis and Automated Receptor Docking of Selective Arylacetamide-Based κ-Opioid Agonists
41. 7-Arylidenenaltrexones as Selective δ1 Opioid Receptor Antagonists
42. Synthesis of 7-Arylmorphinans. Probing the “Address” Requirements for Selectivity at Opioid δ Receptors
43. 14-Desoxy Analogues of Naltrindole and 7-Spiroindanyloxymorphone: The Role of the 14-Hydroxy Group at δ Opioid Receptors
44. Stereospecific Synthesis of Pseudocodeine: [2,3]-Sigmatropic Rearrangement Using Selenium Intermediates
45. Opiate Dienes as Dienophiles in the Diels−Alder Reaction with 1-Cyano-o-quinodimethane
46. Accelerated Electronic Publication
47. 7-Spirobenzocyclohexyl Derivatives of Naltrexone, Oxymorphone, and Hydromorphone as Selective Opioid Receptor Ligands
48. Boron Tribromide-Catalyzed Rearrangement of 7,7-Diphenylhydromorphone to 6,7-Diphenylmorphine: A Novel Conversion of Ketones to Allylic Alcohols
49. Arylacetamide-Derived Fluorescent Probes: Synthesis, Biological Evaluation, and Direct Fluorescent Labeling of κ Opioid Receptors in Mouse Microglial Cells
50. Aspartic Acid Conjugates of 2-(3,4-Dichlorophenyl)-N-methyl-N- [(1S)-1-(3-aminophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: κ Opioid Receptor Agonists with Limited Access to the Central Nervous System
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