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Your search keyword '"Pavlović, Nikola M."' showing total 10 results
Start Over Author "Pavlović, Nikola M." Publisher american chemical society (acs)
10 results on '"Pavlović, Nikola M."'

1. Fabrication of a Simple and Efficient HPLC Reduction Column for Online Conversion of Aristolochic Acids to Aristolactams Prior to Sensitive Fluorescence Detection

Author

Chin, Man-Lung, primary, Au, Chun-Kit, additional, Chan, Chi-Kong, additional, Jin, Long, additional, Živković Stošić, Milena Z., additional, Đorđević Zlatković, Miljana R., additional, Zlatković, Dragan, additional, Pavlović, Nikola M., additional, and Chan, Wan, additional

Published
2023
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3. Fabrication of a Simple and Efficient HPLC Reduction Column for Online Conversion of Aristolochic Acids to Aristolactams Prior to Sensitive Fluorescence Detection

Author

Chin, Man Lung, Au, Chun Kit, Chan, Chi Kong, Jin, Long, Stošić, Živković Milena Z., Zlatković, Đorđević Miljana R., Zlatković, Dragan, Pavlović, Nikola M., Chan, Wan, Chin, Man Lung, Au, Chun Kit, Chan, Chi Kong, Jin, Long, Stošić, Živković Milena Z., Zlatković, Đorđević Miljana R., Zlatković, Dragan, Pavlović, Nikola M., and Chan, Wan

Abstract

Aristolochic acids (AAs) are nephrotoxic and carcinogenic nitrophenanthrene carboxylic acids produced naturally by plants from the Aristolochia and Asarum genera, which have been used extensively as herbal medicines. In addition to consuming AA-containing herbal medicinal products, there is emerging evidence that humans are also exposed to AA through the environment. In 2022, the World Health Organization (WHO) called for global action to remove AA exposure sources and to implement preventative measures against the development of AA-associated cancers. Herein, we report the development of a simple and efficient iron powder-packed reduction column that allows online post-column conversion of the nonfluorescing AA to its corresponding strongly fluorescing aristolactam (AL), facilitating the sensitive and selective detection of AA in herbal medicinal products, food grain, arable soil, or groundwater samples by high-performance liquid chromatography with fluorescence detection. Moreover, AL, a group of naturally occurring derivatives of AA that have demonstrated toxicity to cultured bacteria, human cells, and rats, is monitored and quantified simultaneously with AA in one single run without sacrificing sensitivity. In comparison with existing analytical methods for AA measurement, the newly developed method is not only inexpensive and less laborious, but it also offers improved sensitivity. We believe this novel method will find wide application in identifying the presence of AA in food, herbal medicines, and environmental samples, thus assisting in the identification and removal of AA exposure sources.

Published
2023

5. Analysis of Polycyclic Aromatic Hydrocarbons and Phthalate Esters in Soil and Food Grains from the Balkan Peninsula: Implication on DNA Adduct Formation by Aristolochic Acid I and Balkan Endemic Nephropathy

Author

Guo, Wanlin, primary, Zhang, Jiayin, additional, Sun, Zhihan, additional, Orem, William H., additional, Tatu, Calin A., additional, Radulović, Niko S., additional, Milovanović, Dragan, additional, Pavlović, Nikola M., additional, and Chan, Wan, additional

Published
2021
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9. Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake

Author

Li, Weiwei, primary, Chan, Chi-Kong, additional, Liu, Yushuo, additional, Yao, Jing, additional, Mitić, Branka, additional, Kostić, Emina N., additional, Milosavljević, Biljana, additional, Davinić, Ivana, additional, Orem, William H., additional, Tatu, Calin A., additional, Dedon, Peter C., additional, Pavlović, Nikola M., additional, and Chan, Wan, additional

Published
2018
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