1. Characterization of Phosphopeptide Positional Isomers on the Transcriptional Co-activator TAZ
- Author
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Catherine E. Sykes, Panayiotis O. Vacratsis, and Justin Roberto
- Subjects
Phosphopeptides ,Cytoplasm ,Cellular differentiation ,Regulator ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Structural isomer ,Humans ,Phosphorylation ,Co activator ,Cell Proliferation ,030304 developmental biology ,Cell Nucleus ,0303 health sciences ,Chemistry ,Phosphopeptide ,Cell growth ,Intracellular Signaling Peptides and Proteins ,Cell Differentiation ,Cell biology ,HEK293 Cells ,14-3-3 Proteins ,030220 oncology & carcinogenesis ,Trans-Activators ,Pdz binding motif ,Signal Transduction ,Transcription Factors - Abstract
The transcriptional co-activator with the PDZ binding motif (TAZ) is a critical regulator of numerous cellular processes such as cell differentiation, development, proliferation, and cell growth. Aberrant expression and activity of TAZ are also featured in many human malignancies. A hallmark of TAZ biology is its cytoplasmic retention mediated by 14-3-3 isoforms in response to phosphorylation of Ser
- Published
- 2020
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