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Your search keyword '"Noboru Kubodera"' showing total 2 results
Start Over Author "Noboru Kubodera" Publisher american chemical society (acs)
2 results on '"Noboru Kubodera"'

1. Industrial Synthesis of Maxacalcitol, the Antihyperparathyroidism and Antipsoriatic Vitamin D3 Analogue Exhibiting Low Calcemic Activity

Author

Hitoshi Shimizu, Kazuki Shimizu, Makoto Tanabe, Kaname Tsuzaki, Yasushi Kito, Koji Harada, Toshiro Kozono, Motoki Shimizu, Daisuke Hirasawa, Hideki Tanaka, Hiroyuki Suwa, Mio Kobayashi, Masaharu Kigawa, Mitsutaka Yoshida, Noboru Kubodera, Masahiro Kato, Akira Hiraide, Kaichiro Koyama, Tetsuhiro Mikami, Yoshihide Ichikawa, and Masanori Iguchi

Subjects
Reaction conditions, Vitamin, chemistry.chemical_compound, Chemistry, Yield (chemistry), Organic Chemistry, Organic chemistry, Physical and Theoretical Chemistry
Abstract

Maxacalcitol, the 22-oxa-derivative of 1α,25-dihydroxyvitamin D3 and used currently as an antihyperparathyroidism and antipsoriatic drug, has been synthesized in seven chemical steps from 1α-hydroxydehydroepiandrosterone on the basis of our previously developed route. The present synthesis allows the production of the protected form of the penultimate intermediate in 26% overall yield in a kilogram scale reaction employing neither difficult reaction conditions nor chromatographic purification, having overcome all the difficulties involved in the previous route.

Published
2005
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