Clearly capillary columns containing immobilized cyclodextrin coatings will be useful for a variety of separation methods. Although hardy, they will not completely replace the coated columns for GC separations. This is because the enantioselectivity of the bonded column is somewhat different from many of the coated columns. Also there is a greater variety of coated columns, which means a greater variety of enantiomers and other compounds can be resolved. Finally, for lower temperature GC separations, the performance and enantioselectivity of the coated columns sometimes exceeds that of the bonded-phase columns. However for longevity and performance at high temperatures, with supercritical fluids, or in the presence of solvents, the immobilized cyclodextrin-based stationary phase is not only effective, but often essential. 10 refs., 4 figs., 2 tabs.