1. Unexpected Role of Ru(II) Orbital and Spin Contribution on Photoinduced Ligand Exchange: New Mechanism To Access the Photodynamic Therapy Window
- Author
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Kathlyn F. Al-Afyouni, Curtis E. Moore, Claudia Turro, Jeffrey J. Rack, Judith C. Gallucci, Thomas N. Rohrabaugh, and Lauren M. Loftus
- Subjects
Steric effects ,Denticity ,Ligand ,Chemistry ,Quantum yield ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Crystallography ,General Energy ,Excited state ,Density functional theory ,Molecular orbital ,Physical and Theoretical Chemistry ,0210 nano-technology ,Ground state - Abstract
A series of 12 Ru(II) complexes of the type [Ru(tpy)(L)(CH3CN)]n+, 1–12, containing the tridentate tpy ligand (tpy = 2,2′:6′,2″-terpyridine) and various bidentate ancillary ligands, L, were synthesized and evaluated for their ability to photodissociate CH3CN, a model for nitrile-containing drugs. Although the bidentate ligands chosen display a similar degree of steric bulk around the metal center in the ground state, the photosubstitution efficiencies of 1–12 vary by approximately an order of magnitude. The complexes containing the most electron-donating bidentate ligands, 8–11, exhibit the larger quantum yield values for ligand exchange in water. Complexes 8–11 also possess the smallest energy gap between the ground state and the lowest energy triplet metal-to-ligand charge transfer (3MLCT) excited state. In addition, density functional theory calculations indicate that a large degree of ligand character is present in their highest occupied molecular orbitals (HOMOs) and in their 3MLCT excited states. Th...
- Published
- 2019