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Start Over Author "Jeff G. Leid" Publisher american chemical society (acs)
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1. Utilization of Metal Halide Species Ambiguity to Develop Amorphous, Stabilized Pharmaceutical Agents As Ionic Liquids

Author

Emily K. Cope, Michael Valentine, Jeff G. Leid, Geraldine M Purdy, Rico E. Del Sesto, Katherine S. Lovejoy, John S. Wilkes, Andrew T. Koppisch, and Cynthia A. Corley

Subjects
Aqueous solution, Inorganic chemistry, Halide, Bioinorganic chemistry, General Chemistry, Condensed Matter Physics, Amorphous solid, Metal, chemistry.chemical_compound, chemistry, Chemical engineering, Polymorphism (materials science), visual_art, Ionic liquid, visual_art.visual_art_medium, General Materials Science
Abstract

A new strategy employs amorphous melts of active pharmaceutical agents, which are formed with metal chlorides, including ZnCl2, through speciation ambiguity. The Lewis acidic, bioinorganic ionic liquid formulations improve shelf life and water solubility and eliminate issues related to crystal polymorphism. This broad-ranging approach produces thermally robust chlorometallate preparations for use as lotions, antibiofilm agents, and in situations without refrigeration.

Published
2012
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