1. Arylation of Aldehydes To Directly Form Ketones via Tandem Nickel Catalysis
- Author
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Daoyong Zhu, Vicente Iii Tiu Tangcueco, Chuanhu Lei, and Jianrong Steve Zhou
- Subjects
inorganic chemicals ,Tandem ,Hydrogen ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,chemistry.chemical_element ,Substrate (chemistry) ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,0104 chemical sciences ,Catalysis ,Nickel ,Physical and Theoretical Chemistry - Abstract
A nickel-catalyzed arylation of both aliphatic and aromatic aldehydes proceeds with air-stable (hetero)arylboronic acids, with an exceptionally wide substrate scope. The neutral condition tolerates acidic hydrogen and sensitive polar groups and also preserves α-stereocenters of some chiral aldehydes. Interestingly, this nickel(0) catalysis does not follow common 1,2-insertion of arylmetal species to aldehydes and β-hydrogen elimination.
- Published
- 2019
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