173 results on '"Craik, David J."'
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2. Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide
3. Development of Melanocortin 4 Receptor Agonists by Exploiting Animal-Derived Macrocyclic, Disulfide-Rich Peptide Scaffolds
4. Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples
5. Structure–Activity Relationships of Alanine Scan Mutants αO-Conotoxins GeXIVA[1,2] and GeXIVA[1,4]
6. Development of Antiplasmodial Peptide–Drug Conjugates Using a Human Protein-Derived Cell-Penetrating Peptide with Selectivity for Infected Cells
7. Nematicidal Activity of Cyclotides: Toxicity Against Caenorhabditis elegans
8. Discovery, Characterization, and Engineering of LvIC, an α4/4-Conotoxin That Selectively Blocks Rat α6/α3β4 Nicotinic Acetylcholine Receptors
9. Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa
10. Improving Stability Enhances In Vivo Efficacy of a PCSK9 Inhibitory Peptide
11. Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists
12. Enzymatic C-Terminal Protein Engineering with Amines
13. Evaluation of Efficient Non-reducing Enzymatic and Chemical Ligation Strategies for Complex Disulfide-Rich Peptides
14. An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β-Factor XIIa in a Cyclotide Scaffold
15. Rational Design of Potent Peptide Inhibitors of the PD-1:PD-L1 Interaction for Cancer Immunotherapy
16. Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides
17. Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework
18. Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain
19. An Integrated Molecular Grafting Approach for the Design of Keap1-Targeted Peptide Inhibitors
20. Cyclic Peptides as T-Type Calcium Channel Blockers: Characterization and Molecular Mapping of the Binding Site
21. Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential
22. Engineered Conotoxin Differentially Blocks and Discriminates Rat and Human α7 Nicotinic Acetylcholine Receptors
23. Tuning the Anti-Angiogenic Effect of the P15 Peptide Using Cyclic Trypsin Inhibitor Scaffolds
24. Designed β-Hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity
25. In Planta Discovery and Chemical Synthesis of Bracelet Cystine Knot Peptides from Rinorea bengalensis
26. Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells
27. Computational and Functional Mapping of Human and Rat α6β4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs
28. Engineered EGF-A Peptides with Improved Affinity for Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)
29. Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes
30. Bioactive Cyclization Optimizes the Affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Peptide Inhibitor
31. Evaluation of the in Vivo Aphrodisiac Activity of a Cyclotide Extract from Hybanthus enneaspermus
32. Exploring the Sequence Diversity of Cyclotides from Vietnamese Viola Species
33. Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold
34. Circular Permutation of the Native Enzyme-Mediated Cyclization Position in Cyclotides
35. Enhanced Activity against Multidrug-Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway
36. Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA
37. Binding Loop Substitutions in the Cyclic Peptide SFTI-1 Generate Potent and Selective Chymase Inhibitors
38. Cyclotides: From Structure to Function
39. Is the Mirror Image a True Reflection? Intrinsic Membrane Chirality Modulates Peptide Binding
40. Cyclic Analogues of Horseshoe Crab Peptide Tachyplesin I with Anticancer and Cell Penetrating Properties
41. Conotoxins: Chemistry and Biology
42. Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase
43. Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants with Extended Antibacterial Properties
44. Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix–Loop–Helix Peptides with Cell Penetrating and Tumor Suppressor Properties
45. Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3
46. Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential
47. Amino Acid Scanning at P5′ within the Bowman–Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases
48. Toward Structure Determination of Disulfide-Rich Peptides Using Chemical Shift-Based Methods
49. Discovery and Characterization of Cyclic and Acyclic Trypsin Inhibitors from Momordica dioica
50. Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
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