1. A Dual Sensor Spin Trap for Use with EPR Spectroscopy
- Author
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Stuart T. Caldwell, Ruth Edge, Caroline Quin, and Richard C. Hartley
- Subjects
Cyclopropanes ,chemistry.chemical_classification ,Free Radicals ,Molecular Structure ,Spin trapping ,Radical ,Organic Chemistry ,Electron Spin Resonance Spectroscopy ,Nitroxyl ,Photochemistry ,Biochemistry ,Cyclopropane ,law.invention ,Nitrone ,chemistry.chemical_compound ,Phenols ,chemistry ,law ,Phenol ,Molecule ,Nitrogen Oxides ,Physical and Theoretical Chemistry ,Electron paramagnetic resonance ,Spin Trapping - Abstract
Redox active metal ions, carbon-centered radicals, and oxygen-centered radicals are important to oxidative stress. A radical detector combining a nitrone spin trap, a phenol, and a cyclopropane radical clocklike unit was prepared and used with EPR spectroscopy to detect and distinguish between hydroxyl radicals, methyl radicals, and iron(III) ions. Iron(III) reacts with the phenol unit inducing opening of the cyclopropane ring and cyclization to generate a stable nitroxyl radical.
- Published
- 2007
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