1. [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism
- Author
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Alvaro A. Ordonez, Valerie Carroll, Robert R. Flavell, Joseph E. Blecha, Matthew F.L. Parker, Christopher A. Mutch, David M. Wilson, Renuka Sriram, Henry F. VanBrocklin, Oren S. Rosenberg, Céline Taglang, Javier Villanueva-Meyer, Michael A. Ohliger, Lauren E. Bambarger, Hecong Qin, Kiel D. Neumann, and Sanjay K. Jain
- Subjects
0301 basic medicine ,biology ,medicine.diagnostic_test ,Chemistry ,Pathogenic bacteria ,Magnetic resonance imaging ,Metabolism ,Single-photon emission computed tomography ,medicine.disease_cause ,biology.organism_classification ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Metabolic pathway ,030104 developmental biology ,0302 clinical medicine ,Infectious Diseases ,Biochemistry ,Positron emission tomography ,TRACER ,medicine ,Bacteria - Abstract
Imaging studies are frequently used to support the clinical diagnosis of infection. These techniques include computed tomography (CT) and magnetic resonance imaging (MRI) for structural information and single photon emission computed tomography (SPECT) or positron emission tomography (PET) for metabolic data. However, frequently, there is significant overlap in the imaging appearance of infectious and noninfectious entities using these tools. To address this concern, recent approaches have targeted bacteria-specific metabolic pathways. For example, radiolabeled sugars derived from sorbitol and maltose have been investigated as PET radiotracers, since these are efficiently incorporated into bacteria but are poor substrates for mammalian cells. We have previously shown that para-aminobenzoic acid (PABA) is an excellent candidate for development as a bacteria-specific imaging tracer as it is rapidly accumulated by a wide range of pathogenic bacteria, including metabolically quiescent bacteria and clinical st...
- Published
- 2018