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The discovery of sulfoxaflor [N-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-λ(4)-sulfanylidene] cyanamide] resulted from an investigation of the sulfoximine functional group as a novel bioactive scaffold for insecticidal activity and a subsequent extensive structure-activity relationship study. Sulfoxaflor, the first product from this new class (the sulfoximines) of insect control agents, exhibits broad-spectrum efficacy against many sap-feeding insect pests, including aphids, whiteflies, hoppers, and Lygus, with levels of activity that are comparable to those of other classes of insecticides targeting sap-feeding insects, including the neonicotinoids. However, no cross-resistance has been observed between sulfoxaflor and neonicotinoids such as imidacloprid, apparently the result of differences in susceptibility to oxidative metabolism. Available data are consistent with sulfoxaflor acting via the insect nicotinic receptor in a complex manner. These observations reflect the unique structure of the sulfoximines compared with neonicotinoids.

DE-498 is a member of a new structural class of highly active herbicides, the triazolopyrimidine sulfonanilides, which act by inhibiting acetolactate synthase (EC 4.1.3.18). DE-498 exhibits broad spectrum activity on broad-leafed weed species with selectivity to several major agronomic crops in soil and foliar applications. The toxicological profile of DE-498 to mammals, fish, and wildlife is favorable. The moderate soil half-life and patterns of crop selectivity of DE-498 eliminate the potential for carryover injury to crops grown in corn/soybean/wheat rotations