1. Biocompatible Two-Dimensional Titanium Nanosheets for Multimodal Imaging-Guided Cancer Theranostics
- Author
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Mengmeng Qu, Shiyun Bao, Han Zhang, Taojian Fan, Jinlai Zhao, Yao Zhu, Shiyou Chen, Liping Liu, Zhitao Lin, Dianyuan Fan, Yang Li, Zhongjian Xie, Hong Chen, Yanhong Duo, and Qingshuang Zou
- Subjects
Materials science ,Biocompatibility ,Cell Survival ,chemistry.chemical_element ,Photoacoustic imaging in biomedicine ,Nanotechnology ,02 engineering and technology ,Multimodal Imaging ,01 natural sciences ,Theranostic Nanomedicine ,Nanocomposites ,Nanomaterials ,Photoacoustic Techniques ,010309 optics ,Cell Line, Tumor ,0103 physical sciences ,medicine ,Humans ,General Materials Science ,Titanium ,Cancer ,Surface Plasmon Resonance ,Photothermal therapy ,021001 nanoscience & nanotechnology ,medicine.disease ,Biocompatible material ,Combined Modality Therapy ,Nanostructures ,chemistry ,0210 nano-technology ,Localized surface plasmon - Abstract
Photothermal therapy (PTT) based on two-dimensional (2D) nanomaterials has shown significant potential in cancer treatment. However, developing 2D nanomaterial-based theranostic agents with good biocompatibility and high therapeutic efficiency remains a key challenge. Bulk titanium (Ti) has been widely used as biomedical materials for their reputable biocompatibility, whereas nanosized Ti with a biological function remains unexplored. In this work, the 2D Ti nanosheets (NSs) are successfully exfoliated from nonlayer bulk Ti and utilized as an efficient theranostic nanoplatform for dual-modal computed tomography/photoacoustic (CT/PA) imaging-navigated PTT. Besides the excellent biocompatibility obtained by TiNSs as expected, they are found to show strong absorption ability with an extinction coefficient of 20.8 L g-1 cm-1 and high photothermal conversion ability with an efficiency of 61.5% owing to localized surface plasmon resonances, which exceeds most of other well-known photothermal agents, making it quite promising for PTT against cancer. Furthermore, the metallic property and light-heat-acoustic transformation endow 2D Ti with the strong CT/PA imaging signal and efficient cancer therapy, simultaneously. This work highlights the enormous potential of nanosized Ti in both the diagnosis and treatment of cancer. As a paradigm, this study also paves a new avenue for the elemental transition-metal-based cancer theranostics.
- Published
- 2019