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A novel and atom-economic palladium-catalyzed isomerization-hydrocarbonylative cyclization reaction of 1,5-dienes to 2-alkylidenecyclopentanones has been developed, which provides a rapid and straightforward approach to 2-alkylidenecyclopentanones with high stereoselectivity. The reaction was found to proceed via alkene isomerization and selective hydrocarbonylative cyclization to generate 2-alkylidenecyclopentanones with high selectivity.

A new catalyst-free protocol for aminomethylamination of o-hydroxystyrenes with simple aminals is described. This direct and operationally simple method provides a fundamentally novel and rapid approach for the synthesis of 1,3-diamines. This novel reaction occurs under mild reaction conditions and provides a fundamentally unique and efficient strategy for the synthesis of 1,3-diamines with good to excellent yields.