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Your search keyword '"Zhi-Cai, Shi"' showing total 5 results
Start Over Author "Zhi-Cai, Shi" Publisher american chemical society
5 results on '"Zhi-Cai, Shi"'

2. A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions

Author

Michael K. Wismer, Guoqing Li, Zhi-Cai Shi, Rui Zhang, David W. C. MacMillan, Donald V. Conway, Petr Vachal, Chi Chip Le, and Ian W. Davies

Subjects
Protocol (science), Standardization, 010405 organic chemistry, business.industry, Chemistry, General Chemical Engineering, Scale (chemistry), Nanotechnology, General Chemistry, 010402 general chemistry, 7. Clean energy, 01 natural sciences, 0104 chemical sciences, lcsh:Chemistry, Chemical energy, Acceleration, chemistry.chemical_compound, lcsh:QD1-999, Photocatalysis, Photon capture, Organic synthesis, Process engineering, business, Research Article
Abstract

Photocatalysis for organic synthesis has experienced an exponential growth in the past 10 years. However, the variety of experimental procedures that have been reported to perform photon-based catalyst excitation has hampered the establishment of general protocols to convert visible light into chemical energy. To address this issue, we have designed an integrated photoreactor for enhanced photon capture and catalyst excitation. Moreover, the evaluation of this new reactor in eight photocatalytic transformations that are widely employed in medicinal chemistry settings has confirmed significant performance advantages of this optimized design while enabling a standardized protocol., An integrated photoreactor allows for enhanced photon capture and enables a standardized protocol for photocatalytic methodologies. The evaluation of this reactor in eight transformations showed significant rate enhancement and good reproducibility.

Published
2017

3. Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.

Author

Cernak, Tim, Gesmundo, Nathan J., Dykstra, Kevin, Yang Yu, Zhicai Wu, Zhi-Cai Shi, Vachal, Petr, Sperbeck, Donald, Shuwen He, Murphy, Beth Ann, Sonatore, Lisa, Williams, Steven, Madeira, Maria, Verras, Andreas, Reiter, Maud, Claire Heechoon Lee, Cuff, James, Sherer, Edward C., Kuethe, Jeffrey, and Goble, Stephen

Published
2017
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4. Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.

Author

Scott, Jack D., DeMong, Duane E., Greshock, Thomas J., Basu, Kallol, Xing Dai, Harris, Joel, Hruza, Alan, Li, Sarah W., Sue-Ing Lin, Hong Liu, Macala, Megan K., Zhiyong Hu, Hong Mei, Honglu Zhang, Walsh, Paul, Poirier, Marc, Zhi-Cai Shi, Li Xiao, Agnihotri, Gautam, and Baptista, Marco A. S.

Published
2017
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5. Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders.

Author

Zhi-Cai Shi, Arokiasamy Devasagayaraj, Kunjian Gu, Haihong Jin, Brett Marinelli, Lakshman Samala, Sheldon Scott, Terry Stouch, Ashok Tunoori, Ying Wang, Chengmin Zhang, S. David Kimball, Alan J. Main, Weimei Sun, Yi Zang, Qi Yang, Amr Nouraldeen, Xiang-Qing Yu, Eric Buxton, and Shiv Patel

Subjects
*SEROTONIN, *TRYPTOPHAN, *CHOLESTEROL hydroxylase, *GASTROINTESTINAL diseases
Abstract

The discovery of a novel class of peripheral tryptophan hydroxylase (TPH) inhibitors is described. This class of TPH inhibitors exhibits excellent potency in in vitro biochemical and cell-based assays, and it selectively reduces serotonin levels in the murine intestine after oral administration without affecting levels in the brain. These TPH1 inhibitors may provide novel treatments for gastrointestinal disorders associated with dysregulation of the serotonergic system, such as chemotherapy-induced emesis and irritable bowel syndrome. [ABSTRACT FROM AUTHOR]

Published
2008
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