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Your search keyword '"Yoshitomi M"' showing total 2 results
Start Over Author "Yoshitomi M" Publisher american chemical society
2 results on '"Yoshitomi M"'

1. Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase (ACAT).

Author

Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Horlad H, Ikeda T, Nohara T, Takeya M, and Nagai R

Subjects
Animals, Apolipoproteins E genetics, Atherosclerosis enzymology, Atherosclerosis genetics, Atherosclerosis metabolism, Cell Line, Cholesterol Esters metabolism, Cricetinae, Disease Models, Animal, Female, Foam Cells metabolism, Humans, Hyperlipidemias enzymology, Hyperlipidemias genetics, Hyperlipidemias metabolism, Mice, Mice, Inbred C57BL, Mice, Knockout, Sterol O-Acyltransferase genetics, Sterol O-Acyltransferase metabolism, Tomatine administration & dosage, Apolipoproteins E deficiency, Atherosclerosis drug therapy, Down-Regulation, Hyperlipidemias drug therapy, Solanum lycopersicum chemistry, Plant Extracts administration & dosage, Sterol O-Acyltransferase antagonists & inhibitors, Tomatine analogs & derivatives
Abstract

It was previously revealed that esculeoside A, a new glycoalkaloid, and esculeogenin A, a new aglycon of esculeoside A, contained in ripe tomato ameliorate atherosclerosis in apoE-deficent mice. This study examined whether tomatidine, the aglycone of tomatine, which is a major tomato glycoalkaloid, also shows similar inhibitory effects on cholesterol ester (CE) accumulation in human monocyte-derived macrophages (HMDM) and atherogenesis in apoE-deficient mice. Tomatidine significantly inhibited the CE accumulation induced by acetylated LDL in HMDM in a dose-dependent manner. Tomatidine also inhibited CE formation in Chinese hamster ovary cells overexpressing acyl-CoA:cholesterol acyl-transferase (ACAT)-1 or ACAT-2, suggesting that tomatidine suppresses both ACAT-1 and ACAT-2 activities. Furthermore, the oral administration of tomatidine to apoE-deficient mice significantly reduced levels of serum cholesterol, LDL-cholesterol, and areas of atherosclerotic lesions. The study provides the first evidence that tomatidine significantly suppresses the activity of ACAT and leads to reduction of atherogenesis.

Published
2012
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2. Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages.

Author

Fujiwara Y, Hayashida A, Tsurushima K, Nagai R, Yoshitomi M, Daiguji N, Sakashita N, Takeya M, Tsukamoto S, and Ikeda T

Subjects
Atherosclerosis drug therapy, Cells, Cultured, Foam Cells cytology, Fruit chemistry, Humans, Macrophages cytology, Plant Extracts isolation & purification, Triterpenes isolation & purification, Atherosclerosis prevention & control, Down-Regulation drug effects, Foam Cells drug effects, Macrophages drug effects, Plant Extracts pharmacology, Triterpenes pharmacology, Ziziphus chemistry
Abstract

Because foam cell formation in macrophages is believed to play an essential role in the progression of early atherosclerotic lesions in vivo, prevention of foam cell formation is considered to be one of the major targets for the treatment of atherosclerosis. The present study examined the inhibitory effect of 50 crude plant extracts on foam cell formation. Among those crude extracts, Zizyphi Fructus (ZF) and Zizyphi Semen (ZS) extracts significantly inhibited the foam cell formation induced by acetylated LDL. Furthermore, triterpenoids such as oleanonic acid, pomolic acid, and pomonic acid were the major active compounds, and triterpenoids containing a carboxylic acid at C-28 play an important role in the inhibitory effect on foam cell formation in human macrophages. These data suggest that triterpenoids in Zizyphus jujuba , the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis.

Published
2011
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