1. "Fruiting Liquid" of Mushroom-Forming Fungi, A Novel Source of Bioactive Compounds - Fruiting-Body Inducer and HIF and Axl Inhibitors.
- Author
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Wu J, Uchida K, Yoshikawa A, Hashimoto M, Kondo M, Nihei K, Ishii M, Choi JH, Miwa Y, Shoda C, Lee D, Nakai A, Kurihara T, D'Alessandro-Gabazza CN, Toda M, Yasuma T, Gabazza EC, Hirai H, and Kawagishi H
- Subjects
- Crystallography, X-Ray, Fruit, Agaricales, Ascomycota, Flammulina
- Abstract
In general, mushroom-forming fungi secrete liquid on the surface of mycelia just before fruiting-body formation. However, no researchers in mushroom science have paid attention to the liquid until now. We formulated a hypothesis that the liquid plays an important role(s) in the formation of the fruiting body and produces various bioactive compounds and named it the "fruiting liquid (FL)". Four novel compounds ( 1 - 4 ) were isolated from FL of Hypholoma lateritium and Hericium erinaceus . The structures of 1 - 4 except for their stereochemistry were determined by interpretation of MS and NMR data. The absolute configurations of compounds 1 - 4 were determined by quantum chemical calculation of the ECD spectrum, by single-crystal X-ray diffraction analyses, or by chemical syntheses. Compounds 1 , 3 , and 4 induced fruiting body formation of Flammulina velutipes . Compound 4 inhibited the activity of hypoxia-inducible factor, and compounds 2 - 4 suppressed receptor tyrosine kinase (Axl) expression.
- Published
- 2023
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