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Your search keyword '"Yamamoto, Taichi"' showing total 2 results
Start Over Author "Yamamoto, Taichi" Publisher american chemical society
2 results on '"Yamamoto, Taichi"'

1. Molecular studies of pH-dependent ligand interactions with the low-density lipoprotein receptor

Author

Yamamoto, Taichi, Hsuan-Chih Chen, Guigard, Emmanuel, Kay, Cyril M., and Ryan, Robert O.

Subjects
Histidine -- Chemical properties, Ligand binding (Biochemistry) -- Analysis, Low density lipoproteins -- Chemical properties, Mutagenesis -- Analysis, Biological sciences, Chemistry
Abstract

A site-directed mutagenesis studies were carried out to understand the role of histidines His190, His562, and His586 in recombinant soluble low-density lipoprotein receptor (sLDLR) in pH-dependent ligand binding and discharge. The data obtained confirmed the existence of a cryptic, histidine side chain ionization-dependent alternative ligand that regulates ligand discharge via conformational reorganization.

Published
2008

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