Search

Your search keyword '"Xu, Jing‐Juan"' showing total 259 results
Start Over Author "Xu, Jing‐Juan" Publisher american chemical society
259 results on '"Xu, Jing‐Juan"'

36. Near-Infrared-Driven Plasmon-Enhanced Au@PtAg Cascade Nanozymes for Cancer Therapy.

Author

Zhou, Jie, Yang, Xue-Jiao, Yu, Qiao, Li, Xiang-Ling, Chen, Hong-Yuan, and Xu, Jing-Juan

Abstract

Nanozymes with cascade catalytic reactions gain advantages over natural enzymes by simplifying the preparation, decreasing the cost, and enhancing the local concentrations of the intermediates and the stability. However, in vivo applications of such cascade nanozymes are hampered due to the low catalytic activity in the complex physiological microenvironment. Substantial research work is currently devoted to exploiting light-driven catalytic kinetic acceleration of nanozymes via hot electron injection from plasmonic nanoparticles. Here, a near-infrared (NIR) light-driven plasmon-enhanced cascade nanozyme with a formulation of Au@Pt0.46Ag0.54 is developed for efficient synergistic cancer therapy. This nanozyme possesses catalase, oxidase, and peroxidase activities and is capable of converting hydrogen peroxide to oxygen and reactive oxygen species through cascade reactions. Both in vitro and in vivo experimental measurements reveal that 808 nm NIR-laser-driven hot electron injection not only obviously enhanced the catalytic activities of the nanozyme but also triggered efficient photothermal conversion, which successfully achieved synergetic catalytic therapy/photothermal therapy for cancer treatment. This strategy of tailoring multi-metal cascade nanozyme techniques opens up avenues for realizing multistep reactions with high catalytic kinetics and provides an innovative way for therapeutic systems with clinical significance. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

38. Electrochemical identification of the property of peripheral nerve fiber based on a biocompatible polymer film via in situ incorporating gold nanoparticles

Author

Zhao, Wei, Sun, Si-Xin, Xu, Jing-Juan, Chen, Hong-Yuan, Cao, Xiao-Jian, and Guan, Xiao-Hong

Subjects
Electrochemistry -- Research, Nerves, Peripheral -- Electric properties, Nerves, Peripheral -- Chemical properties, Polymers in medicine -- Properties, Nanoparticles -- Properties, Chemistry
Abstract

We report a simple electrochemical method for the identification of properties of peripheral nerve fibers, based on the detection of a neurotransmitter enzyme, acetylcholinesterase (ACHE). A poly(diallydimethylammonium) (PDDA) adulterated poly(dimethylsiloxane) (PDMS) film is spin-coated on the surface of gold electrodes. Gold nanoparticles (AuNPs) are in situ synthesized on the polymer film, which act as 'electron antennae' between the film and the electrode surface and also provide a biocompatible interface. This PDMS--PDDA/AuNPs film shows different adsorption sites to choline oxidase (ChO) and ACHE; after incubation with ChO, the polymer--gold nanocomposite film also shows excellent adsorption ability to ACHE. Moreover the adsorption sites of AChE would not be blocked by bovine serum albumin (BSA) which provides a good platform for the quantitative amperometric determination of AChE via the oxidation of the enzymatically generated [H.sub.2][O.sub.2] in the bienzyme system in the presence of acetylcholine. The detection limit is down to 1.0 unit/mL. The polymer--gold nanocomposite film shows excellent anti-interference ability to the coexistent electroactive substances such as ascorbic acid. Thus it was applied to determine AChE in peripheral nerve fibers homogenates and identify the motor and sensory fibers for the first time. Compared with histochemical staining methods, the electrochemical technique shows good accurate rate and faster response, which has good potential for a clinical application.

Published
2008

39. Electrochemical detection method for nonelectroactive and electroactive analytes in microchip electrophoresis

Author

Xu, Jing-Juan, Bao, Ning, Xia, Xing-Hua, Peng, Ying, and Chen, Hong-Yuan

Subjects
Electrophoresis -- Research, Chemistry
Abstract

In this work, we establish an indirect amperometric detection method via mounting a single carbon fiber disk working electrode in the end part of a microchannel. This in-channel configuration for microchip capillary electrophoresis brings about that the potential of the working electrode in the case of electrochemical reduction reaction is coupled by the separation electric field, while the potential of the working electrode in the case of electrochemical oxidation reaction is not coupled by the separation electric field. Such a special performance provides a convenient and sensitive approach for indirectly detecting nonelectroactive analytes that relies on amperometric response of dissolved oxygen in solution and directly detecting electroactive analytes based on their own amperometric response on the carbon fiber electrode. This method has shown its essential importance in the analysis of inorganic cations, biomolecules, and electroosmotic flow rates. Based on preliminary results, a detection limit of 1.0 [micro]M for [K.sup.+] and [Na.sup.+] have been achieved.

Published
2004

Catalog

Books, media, physical & digital resources
See catalog results