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Your search keyword '"Wu, Zi‐Yi"' showing total 2 results
Start Over Author "Wu, Zi‐Yi" Publisher american chemical society
2 results on '"Wu, Zi‐Yi"'

2. Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.

Author

Liou JP, Wu ZY, Kuo CC, Chang CY, Lu PY, Chen CM, Hsieh HP, and Chang JY

Subjects
Cell Line, Tumor, Humans, Magnetic Resonance Spectroscopy, Spectrometry, Mass, Electrospray Ionization, Tubulin chemistry, Biopolymers chemistry, Indoles chemistry, Indoles pharmacology, Tubulin drug effects
Abstract

1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC 50 of 0.9 and 0.6 microM, respectively, exhibited antitubulin activity superior or comparable to that of colchicine and combretastatin A-4. They also showed antiproliferative activity with IC 50 of 0.3-5.4 nM in a set of human cancer cell lines.

Published
2008
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