7 results on '"Whitehead, Todd"'
Search Results
2. Temporal Trends of Insecticide Concentrations in Carpet Dust in California from 2001 to 2006.
- Author
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Gunier, Robert B., Nuckols, John R., Whitehead, Todd P., Colt, Joanne S., Deziel, Nicole C., Metayer, Catherine, Reynolds, Peggy, and Ward, Mary H.
- Published
- 2016
- Full Text
- View/download PDF
3. High Levels of Polybrominated Diphenyl Ethers in Vacuum Cleaner Dust from California Fire Stations.
- Author
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Beverly Shen, Whitehead, Todd P., McNeel, Sandra, Reber Brown, F., Dhaliwal, Joginder, Das, Rupali, Israel, Leslie, June-Soo Park, and Petreas, Myrto
- Subjects
- *
POLYBROMINATED diphenyl ethers , *VACUUM cleaners , *FIRE stations , *POLYCYCLIC aromatic hydrocarbons , *POLYCHLORINATED biphenyls - Abstract
Firefighters are exposed to chemicals during lire events and may also experience chemical exposure in their fire stations. Dust samples from used vacuum cleaner bags were collected from 20 fire stations in California and analyzed for polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) using gas chromatography--mass spectrometry. Median dust concentrations were higher for PBDEs (e.g., 47 000 ng/g for BDE-209) than for PAHs (e.g., 220 ng/g for benzo[a]pyrene) or PCBs (e.g., 9.3 ng/g for PCB-180). BDE-209 concentrations in dust from California fire stations were among the highest of any previously documented homes or occupational settings in the world. We examined factors such as the frequency of emergency responses, the number of fire vehicles on site, and building age, but we could not account for the high levels of BDE-209 observed in fire station dust. Based on the findings of our pilot study, we hypothesize that possible sources of BDE-209 in fire stations include contaminated ash tracked back from fire events via boots, clothing, and other equipment as well as specialized equipment treated with BDE-209, including turnout gear and fire vehicles. We suggest possible followup studies to confirm these hypotheses. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
4. Polychlorinated Biphenyls in Residential Dust: Sources of Variability.
- Author
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Whitehead, Todd P., Reber Brown, F., Metayer, Catherine, June-Soo Park, Does, Monique, Dhaliwal, Joginder, Petreas, Myrto X., Buffler, Patricia A., and Rappaport, Stephen M.
- Subjects
- *
POLYCHLORINATED biphenyls , *VACUUM cleaners , *GAS chromatography/Mass spectrometry (GC-MS) , *BIPHENYL compounds , *CHILDREN'S health - Abstract
We characterized the variability in concentrations of polychlorinated biphenyls (PCBs) measured in residential dust. Vacuum cleaner samples were collected from 289 homes in the California Childhood Leukemia Study during two sampling rounds from 2001 to 2010 and 15 PCBs were measured by high resolution gas chromatography-mass spectrometry. Median concentrations of the most abundant PCBs (i.e., PCBs 28, 52, 101, 105, 118, 138, 153, and 180) ranged from 1.0-5.8 ng per g of dust in the first sampling round and from 0.8-3.4 ng/g in the second sampling round. For each of these eight PCBs, we used a random-effects model to apportion total variation into regional variability (6-11%), intraregional between-home variability (27-56%), withinhome variability over time (18-52%), and within-sample variability (9-16%). In mixed-effects models, differences in PCB concentrations between homes were explained by home age, with older homes having higher PCB levels. Differences in PCB concentrations within homes were explained by decreasing time trends. Estimated half-lives ranged from 5-18 years, indicating that PCBs are removed very slowly from the indoor environment. Our findings suggest that it may be feasible to use residential dust for retrospective assessment of PCB exposures in studies of children's health. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
5. Concentrations of Persistent Organic Pollutants in California Children's Whole Blood and Residential Dust.
- Author
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Whitehead TP, Crispo Smith S, Park JS, Petreas MX, Rappaport SM, and Metayer C
- Subjects
- Adolescent, Adult, Breast Feeding, California, Child, Child, Preschool, Dichlorodiphenyl Dichloroethylene blood, Female, Gas Chromatography-Mass Spectrometry, Halogenated Diphenyl Ethers blood, Housing, Humans, Hydrocarbons, Chlorinated blood, Leukemia blood, Male, Odds Ratio, Pesticides blood, Polybrominated Biphenyls blood, Polychlorinated Biphenyls blood, Dust analysis, Organic Chemicals blood
- Abstract
We evaluated relationships between persistent organic pollutant (POP) levels in the blood of children with leukemia and POP levels in dust from their household vacuum cleaners. Blood and dust were collected from participants of the California Childhood Leukemia Study at various intervals from 1999 to 2007 and analyzed for two polybrominated diphenyl ethers (PBDEs), two polychlorinated biphenyls (PCBs), and two organochlorine pesticides using gas chromatography-mass spectrometry. Due to small blood sample volumes (100 μL), dichlorodiphenyldichloroethylene (DDE) and BDE-153 were the only analytes with detection frequencies above 70%. For each analyte, depending on its detection frequency, a multivariable linear or logistic regression model was used to evaluate the relationship between POP levels in blood and dust, adjusting for child's age, ethnicity, and breastfeeding duration; mother's country of origin; household annual income; and blood sampling date. In linear regression, concentrations of BDE-153 in blood and dust were positively associated; whereas, DDE concentrations in blood were positively associated with breastfeeding, maternal birth outside the U.S., and Hispanic ethnicity, but not with corresponding dust-DDE concentrations. The probability of PCB-153 detection in a child's blood was marginally associated with dust-PCB-153 concentrations (p = 0.08) in logistic regression and significantly associated with breastfeeding. Our findings suggest that dust ingestion is a source of children's exposure to certain POPs.
- Published
- 2015
- Full Text
- View/download PDF
6. Tobacco alkaloids and tobacco-specific nitrosamines in dust from homes of smokeless tobacco users, active smokers, and nontobacco users.
- Author
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Whitehead TP, Havel C, Metayer C, Benowitz NL, and Jacob P 3rd
- Subjects
- Carcinogens analysis, Child, Chromatography, Liquid, Humans, Tandem Mass Spectrometry, Nicotiana chemistry, Air Pollution, Indoor analysis, Alkaloids analysis, Dust analysis, Nitrosamines analysis, Tobacco Smoke Pollution analysis, Tobacco, Smokeless analysis
- Abstract
Smokeless tobacco products, such as moist snuff or chewing tobacco, contain many of the same carcinogens as tobacco smoke; however, the impact on children of indirect exposure to tobacco constituents via parental smokeless tobacco use is unknown. As part of the California Childhood Leukemia Study, dust samples were collected from 6 homes occupied by smokeless tobacco users, 6 homes occupied by active smokers, and 20 tobacco-free homes. To assess children's potential for exposure to tobacco constituents, vacuum-dust concentrations of five tobacco-specific nitrosamines, including N'-nitrosonornicotine [NNN] and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone [NNK], as well as six tobacco alkaloids, including nicotine and myosmine, were quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). We used generalized estimating equations derived from a multivariable marginal model to compare levels of tobacco constituents between groups, after adjusting for a history of parental smoking, income, home construction date, and mother's age and race/ethnicity. The ratio of myosmine/nicotine was used as a novel indicator of the source of tobacco contamination, distinguishing between smokeless tobacco products and tobacco smoke. Median dust concentrations of NNN and NNK were significantly greater in homes with smokeless tobacco users compared to tobacco-free homes. In multivariable models, concentrations of NNN and NNK were 4.8- and 6.9-fold higher, respectively, in homes with smokeless tobacco users compared to tobacco-free homes. Median myosmine/nicotine ratios were lower in homes with smokeless tobacco users (1.8%) compared to homes of active smokers (7.7%), confirming that cigarette smoke was not the predominant source of tobacco constituents in homes with smokeless tobacco users. Children living with smokeless tobacco users may be exposed to carcinogenic tobacco-specific nitrosamines via contact with contaminated dust and household surfaces.
- Published
- 2015
- Full Text
- View/download PDF
7. High levels of polybrominated diphenyl ethers in vacuum cleaner dust from California fire stations.
- Author
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Shen B, Whitehead TP, McNeel S, Brown FR, Dhaliwal J, Das R, Israel L, Park JS, and Petreas M
- Subjects
- California, Gas Chromatography-Mass Spectrometry, Humans, Pilot Projects, Vacuum, Dust analysis, Firefighters, Halogenated Diphenyl Ethers analysis
- Abstract
Firefighters are exposed to chemicals during fire events and may also experience chemical exposure in their fire stations. Dust samples from used vacuum cleaner bags were collected from 20 fire stations in California and analyzed for polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) using gas chromatography-mass spectrometry. Median dust concentrations were higher for PBDEs (e.g., 47 000 ng/g for BDE-209) than for PAHs (e.g., 220 ng/g for benzo[a]pyrene) or PCBs (e.g., 9.3 ng/g for PCB-180). BDE-209 concentrations in dust from California fire stations were among the highest of any previously documented homes or occupational settings in the world. We examined factors such as the frequency of emergency responses, the number of fire vehicles on site, and building age, but we could not account for the high levels of BDE-209 observed in fire station dust. Based on the findings of our pilot study, we hypothesize that possible sources of BDE-209 in fire stations include contaminated ash tracked back from fire events via boots, clothing, and other equipment as well as specialized equipment treated with BDE-209, including turnout gear and fire vehicles. We suggest possible follow-up studies to confirm these hypotheses.
- Published
- 2015
- Full Text
- View/download PDF
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