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As a dangerous cardiovascular disease, acute myocardial infarction (AMI) has taken the lives of countless patients. Symptom onset of AMI is accompanied by a high amount of AMI biomarkers, including creatine kinase isoenzyme (CK-MB), troponin I (CTn I), and myoglobin (Mb). On the other hand, aspirin is an effective curing drug for AMI. Herein, we applied the layer-by-layer (LBL) synthesis strategy to form stratified magnetic core/multishell lanthanide metal–organic framework (Ln-MOF) Fe2O3@SiO2@Eu-MOF@Tb-MOF (MagMOF) nanoballs. Further, target mRNA sequence and antibodies (NH2-mRNA, anti-CTn, and anti-Mb) for AMI biomarkers are combined with MagMOF, respectively. They can be utilized as a hybrid sensing platform for the detection of CK-MB, Mb, and CTn I with high sensitivity (the limit of detection (LOD) for CK-MB is 174.98 U L–1, for CTn I is 0.16 mg L–1, and for Mb is 0.94 mg L–1). The detection ranges of MagMOF toward CK-MB, Mb, and CTn I in human serum have covered their maximum normal range in the human body, respectively. Further, MagMOF was applied in the ratiometric detection of aspirin with high sensitivity and low limit detection (LOD = 0.43 μM). As a result, MagMOF is the first example of realizing stable, susceptible, fast, and convenient detection of these AMI biomarkers and curing drug aspirin. [ABSTRACT FROM AUTHOR]

Through powerful solvothermal and facile ultrasonic synthetic strategies, two unique cluster-based lanthanide Lu and Y nanoporous metal organic frameworks (MOFs) have been successfully prepared, namely, {[Lu 2 (L) 2 ]·2DMF·H 2 O} n ( Lu-MOF ) and [Y(L)(DMF) 0.75 ] n ( Y-MOF ) (H 3 L = terphenyl-3,4'',5-tricarboxylic acid). In addition, both the morphologies and nanosizes of Lu-MOF and Y-MOF materials also have been deliberately tuned by adjustable ultrasonic conditions including irradiation time (40, 60, and 80 min) and power (70 w, 100 w). Currently, it is noted that the abuse of antibiotics such as ornidazole and ronidazole leads to great damage to human health, and therefore the development of highly effective and facile detection methods for ornidazole and ronidazole is quite important. Herein, to improve the fluorescent sensing sensitivity of antibiotics, Eu 3+ and Tb 3+ have been introduced into Lu-MOF (under a solvothermal preparation method) to fabricate a dual-emission hybrid material Eu 3+ /Tb 3+ @Lu-MOF through a postsynthesis strategy, which can be successfully applied as a self-calibrated ratiometric fluorescent sensor for ornidazole and ronidazole with high selectivity and sensitivity (the K sv value for ornidazole is 1.0854 × 10 6 [M -1 ], and the K sv value for ronidazole is 1.0595 × 10 7 [M -1 ]) and low detection limit values (2.85 nM for ornidazole and 26.7 nM for ronidazole). On the other hand, amoeba liver abscess (ALA) will easily lead to irregular fever, night sweats, and other tortured symptoms; C-reactive protein autoantibody (CRP Ab) is the important biomarker for the detection of ALA. Given this, Y-MOF (under the solvothermal preparation method) also has been successfully designed to combine FAM-labeled NH-ssDNA to construct the scarcely reported excellent hybrid FAM-labeled NH-ssDNA/ Y-MOF sensing platform for the highly effective discrimination of CRP Ab with excellent sensitivity and selectivity in real samples such as human serum solution.

Through the powerful hydrothermal method, five rare-earth (Re = Dy, Gd, Ho, Pr, and Sm) three-dimensional (3D) cluster-based metal-organic frameworks (MOFs) have been synthesized, namely, [Dy(L)(H 2 O)(DMF)] n (1), {[Gd(L)(H 2 O)(DMF)]·DMF} n (2), {[Ho(L)(H 2 O)(DMF)]·0.5DMF} n (3), {[Pr(L)(H 2 O)(DMF)]·0.5DMF} n (4), and {[Sm(L)(H 2 O) 1.55 (DMF) 0.45 ]·DMF} n (5; H 3 L = terphenyl-3,4″,5-tricarboxylic acid), which have been determined by single crystal X-ray analyses and PXRD characterization. Structural analyses reveal that, in 1-5, these L 3- ligands are linked by five different rare-earth centers, forming the iso-structural nanoporous frameworks. PXRD patterns of bulky samples 1-5 also are consistent with theoretical PXRD patterns confirming their purity. Solid state photoluminesce of free H 3 L and 1-5 at room temperature also has been investigated indicating strong ligand-based emissions. Besides these, fluorescent dye Rhodamine B (RhB) can be introduced into MOF1 forming the composite material RhB@MOF1 with a high quantum yield of 35%. It is noted that, through deliberately tuning the morphologies of nanoparticle MOF1 under different ultrasonic conditions, RhB@MOF1 can be utilized as the first ratiometric fluorescent sensor to effectively discriminate l- and d-lysine from other amino acid molecules with high K sv values and low LOD values. On the other hand, 2 was for the first time to be utilized as an excellent bifunctional MOFs-based sensing platform to detect insulin and Al 3+ with a low detection limit in the human serum solution.