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Your search keyword '"Tu, Wen-Chao"' showing total 2 results
Start Over Author "Tu, Wen-Chao" Publisher american chemical society
2 results on '"Tu, Wen-Chao"'

2. Hypophyllins A-D, Labdane-Type Diterpenoids with Vasorelaxant Activity from Hypoestes phyllostachya "Rosea".

Author

Wu XD, Luo D, Tu WC, Deng ZT, Chen XJ, Su J, Ji X, and Zhao QS

Subjects
Animals, Diterpenes chemistry, Diterpenes isolation & purification, Dose-Response Relationship, Drug, Molecular Conformation, Plant Components, Aerial chemistry, Potassium Chloride pharmacology, Rats, Stereoisomerism, Structure-Activity Relationship, Vasodilator Agents chemistry, Vasodilator Agents isolation & purification, Acanthaceae chemistry, Aorta, Thoracic drug effects, Diterpenes pharmacology, Endothelium, Vascular drug effects, Vasodilator Agents pharmacology
Abstract

Three rearranged labdane-type diterpenoids, hypophyllins A-C (1-3), and a caged labdane diterpenoid possessing a 8,9-dioxatricyclic[4.2.1.1 3,7 ]decane moiety, hypophyllin D (4), as well as two new biogenetically related diterpernoids, hypophyllins E (5) and F (6), were isolated from the aerial parts of Hypoestes phyllostachya "Rosea". The absolute configurations of 1-4 were determined by X-ray diffraction analysis. The plausible biogenetic pathway for 1-4 was also proposed. Compounds 4 and 5 showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.

Published
2016
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