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Start Over Author "Szego, Michael" Publisher american chemical society
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1. Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells

Author

Pardossi-Piquard, Raphaelle, Silva-Gagliardi, Nancy F., Szego, Michael, McInnes, Roderick, MeGlade, Jane C., George-Hyslop, Peter St., and Fraser, Paul E.

Subjects
Fluorescent antibody technique -- Analysis, Immunofluorescence -- Analysis, Membrane proteins -- Structure, Proteolysis -- Research, Western immunoblotting -- Analysis, Biological sciences, Chemistry
Abstract

A study was conducted to identify the functional interactions between the isoforms human Crumbs homologues (CRB) and presenilin complexes. The results suggest that CRB homologues are not directly implicated in mediating presenilin-dependent [gamma]/E-secretase activity.

Published
2007

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