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Your search keyword '"Qiao, Ming-Ming"' showing total 2 results
Start Over Author "Qiao, Ming-Ming" Publisher american chemical society
2 results on '"Qiao, Ming-Ming"'

2. Curcumanes A and B, Two Bicyclic Sesquiterpenoids with Significant Vasorelaxant Activity from Curcuma longa.

Author

Liu Y, Liu F, Qiao MM, Guo L, Chen MH, Peng C, and Xiong L

Subjects
Animals, Calcium Channel Blockers chemistry, Calcium Channel Blockers isolation & purification, Polycyclic Sesquiterpenes chemistry, Polycyclic Sesquiterpenes isolation & purification, Rats, Receptors, Calcium-Sensing metabolism, Vasodilator Agents chemistry, Vasodilator Agents isolation & purification, Aorta, Thoracic drug effects, Calcium Channel Blockers pharmacology, Calcium Channels metabolism, Curcuma chemistry, Polycyclic Sesquiterpenes pharmacology, Receptors, Calcium-Sensing antagonists & inhibitors, Vasodilator Agents pharmacology
Abstract

Two novel sesquiterpenoids, curcumanes A (1) and B (2), possessing unprecedented skeletons with a dicyclo[3.2.1]octane and a dicyclo[3.3.1]nonane moiety, respectively, were isolated from Curcuma longa. Both of them had remarkable vasorelaxant activity on rat aorta via blocking extracellular Ca 2+ influx through VDCCs and ROCCs. The activity of 1 was endothelium-independent, while that of 2 was endothelium-dependent. Compound 2 also prolonged APTT and TT to inhibit blood coagulation.

Published
2019
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