Patravale, Ajinkya A., Gore, Anil H., Patil, Dipti R., Kolekar, Govind B., Deshmukh, Madhukar B., and Anbhule, Prashant V.
The present study describes an alkalinewater–ethanol mediatedseries of combinatorial synthesis of 2-amino-4-phenyl-5-H-indeno[1,2d]pyrimidine-5-one derivatives throughsequential multicomponent reaction of 1,3indandione, aromatic aldehydes,and guanidine hydrochloride along with their anticancer evaluation.The effect of sequential addition of the components in the configurationof the desired product has been studied by UV–visible absorptionspectroscopy. The synthetic method obeys most of the green chemistryprinciples in regard to high atom economy and greener, nontoxic, andnoncarcinogenic solvent system (water–ethanol). The selectedsynthesized compounds have been screened against the human breastcancer cell line MCF7, human colon cancer cell line HT29, and normalviro monkey cell line, out of which 2-amino-4-(4-methoxyphenyl)-5H-indeno[1,2-d]pyrimidin-5-one showedsignificant potency toward human breast cancer cell line (MCF7). [ABSTRACT FROM AUTHOR]