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1. Mutational Analysis of the Thyrotropin-Releasing Hormone-Degrading Ectoenzyme. Similarities and...

Author

Papadopoulos, Theofilos, Kelly, Julie A., and Bauer, Karl

Subjects
*BINDING sites, *THYROTROPIN releasing factor, *PEPTIDASE, *ENZYME inhibitors
Abstract

Examines the organization of the active site of the thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE), a TRH-specific peptidase that catalyzes the inactivation of the peptidergic signal substance TRH. Enzymatic activity of wild-type and mutated TRH-DEs and the inhibitory potencies of various classes of inhibitors; Differences in the evolution of the active sites and in the mechanism of action between TRH-DE and APA.

Published
2001
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