36 results on '"P. Kania"'
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2. The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition.
3. Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
4. C(sp3)–H Oxidative Addition at Tantalocene Hydrides.
5. Design and Synthesis of Functionally Active 5‑Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
6. Optimal Solution to the Torsional Coefficient Fitting Problem in Force Field Parametrization.
7. Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
8. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis.
9. Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
10. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5...
11. Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR...
12. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
13. Efficient Isotope Editing of Proteins for Site-Directed Vibrational Spectroscopy.
14. Effect of Pregnancyon the Disposition of 2,2′,3,5′,6-Pentachlorobiphenyl(PCB 95) Atropisomers and Their Hydroxylated Metabolites in FemaleMice.
15. SpectroscopicProperties of Benzene at the Air–IceInterface: A Combined Experimental–Computational Approach.
16. High-Pressure and Theoretical Studies Reveal Significant Differences in the Electronic Structure and Bonding of Magnesium, Zinc, and Nickel Ions in Metalloporphyrinoids.
17. Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile(PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase(ALK) and c-ros...
18. Design of Potent and SelectiveInhibitors to Overcome Clinical Anaplastic Lymphoma Kinase MutationsResistant to Crizotinib.
19. Stereoselective Formation of Mono- and Dihydroxylated Polychlorinated Biphenyls by Rat Cytochrome P450 2B1.
20. Chlordane and Heptachlor Are Metabolized Enantioselectively by Rat Liver Microsomes.
21. 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and Its Hydroxylated Metabolites Are Enantiomerically Enriched in Female Mice.
22. Discovery of Pyrroloaminopyrazolesas Novel PAK Inhibitors.
23. 2,2′,3,3′,6,6′-Hexachlorobiphenyl (PCB 136) Is Enantioselectively Oxidized to Hydroxylated Metabolites by Rat Liver Microsomes.
24. Gas Chromatographic Analysis with Chiral Cyclodextrin Phases Reveals the Enantioselective Formation of Hydroxylated Polychlorinated Biphenyls by Rat Liver Microsomes.
25. Time Course of Congener Uptake and Elimination in Rats after Short-Term Inhalation Exposure to an Airborne Polychlorinated Biphenyl (PCB) Mixture.
26. Clearance of Polychlorinated Biphenyl Atropisomers is Enantioselective in Female C57BI/6 Mice.
27. Chiral Polychlorinated Biphenyl Transport Metabolism, and Distribution: A Review.
28. Series of MI[Co(bpy)3][Mo(CN)8]·nH2O (MI = Li (1), K (2), Rb (3), Cs (4); n = 7-8) Exhibiting Reversible Diamagnetic to Paramagnetic Transition Coupled with Dehydration-Rehydration Process.
29. Characterizing the Effects of the Juxtamembrane Domain on Vascular Endothelial Growth Factor Receptor-2 Enzymatic Activity, Autophosphorylation, and Inhibition by Axitinib.
30. 2,2′,3,3′,6,6′-Hexachlorobiphenyl (PCB 136) Atropisomers Interact Enantioselectively with Hepatic Microsomal Cytochrome P450 Enzymes.
31. Structure-Based Design and Synthesis of (5-Arylamino-2H-pyrazol-3-yl)-biphenyl-2‘,4‘-diols as Novel and Potent Human CHK1 Inhibitors.
32. Distribution of Chiral PCBs in Selected Tissues in the Laboratory Rat.
33. Congener-Specific Tissue Distribution of Aroclor 1254 and a Highly Chlorinated Environmental PCB Mixture in Rats.
34. Degradation of monoubiquitinated alpha-globin by 26S proteasomes.
35. Geometry and microwave rotational spectrum of the FC16O18O• radical.
36. Hyperfine resolved Fourier transform microwave and millimeter-wave spectroscopy of the iodomethyl radical, CH2I (X2B1).
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