1. Cyanate as an Active Precursor of Ethyl Carbamate Formation in Sugar Cane Spirit.
- Author
-
Galinaro CA, Ohe TH, da Silva AC, da Silva SC, and Franco DW
- Subjects
- Cyanates metabolism, Ethanol chemistry, Hydrogen-Ion Concentration, Kinetics, Thermodynamics, Urethane metabolism, Alcoholic Beverages, Cyanates chemistry, Saccharum chemistry, Urethane chemistry
- Abstract
The thermodynamic and kinetic aspects of ethyl carbamate (EC) formation through the reaction between cyanate and ethanol were investigated. The rate constant values for cyanate ion decay and EC formation are (8.0 ± 0.4) × 10(-5) and (8.9 ± 0.4) × 10(-5) s(-1), respectively, at 25 °C in 48% aqueous ethanolic solution at pH 4.5. Under the investigated experimental conditions, the rate constants are independent of the ethanol and cyanate concentrations but increase as the temperature increases (ΔH1(⧧) = 19.4 ± 1 kcal/mol, ΔS1(⧧) = −12.1 ± 1 cal/K, and ΔG1(⧧) = 23.0 ± 1 kcal/mol) and decrease as the solution pH increases. According to molecular modeling (DFT) that was performed to analyze the reaction mechanism, the isocyanic acid (HNCO) is the active EC precursor. The calculated ΔG1(⧧), ΔH1(⧧), and ΔS1(⧧) values are in very good agreement with the experimental ones.
- Published
- 2015
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