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Start Over Author "Matsubara, Mamoru" Publisher american chemical society
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1. Interaction of calmodulin-binding domain peptides of nitric oxide synthase with membrane phospholipids: regulation by protein phosphorylation and Ca2+-calmodulin

Author

Matsubara, Mamoru, Titani, Koiti, and Taniguchi, Hisaaki

Subjects
Enzymes -- Research, Calmodulin -- Research, Proteins -- Research, Phosphorylation -- Research, Biological sciences, Chemistry
Abstract

A 20-amino acid peptide corresponding to the putative calmodulin-binding domain of human endothelial nitric oxide synthase (eNOS) was synthesized. The interaction of the peptide with calmodulin and with various membrane phospholipids was then examined. The peptide formed a stoichiometric complex with calmodulin. Upon addition of various acidic phospholipids, the peptide showed a drastic conformational change from random coil to alpha-helix. Findings showed that the same domain of eNOS binds both calmodulin and membrane phospholipids.

Published
1996

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