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Your search keyword '"Maglennon, Gareth A"' showing total 6 results
Start Over Author "Maglennon, Gareth A" Publisher american chemical society
6 results on '"Maglennon, Gareth A"'

1. Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging.

Author

Strittmatter, Nicole, Richards, Frances M., Race, Alan M., Ling, Stephanie, Sutton, Daniel, Nilsson, Anna, Wallez, Yann, Barnes, Jennifer, Maglennon, Gareth, Gopinathan, Aarthi, Brais, Rebecca, Wong, Edmond, Serra, Maria Paola, Atkinson, James, Smith, Aaron, Wilson, Joanne, Hamm, Gregory, Johnson, Timothy I., Dunlop, Charles R., and Kaistha, Brajesh P.

Published
2022
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6. Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging.

Author

Strittmatter, Nicole, Kanvatirth, Panchali, Inglese, Paolo, Race, Alan M., Nilsson, Anna, Dannhorn, Andreas, Kudo, Hiromi, Goldin, Robert D., Ling, Stephanie, Wong, Edmond, Seeliger, Frank, Serra, Maria Paola, Hoffmann, Scott, Maglennon, Gareth, Hamm, Gregory, Atkinson, James, Jones, Stewart, Bunch, Josephine, Andrén, Per E., and Takats, Zoltan

Abstract

A more complete and holistic view on host-microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histopathology with mass spectrometry imaging (MSI) and same section imaging mass cytometry (IMC) to study the effects of Salmonella Typhimurium infection in the liver of a mouse model using the S. Typhimurium strains SL3261 and SL1344. This approach enables correlation of tissue morphology and specific cell phenotypes with molecular images of tissue metabolism. IMC revealed a marked increase in immune cell markers and localization in immune aggregates in infected tissues. A correlative computational method (network analysis) was deployed to find metabolic features associated with infection and revealed metabolic clusters of acetyl carnitines, as well as phosphatidylcholine and phosphatidylethanolamine plasmalogen species, which could be associated with pro-inflammatory immune cell types. By developing an IMC marker for the detection of Salmonella LPS, we were further able to identify and characterize those cell types which contained S. Typhimurium. [ABSTRACT FROM AUTHOR]

Published
2021
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