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Your search keyword '"Luan, Zhi-Lin"' showing total 3 results
Start Over Author "Luan, Zhi-Lin" Publisher american chemical society
3 results on '"Luan, Zhi-Lin"'

3. Alismanin A, a Triterpenoid with a C 34 Skeleton from Alisma orientale as a Natural Agonist of Human Pregnane X Receptor.

Author

Wang C, Huo XK, Luan ZL, Cao F, Tian XG, Zhao XY, Sun CP, Feng L, Ning J, Zhang BJ, and Ma XC

Subjects
Humans, Molecular Structure, Pregnane X Receptor, Triterpenes, Alisma, Receptors, Steroid agonists
Abstract

Alismanin A (1), a novel aromatic triterpenoid with a C 34 skeleton, was isolated from Alisma orientale together with a rearranged nor-triterpenoid (2) and a 13,17-seco triterpenoid (3). Their structures were determined by a combination of HRESIMS, 2D NMR spectra, electronic circular dichroism (ECD), theoretical calculations, and X-ray diffraction analysis. Compounds 1 and 2 displayed significant activation effects on pregnane X receptor (PXR) at 10 nM. A plausible biosynthetic pathway for 1-3 is also discussed.

Published
2017
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