Search

Your search keyword '"Larionova NV"' showing total 1 results
Start Over Author "Larionova NV" Publisher american chemical society

Refine your results

1 results on '"Larionova NV"'

1. A cyclopentane conformational restraint for a peptide nucleic acid: design, asymmetric synthesis, and improved binding affinity to DNA and RNA.

Author

Myers MC, Witschi MA, Larionova NV, Franck JM, Haynes RD, Hara T, Grajkowski A, and Appella DH

Subjects
Alkylation, Drug Design, Stereoisomerism, Cyclopentanes chemical synthesis, Cyclopentanes metabolism, DNA metabolism, Peptide Nucleic Acids chemical synthesis, Peptide Nucleic Acids metabolism, RNA metabolism
Abstract

[structure: see text] A strategy to restrict the highly flexible backbone conformation of a peptide nucleic acid (PNA) by incorporation of a cyclopentane ring is proposed. An asymmetric synthesis of cyclopentane-modified PNA is reported, and its binding properties were determined. The cyclopentane ring leads to a significant improvement in the binding properties of the resulting PNA to DNA and RNA.

Published
2003
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results