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Start Over Author "Lanying Hu" Publisher american chemical society
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1. Giardia telomeric sequence d[(TAGGG).sub.4] forms two intramolecular G-quadruplexes in [K.sup.+] solution: effect of loop length and sequence on the folding topology

Author

Lanying Hu, Kah Wai Lim, Bouaziz, Serge, and Anh Tuan Phan

Subjects
Giardia -- Genetic aspects, Giardia -- Physiological aspects, Giardia lamblia -- Genetic aspects, Giardia lamblia -- Physiological aspects, Nuclear magnetic resonance spectroscopy -- Usage, Telomeres -- Structure, Telomeres -- Chemical properties, Chemistry
Abstract

The effect of loop length and sequence on the folding topology of G-quadruplexes is explored by examining the structure of the four-repeat Giardia telomeric sequence d[TAGGG[(TAGGG).sub.4]]. The recurrence of many structural elements in the structures have shown a ecut and pasteE principle for designing and predicting G-quadruplex topologies, for which different elements are extracted from one G-quadruplex and inserted into another.

Published
2009

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