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Your search keyword '"Lahdenpohja, Salla"' showing total 2 results
Start Over Author "Lahdenpohja, Salla" Publisher american chemical society
2 results on '"Lahdenpohja, Salla"'

2. Ruthenium-Mediated 18 F-Fluorination and Preclinical Evaluation of a New CB 1 Receptor Imaging Agent [ 18 F]FPATPP.

Author

Lahdenpohja S, Rajala NA, Helin JS, Haaparanta-Solin M, Solin O, López-Picón FR, and Kirjavainen AK

Subjects
Animals, Halogenation, Mice, Positron-Emission Tomography, Radiopharmaceuticals, Fluorine Radioisotopes, Ruthenium
Abstract

Cannabinoid receptor 1 (CB1R) controls various physiological and pathological conditions, including memory, motivation, and inflammation, and is thus an interesting target for positron emission tomography (PET). Herein, we report a ruthenium-mediated radiolabeling synthesis and preclinical evaluation of a new CB1R specific radiotracer, [ 18 F]FPATPP. [ 18 F]FPATPP was produced with 16.7 ± 5.7% decay-corrected radiochemical yield and >95 GBq/μmol molar activity. The tracer showed high stability, low defluorination, and high specific binding to CB1Rs in mouse brain.

Published
2020
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