Search

Your search keyword '"Kalansuriya, Pabasara"' showing total 2 results
Start Over Author "Kalansuriya, Pabasara" Publisher american chemical society
2 results on '"Kalansuriya, Pabasara"'

2. Roseopurpurins: Chemical Diversity Enhanced by Convergent Biosynthesis and Forward and Reverse Michael Additions.

Author

Shang Z, Khalil Z, Li L, Salim AA, Quezada M, Kalansuriya P, and Capon RJ

Subjects
Cell Line, Tumor, Cell Survival drug effects, Dose-Response Relationship, Drug, Humans, Molecular Structure, Penicillium chemistry, Polyketides chemistry, Polyketides metabolism, Prodrugs chemistry, Prodrugs metabolism, Structure-Activity Relationship, Penicillium metabolism, Polyketides pharmacology, Prodrugs pharmacology
Abstract

Cultures of the estuarine fungus Penicillium roseopurpureum (CMB-MF038) yielded a diverse array of polyketides, many of which were related via a highly convergent biosynthetic pathway. In addition to revising and assigning structures, and documenting chemical and biological properties, pro-drug cytotoxic properties were attributed to roseopurpurins H (10) and I (11) on the basis of in situ reverse Michael addition to a cytotoxic Michael acceptor (12).

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results