1. Harmonic nanocrystals for biolabeling: a survey of optical properties and biocompatibility.
- Author
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Staedler D, Magouroux T, Hadji R, Joulaud C, Extermann J, Schwung S, Passemard S, Kasparian C, Clarke G, Gerrmann M, Le Dantec R, Mugnier Y, Rytz D, Ciepielewski D, Galez C, Gerber-Lemaire S, Juillerat-Jeanneret L, Bonacina L, and Wolf JP
- Subjects
- Barium Compounds chemistry, Barium Compounds toxicity, Cell Line, Tumor, Colloids, Hemolysis drug effects, Humans, Hydrogen-Ion Concentration, Molecular Imaging, Niobium chemistry, Niobium toxicity, Oxides chemistry, Oxides toxicity, Phosphates chemistry, Phosphates toxicity, Photons, Polyethylene Glycols chemistry, Potassium chemistry, Potassium toxicity, Staining and Labeling, Titanium chemistry, Titanium toxicity, Water chemistry, Zinc Oxide chemistry, Zinc Oxide toxicity, Materials Testing, Nanoparticles chemistry, Nanoparticles toxicity, Optical Phenomena
- Abstract
Nonlinear optical nanocrystals have been recently introduced as a promising alternative to fluorescent probes for multiphoton microscopy. We present for the first time a complete survey of the properties of five nanomaterials (KNbO(3), LiNbO(3), BaTiO(3), KTP, and ZnO), describing their preparation and stabilization and providing quantitative estimations of their nonlinear optical response. In the light of their prospective use as biological and clinical markers, we assess their biocompatibility on human healthy and cancerous cell lines. Finally, we demonstrate the great potential for cell imaging of these inherently nonlinear probes in terms of optical contrast, wavelength flexibility, and signal photostability., (© 2012 American Chemical Society)
- Published
- 2012
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