1. Drug Mimetic Organogelators for the Control of Concomitant Crystallization of Barbital and Thalidomide
- Author
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Iván Torres-Moya, Matthew T. Mulvee, Jonathan W. Steed, Basanta Saikia, and Bipul Sarma
- Subjects
Drug ,010405 organic chemistry ,media_common.quotation_subject ,General Chemistry ,Pharmacology ,Barbital ,010402 general chemistry ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,law.invention ,Thalidomide ,chemistry.chemical_compound ,chemistry ,law ,Polymorphism (computer science) ,Concomitant ,Functional group ,medicine ,General Materials Science ,Crystallization ,Imide ,medicine.drug ,media_common - Abstract
A strategic approach to control the polymorphism of two related drugs by introducing a drug-mimetic imide functional group into the molecular weight organogelator structure is presented. This was achieved with novel aminoglutethimide-derived bis(urea) organogelators designed to form gels that act as targeted crystallization media for (±)-thalidomide and barbital. The organogelators prevent concomitant crystallization, a serious issue for drug formulation and development. This work demonstrates the potential to control concomitant crystallization with rationally designed supramolecular gelators.
- Published
- 2020