1. Rubesanolides A and B: diterpenoids from Isodon rubescens.
- Author
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Zou J, Pan L, Li Q, Zhao J, Pu J, Yao P, Gong N, Lu Y, Kondratyuk TP, Pezzuto JM, Fong HH, Zhang H, and Sun H
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Crystallography, X-Ray, Diterpenes chemistry, Diterpenes pharmacology, Drug Screening Assays, Antitumor, HeLa Cells, Humans, K562 Cells, Lactones chemistry, Molecular Conformation, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Leaves chemistry, Plants, Medicinal chemistry, Antineoplastic Agents, Phytogenic isolation & purification, Diterpenes isolation & purification, Isodon chemistry
- Abstract
From the medicinal plant Isodon rubescens, we isolated two novel diterpenes, rubesanolides A (1) and B (2). The compounds contain a unique β-lactone subgroup. This is the first discovery for a natural diterpene having rings A, B, and C in chair, boat, and twist-chair conformations, respectively. The structures were elucidated by analysis of spectroscopic data, and the absolute configuration of 1 was determined by X-ray diffraction.
- Published
- 2011
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