1. High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems
- Author
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Marcela Meneses, Gustavo R. Borges, Marcelo S. Zabaloy, Elton Franceschi, Cláudio Dariva, and Sandro R. P. da Rocha
- Subjects
Work (thermodynamics) ,Poly ethylene glycol ,Polyethylene glycol ,General Chemical Engineering ,02 engineering and technology ,INGENIERÍAS Y TECNOLOGÍAS ,chemistry.chemical_compound ,Tetrafluoroethane ,020401 chemical engineering ,Phase (matter) ,PEG ratio ,Organic chemistry ,0204 chemical engineering ,Chemistry ,General Chemistry ,021001 nanoscience & nanotechnology ,Ingeniería Química ,purl.org/becyt/ford/2.4 [https] ,High pressure ,Chemical engineering ,purl.org/becyt/ford/2 [https] ,Drug delivery ,Otras Ingeniería Química ,0210 nano-technology ,Ethylene glycol ,Phase behavior - Abstract
The development of polymeric systems for drug deliveryhas received attention with the aim of producing new systems as an alternative to conventional drug therapy. The design of new systems for this purpose in a compressed medium requires a knowledge of the phase behavior for the polymeric matrix in the high-pressure fluids. This work reports the phase equilibrium experimental data of binary systems involving poly(ethylene glycol) (PEG) with molecular weights of 1000and 2000 g·mol−1 and 1,1,1,2-tetrafluoroethane (HFA-134a). The experimental data were obtained in a high-pressure variable-volume viewing cell based on the static synthetic method at temperatures from 287.4 to 334.2 K, pressures of up to 29.81 MPa, and a PEG concentration in the range of 1 to 7 wt %. Liquid−liquid equilibrium,liquid−liquid−vapor equilibrium, and, in some cases, solid−liquid equilibrium were observed under the experimental conditions of pressure, temperature, and compositions investigated. The experimental results show that temperature and pressure have significant influences on the solubility of PEG in HFA-134a. The solid-phase formation for the system PEG + HFA-134a, in the range of values investigated for temperature, pressure, and compositions, is influenced by the molecular weight of the polymer. Fil: Oliveira Meneses, Marcela. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil Fil: Dariva, Claudio. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil Fil: Rodrigues Borges, Gustavo. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil Fil: da Rocha, Sandro R. P.. Virginia Commonwealth University; Estados Unidos Fil: Zabaloy, Marcelo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina Fil: Franceschi, Elton. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
- Published
- 2017
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