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Your search keyword '"Days, Emily"' showing total 2 results
Start Over "Days, Emily" Publisher american chemical society
2 results on '"Days, Emily"'

1. Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core

Author

Nance, Kellie D., Days, Emily L., Weaver, C. David, Coldren, Anastasia, Farmer, Tiffany D., Cho, Hyekyung P., Niswender, Colleen M., Blobaum, Anna L., Niswender, Kevin D., and Lindsley, Craig W.

Subjects
*GLUCAGON-like peptide-1 receptor, *URACIL, *DRUG bioavailability, *EXENDINS, *BLOOD sugar
Abstract

A duplexed, functional multiaddition high throughput screen and subsequent optimization effort identified the first orally bioavailable and CNS penetrant glucagon-like peptide-1 receptor (GLP-1R) noncompetitive antagonist. Antagonist 5d not only blocked exendin-4-stimulated insulin release in islets but also lowered insulin levels while increasing blood glucose in vivo. [ABSTRACT FROM AUTHOR]

Published
2017
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2. DihydrothiazolopyridoneDerivatives as a Novel Familyof Positive Allosteric Modulators of the Metabotropic Glutamate 5(mGlu5) Receptor.

Author

Bartolomé-Nebreda, José Manuel, Conde-Ceide, Susana, Delgado, Francisca, Iturrino, Laura, Pastor, Joaquín, Pena, Miguel Ángel, Trabanco, Andrés A., Tresadern, Gary, Wassvik, Carola M., Stauffer, Shaun R., Jadhav, Satyawan, Gogi, Kiran, Vinson, Paige N., Noetzel, Meredith J., Days, Emily, Weaver, C. David, Lindsley, Craig W., Niswender, Colleen M., Jones, Carrie K., and Conn, P. Jeffrey

Published
2013
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